Pre-clinical toxicity assessment of tumor-targeted interleukin-12 low-intensity electrogenetherapy

Cancer Gene Therapy

Volumn 18, Issue 4, 2011, Pages 265-274

  Reed, S D ^a   Li, S ^b  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

electroporation; IL 12; toxicity; tumor targeting

Indexed keywords

ALANINE AMINOTRANSFERASE; DNA; GAMMA INTERFERON; INTERLEUKIN 12; SODIUM CHLORIDE; TUMOR MARKER; TUMOR TARGETED INTERLEUKIN 12; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPSY; BLOOD CELL COUNT; CALCIFICATION; CONTROLLED STUDY; DRUG DOSE ESCALATION; ELECTROPORATION; FEMALE; GENE THERAPY; HISTOPATHOLOGY; INFECTION; LEUKOCYTE COUNT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TARGET ORGAN;

ANIMALS; ELECTROPORATION; FEMALE; GENE FUSION; GENE THERAPY; INTERLEUKIN-12; MALE; MICE; MICE, INBRED C3H; NEOPLASMS; ORGAN SIZE; PEPTIDES; TOXICITY TESTS;

MUS;

EID: 79952900802     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2010.77     Document Type: Article

References (29)

1. Yoshida A, Koide Y, Uchijima M, Yoshida TO. IFN-gamma induces IL-12 mRNA expression by a murine macrophage cell line, J774. Biochem Biophys Res Commun 1994; 198: 857-861.
2. Tannenbaum CS, Tubbs R, Armstrong D, Finke JH, Bukowski RM, Hamilton TA. The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor. J Immunol 1998; 161: 927-932. (Pubitemid 28323558)
3. Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994; 84: 4008-4027. (Pubitemid 24371902)
4. Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, Murphy M et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 1993; 178: 1223-1230. (Pubitemid 23277355)
5. Nastala CL, Edington HD, McKinney TG, Tahara H, Nalesnik MA, Brunda MJ et al. Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol 1994; 153: 1697-1706. (Pubitemid 24251114)
6. Cohen J. IL-12 deaths: explanation and a puzzle. Science 1995; 270: 908.
7. Leonard JP, Sherman ML, Fisher GL, Buchanan LJ, Larsen G, Atkins MB et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interfer-on-gamma production. Blood 1997; 90: 2541-2548. (Pubitemid 27413462)
8. Carson WE, Yu H, Dierksheide J, Pfeffer K, Bouchard P, Clark R et al. A fatal cytokine-induced systemic inflammatory response reveals a critical role for NK cells. J Immunol 1999; 162: 4943-4951. (Pubitemid 29314901)
9. Li S, Zhang X, Xia X. Regression of tumor growth and induction of long-term antitumor memory by interleukin 12 electro-gene therapy. J Natl Cancer Inst 2002; 94: 762-768. (Pubitemid 34567961)
10. Daud AI, DeConti RC, Andrews S, Urbas P, Riker AI, Sondak VK et al. Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J Clin Oncol 2008; 26: 5896-5903.
11. Heller L, Merkler K, Westover J, Cruz Y, Coppola D, Benson K et al. Evaluation of toxicity following electrically mediated interleukin-12 gene delivery in a B16 mouse melanoma model. Clin Cancer Res 2006; 12: 3177-3183. (Pubitemid 43837367)
12. Muramatsu T, Nakamura A, Park HM. In vivo electropora-tion: a powerful and convenient means of nonviral gene transfer to tissues of living animals (Review). Int J Mol Med 1998; 1: 55-62.
13. Reed SD, Li S. Electroporation advances in large animals. Curr Gene Ther; e-pub ahead of print 1 August 2009.
14. Li S. Delivery of DNA into tumors. Methods Mol Biol 2008; 423: 311-318.
15. Trollet C, Scherman D, Bigey P. Delivery of DNA into muscle for treating systemic diseases: advantages and challenges. Methods Mol Biol 2008; 423: 199-214.
16. Trollet C, Bloquel C, Scherman D, Bigey P. Electrotransfer into skeletal muscle for protein expression. Curr Gene Ther 2006; 6: 561-578. (Pubitemid 44524460)
17. Fedorov VV, Nikolski VP, Efimov IR. Effect of electro-poration on cardiac electrophysiology. Methods Mol Biol 2008; 423: 433-448.
18. Serafini P, De Santo C, Marigo I, Cingarlini S, Dolcetti L, Gallina G et al. Derangement of immune responses by myeloid suppressor cells. Cancer Immunol Immunother 2004; 53: 64-72. (Pubitemid 38161211)
19. Kiessling R, Wasserman K, Horiguchi S, Kono K, Sjoberg J, Pisa P et al. Tumor-induced immune dysfunction. Cancer Immunol Immunother 1999; 48: 353-362. (Pubitemid 29461387)
20. Carrio R, Lopez DM. Impaired thymopoiesis occurring during the thymic involution of tumor-bearing mice is associated with a down-regulation of the antiapoptotic proteins Bcl-XL and A1. Int J Mol Med 2009; 23: 89-98.
21. Car BD, Eng VM, Lipman JM, Anderson TD. The toxicology of interleukin-12: a review. Toxicol Pathol 1999; 27: 58-63. (Pubitemid 29075746)
22. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-2088. (Pubitemid 29001265)
23. Eaton GJ, Custer RP, Johnson FN, Stabenow KT. Dystrophic cardiac calcinosis in mice: genetic, hormonal, and dietary influences. Am J Pathol 1978; 90: 173-186. (Pubitemid 8257484)
24. Korff S, Riechert N, Schoensiegel F, Weichenhan D, Autschbach F, Katus HA et al. Calcification of myocardial necrosis is common in mice. Virchows Arch 2006; 448: 630-638. (Pubitemid 44490561)
25. Aherrahrou Z, Doehring LC, Ehlers EM, Liptau H, Depping R, Linsel-Nitschke P et al. An alternative splice variant in Abcc6, the gene causing dystrophic calcification, leads to protein deficiency in C3H/He mice. J Biol Chem 2008; 283: 7608-7615.
26. Gang DL, Barrett LV, Wilson EJ, Rubin RH, Medearis DN. Myopericarditis and enhanced dystrophic cardiac calcification in murine cytomegalovirus infection. Am J Pathol 1986; 124: 207-215.
27. Price P, Eddy KS, Papadimitriou JM, Faulkner DL, Shellam GR. Genetic determination of cytomegalovirus-induced and age-related cardiopathy in inbred mice. Characterization of infiltrating cells. Am J Pathol 1991; 138: 59-67.
28. Lostroh A, Li CH. Deposition induced by hydrocortisone of calcium in the heart tissue of female C3H mice. Nature 1955; 176: 504.
29. Sparks LL, Rosenau W, Macalpin RN, Daane TA, Li CH. Production of dystrophic calcification of cardiac muscle in mice by hydrocortisone. Nature 1955; 176: 503-504.