Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease

Neurobiology of Aging

Volumn 32, Issue 3, 2011, Pages 541-543

  Laws, S M ^a,b   Eckart, K ^b   Friedrich, P ^b   Kurz, A ^b   Forstl H ^b   Riemenschneider, M ^b  

^a EDITH COWAN UNIVERSITY   (Australia)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

ADAM10; Alzheimer's disease; APP; BACE1; Beta amyloid; Genetics

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID BETA PROTEIN; BETA SECRETASE 1;

ADAM10 ENDOPEPTIDASE GENE; ALZHEIMER DISEASE; ARTICLE; BETA SECRETASE 1 GENE; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAM PROTEINS; AGED; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 79952897620     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2009.02.023     Document Type: Article

References (12)

1. Bertram L., McQueen M.B., Mullin K., Blacker D., Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 2007, 39(1):17-23.
2. Blacker D., Bertram L., Saunders A.J., Moscarillo T.J., Albert M.S., Wiener H., Perry R.T., Collins J.S., Harrell L.E., Go R.C., Mahoney A., Beaty T., Fallin M.D., Avramopoulos D., Chase G.A., Folstein M.F., McInnis M.G., Bassett S.S., Doheny K.J., Pugh E.W., Tanzi R.E. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum. Mol. Genet. 2003, 12(1):23-32.
3. Edbauer D., Winkler E., Regula J., Pesold B., Steiner H., Haass C. Reconstitution of gamma-secretase activity. Nat. Cell Biol. 2003, 5:486-488.
4. Hardy J.A., Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992, 256(5054):184-185.
5. Kojro E., Fahrenholz F. The non-amyloidogenic pathway: structure and function of alpha-secretases. Subcell. Biochem. 2005, 38:105-127.
6. Lammich S., Kojro E., Postina R., Gilbert S., Pfeiffer R., Jasionowski M., Haass C., Fahrenholz F. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. U.S.A. 1999, 96(7):3922-3927.
7. Martins R.N., Clarnette R., Fisher C., Broe G.A., Brooks W.S., Montgomery P., Gandy S.E. ApoE genotypes in Australia: roles in early and late onset Alzheimer's disease and Down's syndrome. Neuroreport 1995, 6(11):1513-1516.
8. Prinzen C., Muller U., Endres K., Fahrenholz F., Postina R. Genomic structure and functional characterization of the human ADAM10 promoter. FASEB J. 2005, 19(11):1522-1524.
9. Saunders A.M., Strittmatter W.J., Schmechel D., George-Hyslop P.H., Pericak-Vance M.A., Joo S.H., Rosi B.L., Gusella J.F., Crapper-MacLachlan D.R., Alberts M.J. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993, 43(8):1467-1472.
10. Scott W.K., Hauser E.R., Schmechel D.E., Welsh-Bohmer K.A., Small G.W., Roses A.D., Saunders A.M., Gilbert J.R., Vance J.M., Haines J.L., Pericak-Vance M.A. Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. Am. J. Hum. Genet. 2003, 73(5):1041-1051.
11. Todd S., McKnight A.J., Liu W.W., Carson R., Heggarty S., McGuinness B., Irvine G.B., Craig D., Passmore A.P., Johnston J.A. BACE1 polymorphisms do not influence platelet membrane beta-secretase activity or genetic susceptibility for Alzheimer's disease in the northern Irish population. Neuromol. Med. 2008, 10(4):368-376.
12. Vassar R., Bennett B., Babu-Khan S., Kahn S., Mendiaz E., Denis P., Teplow D., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M., Biere A., Curran E., Burgess T., Louis J., Collins F., Treanor J., Rogers G., Citron M. b-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999, 286:735-741.