Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities

Journal of Ayurveda and Integrative Medicine

Volumn 1, Issue 1, 2010, Pages 40-44

  Guruprasad, K P ^a   Mascarenhas, Roshan ^a   Gopinath, P M ^a   Satyamoorthy, K ^a  

^a MANIPAL UNIVERSITY   (India)

Author keywords

Aging; Brahma rasayana; chromosomal aberrations; genotoxicity; sperm abnormalities

Indexed keywords

ACORUS CALAMUS EXTRACT; AEGLE BRUHAT EXTRACT; AQUILARIA AGALLOCHA EXTRACT; ATROPA BELLADONA EXTRACT; AYURVEDIC DRUG; BOEHRAVIA DIFFUSA EXTRACT; BRAHMA RASAYANA; CARDAMOM EXTRACT; CENTELLA ASIATICA EXTRACT; CINNAMOMUM ZEYLANICUM EXTRACT; CLERODENDRON PREMNOSES EXTRACT; CONVOLVULUS PLURICAULIS EXTRACT; CURCUMA LONGA EXTRACT; CYPERUS ROTUNDUS EXTRACT; CYPERUS SCARIOSUS EXTRACT; DESMODIUM GANGETICUM EXTRACT; EMBELIA RIBES EXTRACT; EMBLICA OFFICINALIS EXTRACT; GLYCYRRHIZA GLABRA EXTRACT; GMELINA ARBOREA EXTRACT; HERBACEOUS AGENT; OROXYLUM INDICUM EXTRACT; PIPER LONGUM EXTRACT; PTEROSPERMUM SUAVEOLENS EXTRACT; SANTALUM ALBUM EXTRACT; SOLANUM XANTHOCARPUM EXTRACT; TERMINALIA CHEBULA EXTRACT; TRIBULUS TERRESTRIS EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; URARIA PICTA EXTRACT;

ACORUS CALAMUS; AEGLE BRUHAT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUILARIA AGALLOCHA; ARTICLE; ATROPA BELLADONA; BOEHRAVIA DIFFUSA; CARDAMOM; CENTELLA ASIATICA; CHROMOSOME ABERRATION; CINNAMOMUM ZEYLANICUM; CLERODENDRON PREMNOSES; CONTROLLED STUDY; CONVOLVULUS PLURICAULIS; CURCUMA LONGA; CYPERUS ROTUNDUS; CYPERUS SCARIOSUS; DESMODIUM GANGETICUM; DOSE RESPONSE; DRUG ISOLATION; EMBELIA RIBES; EMBLICA OFFICINALIS; GENOTOXICITY; GLYCYRRHIZA GLABRA; GMELINA ARBOREA; IN VIVO STUDY; MALE; MEDICINAL PLANT; MITOSIS INDEX; MOUSE; NONHUMAN; OROXYLUM INDICUM; PIPER LONGUM; PRIORITY JOURNAL; PTEROSPERMUM SUAVEOLENS; SANTALUM ALBUM; SEMEN ABNORMALITY; SIDA CORDIFOLIA; SOLANUM XANTHOCARPUM; TERMINALIA CHEBULA; TRIBULUS TERRESTRIS; URARIA PICTA;

EID: 79952905282     PISSN: 09759476     EISSN: 09762809     Source Type: Journal    
DOI: 10.4103/0975-9476.59826     Document Type: Article

References (26)

1. Patwardhan B, Warude D, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: a comparative overview. Evid Based Complement Alternat Med 2005;2:465-73. (Pubitemid 41752482)
2. Govindarajan R, Vijayakumar M, Pushpangadan P. Antioxidant approach to disease management and the role of rasayana herbs of Ayurveda. J Ethnopharmacol 2005;99:165-78. (Pubitemid 40724391)
3. Lele RD. 'Ayurveda and Modern Medicine' 2001; Bharathiya Vidya Bhavan, Mumbai-400 007, India.
4. Joshi H, Parle M. Brahmi Rasayana improves learning and memory in mice. Oxford Journals, Evidence based complementary and alternative. Medicine 2006;3:79-85. (Pubitemid 43999655)
5. Mohandas Rao KG, Muddanna Rao S, Gurumadhva Rao S. Centella asiatica (L) Leaf extract treatment during the growth Spurt period enhances hippocampal CA3 neuronal dendritic arborization in rats. Evid Based Complement Alternat Med 2006;3:349-57.
6. Dalsenter PR, Cavalcanti AM, Andrade AJ, Arajo SL, Marques MC. Reproductive evaluation of aqueous crude extract of Achillea millefolium L. (Asteraceae) in Wistar rats. Reprod Toxicol 2004;18:819-23. (Pubitemid 38987969)
7. Shukla MP. The concept of rasayana therapy in Indian medicine and a comprehensive approach to its evaluation. Indian J Hist Med 1971;16:42-6.
8. Allan JJ, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A. Reproductive and Fertility Effects of an Extract of Andrographis paniculata in Male Wistar Rats. Int J Toxicol 2009;28:308-17.
9. Baliga MS, Jagetia GC, Venkatesh P, Reddy R, Ulloor JN. Radioprotective effect of abana, a polyherbal drug following total body irradiation. Br J Radiol 2004;77:1027-35. (Pubitemid 40057800)
10. Gaddipati JP, Rajeshkumar NV, Thangapazham RL, Sharma A, Warren J, Mog SR, et al. Protective effect of polyherbal preparation, BR against tumor growth and lung metastasis in rat prostate model system. J Exp Ther Oncol 2004;4:203-12. (Pubitemid 39557171)
11. Thangapazham RL, Sharma A, Gaddipati JP, Singh AK, Maheshwari RK. Inhibition of tumor angiogenesis by BR. J Exp Ther Oncol 2006;6:13-21.
12. Ramnath V, Rekha PS, Sujatha KS. Amelioration of heat stress induced disturbances of antioxidant defence system in chicken by BR. Evid Based Complement Alternat Med 2008;5:77-84. (Pubitemid 351301951)
13. Rekha PS, Kuttan G, Kuttan R. Antioxidant activity of BR, Indian J Exp Biol 2001;39:447-52.
14. Kumar VP, Kuttan R, Kuttan G. Effect of 'rasayanas' a herbal drug preparation on cell-mediated immune responses in tumour bearing mice. Indian J Exp Biol 1999;37:23-6. (Pubitemid 29106510)
15. Kumar VP, Kuttan R, Kuttan G. Effect of 'rasayanas' a herbal drug preparation on immune responses and its significance in cancer treatment. Indian J Exp Biol 1999;37:27-31. (Pubitemid 29106511)
16. Evans EP, Breckon G, Ford CE. Air drying method for meiotic preparations from mammalian testes. Cytogenetics 1964;3:289-94.
17. Searle AG, Beechey CV. Sperm count, egg fertilization and dominant lethality after X-irradiation of mice. Mutat Res 1974;11:63-72.
18. Wyrobek AJ, Bruce WR. The induction of sperm-shape abnormalities in mice and humans. In: chemical Mutagens: principles and Methods for Their Detection, Eds A. Hollaender and F. J. de Serres. Vol. 5 Plenum Press, New York. 1978.255-85.
19. Singh RH, Narsimhamurthy K, Singh G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Biogerontology 2008;9:369-74.
20. Sharma N, Trikha P, Athar M, Raisuddin S. Inhibitory effect of Emblica officinalis on the in vivo clastogenecity of benzo[a]pyrene and cyclophosphamide in mice. Hum Exp Toxicol 2000;19:377-84.
21. Perreault SD, Cancel AM. Significance of incorporating measures of sperm production and function into rat toxicology studies. Reproduction 2001;121:207-16. (Pubitemid 32175543)
22. Rekha PS, Kuttan G, Kuttan R. Effect of herbal preparation, BR in amelioration of radiation induced damage. Indian J Exp Biol 2000;38:999-1002. (Pubitemid 32143088)
23. Rekha PS, Kuttan G, Kuttan R. Effect of BR on antioxidant systems and cytokine reveals in mice during cyclophosphamide administration. J Exp Clin Cancer Res 2001;20:219-23. (Pubitemid 32641064)
24. Rekha PS, Kuttan G, Kuttan R. Effect of BR on antioxidant systems after radiation. Indian J Exp Biol 2001;39:1173-5.
25. Kumar PV, Kuttan R, Kuttan G. Chemoprotective action of rasayanas against cyclophosphamide toxicity. Tumori 1994;80:306-8. (Pubitemid 24339856)
26. Joseph CD, Praveenkumar V, Kuttan G, Kuttan R. Myeloproliferative effect of a nontoxic indigenous preparation rasayana in cancer patients receiving chemotherapy and radiation therapy, a pilot study. J Exp Clin Cancer Res 1999;18:325-9.