Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients

Neuroscience Letters

Volumn 493, Issue 3, 2011, Pages 131-135

  Španiel, Filip ^a,b   Horáček, Jiří ^a,b   Tintěra, Jaroslav ^c   Ibrahim, Ibrahim ^c   Novák, Tomáš ^a,b   Čermák, Jan ^a,b   Klirova Monika M ^a,b   Höschl, Cyril ^a,b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

FOXP2; Genetics; Grey matter; Schizophrenia; VBM; Voxel based morphometry

Indexed keywords

TRANSCRIPTION FACTOR FOXP2;

ADULT; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GRAY MATTER; HALLUCINATION; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADENINE NUCLEOTIDES; ADOLESCENT; ADULT; CEREBRAL CORTEX; CROSS-SECTIONAL STUDIES; CYTOSINE NUCLEOTIDES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENETIC VARIATION; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; YOUNG ADULT;

EID: 79952899733     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.02.024     Document Type: Article

References (26)

1. Belton E., Salmond C.H., Watkins K.E., Vargha-Khadem F., Gadian D.G. Bilateral brain abnormalities associated with dominantly inherited verbal and orofacial dyspraxia. Hum. Brain Mapp. 2003, 18:194-200.
2. Ekstrom P.O. Scanning for DNA variants by denaturant capillary electrophoresis. Methods Mol. Biol. 2008, 439:19-34.
3. Fisher S.E., Scharff C. FOXP2 as a molecular window into speech and language. Trends Genet. 2009, 25:166-177.
4. Fornito A., Yucel M., Patti J., Wood S.J., Pantelis C. Mapping grey matter reductions in schizophrenia: an anatomical likelihood estimation analysis of voxel-based morphometry studies. Schizophr. Res. 2009, 108:104-113.
5. Glahn D.C., Laird A.R., Ellison-Wright I., Thelen S.M., Robinson J.L., Lancaster J.L., Bullmore E., Fox P.T. Meta-analysis of grey matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis. Biol. Psychiatry 2008, 64:774-781.
6. Gong X.H., Jia M.X., Ruan Y., Shuang M., Liu J., Wu S.P., Guo Y.Q., Yang J.Z., Ling Y.S., Yang X.L., Zhang D. Association between the FOXP2 gene and autistic disorder in Chinese population. Am. J. Med. Genet. B 2004, 127B:113-116.
7. Honea R., Crow T.J., Passingham D., Mackay C.E. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am. J. Psychiatry 2005, 162:2233-2245.
8. Johnson M.B., Kawasawa Y.I., Mason C.E., Krsnik Z., Coppola G., Bogdanovic D., Geschwind D.H., Mane S.M., State M.W., Sestan N. Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron 2009, 62:494-509.
9. Keshavan M.S., Prasad K.M., Pearlson G. Are brain structural abnormalities useful as endophenotypes in schizophrenia?. Int. Rev. Psychiatry 2007, 19:397-406.
10. Lai C.S., Fisher S.E., Hurst J.A., Vargha-Khadem F., Monaco A.P. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 2001, 413:519-523.
11. Li X., Branch C.A., DeLisi L.E. Language pathway abnormalities in schizophrenia: a review of fMRI and other imaging studies. Curr. Opin. Psychiatry 2009, 22:131-139.
12. Louro R., Smirnova A.S., Verjovski-Almeida S. Long intronic noncoding RNA transcription: expression noise or expression choice?. Genomics 2009, 93:291-298.
13. MacDermot K.D., Bonora E., Sykes N., Coupe A.M., Lai C.S., Vernes S.C., Vargha-Khadem F., McKenzie F., Smith R.L., Monaco A.P., Fisher S.E. Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. Am. J. Hum. Genet. 2005, 76:1074-1080.
14. Minarik M., Benesova L., Fantova L., Horacek J., Heracek J., Loukola A. Parallel optimisation and genotyping of multiple single-nucleotide polymorphism markers by sample pooling approach using cycling-gradient CE with multiple injections. Electrophoresis 2006, 27:3856-3863.
15. Newbury D.F., Bonora E., Lamb J.A., Fisher S.E., Lai C.S.L., Baird G., Jannoun L., Slonims V., Stott C.M., Merricks M.J., Bolton P.F., Bailey A.J., Monaco A.P. FOXP2 is not a major susceptibility gene for autism or specific language impairment. Am. J. Hum. Genet. 2002, 70:1318-1327.
16. Prasad K.M., Keshavan M.S. Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct " extended endophenotypes" ?. Schizophr. Bull. 2008, 34:774-790.
17. Sanjuan J., Tolosa A., Gonzalez J.C., Aguilar E.J., Perez-Tur J., Najera C., Molto M.D., de F.R. Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations. Psychiatr. Genet. 2006, 16:67-72.
18. Spiteri E., Konopka G., Coppola G., Bomar J., Oldham M., Ou J., Vernes S.C., Fisher S.E., Ren B., Geschwind D.H. Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am. J. Hum. Genet. 2007, 81:1144-1157.
19. Stephane M., Barton S., Boutros N.N. Auditory verbal hallucinations and dysfunction of the neural substrates of speech. Schizophr. Res. 2001, 50:61-78.
20. Tandon R., Keshavan M.S., Nasrallah H.A. Schizophrenia, " just the facts" what we know in 2008. 2. Epidemiology and etiology. Schizophr. Res. 2008, 102:1-18.
21. Thompson P.M., Cannon T.D., Narr K.L., van E.T., Poutanen V.P., Huttunen M., Lonnqvist J., Standertskjold-Nordenstam C.G., Kaprio J., Khaledy M., Dail R., Zoumalan C.I., Toga A.W. Genetic influences on brain structure. Nat. Neurosci. 2001, 4:1253-1258.
22. Tolosa A., Sanjuan J., Dagnall A.M., Molto M.D., Herrero N., de Frutos R. FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies. BMC Med. Genet. 2010, 11.
23. van Haren N.E., Bakker S.C., Kahn R.S. Genes and structural brain imaging in schizophrenia. Curr. Opin. Psychiatry 2008, 21:161-167.
24. Vernes S.C., Spiteri E., Nicod J., Groszer M., Taylor J.M., Davies K.E., Geschwind D.H., Fisher S.E. High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders. Am. J. Hum. Genet. 2007, 81:1232-1250.
25. Watkins K.E., Vargha-Khadem F., Ashburner J., Passingham R.E., Connelly A., Friston K.J., Frackowiak R.S., Mishkin M., Gadian D.G. MRI analysis of an inherited speech and language disorder: structural brain abnormalities. Brain 2002, 125:465-478.
26. Zeesman S., Nowaczyk M.J., Teshima I., Roberts W., Cardy J.O., Brian J., Senman L., Feuk L., Osborne L.R., Scherer S.W. Speech and language impairment and oromotor dyspraxia due to deletion of 7q31 that involves FOXP2. Am. J. Med. Genet. A 2006, 140:509-514.