Intravitreal ranibizumab for symptomatic drusenoid pigment epithelial detachment without choroidal neovascularization in age-related macular degeneration

Clinical Ophthalmology

Volumn 5, Issue 1, 2011, Pages 161-165

  Gallego Pinazo, Roberto ^a,b   Suelves Cogollos, Ana Marina ^a   Francés Muñoz, Ester ^a   Millán, J María ^a,b   Arevalo, J Fernando ^c   Mullor, J Luis ^a   Díaz Llopis, Manuel ^a,b,d  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c Clinica Oftalmologica Centro Caracas   (Venezuela)

^d UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Age related macular degeneration; Choroidal neovascularization; Drusenoid pigment epithelial detachment; Ranibizumab; Soft drusen

Indexed keywords

RANIBIZUMAB;

ADULT; AGED; ARTICLE; CENTRAL MACULAR THICKNESS; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; HUMAN; MALE; OPTICAL COHERENCE TOMOGRAPHY; OUTCOME ASSESSMENT; PILOT STUDY; PROSPECTIVE STUDY; RETINA DETACHMENT; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL FLUID; SUBRETINAL NEOVASCULARIZATION; VISUAL ACUITY; VISUAL SYSTEM PARAMETERS;

EID: 79952839173     PISSN: 11775467     EISSN: 11775483     Source Type: Journal    
DOI: 10.2147/OPTH.S15832     Document Type: Article

References (19)

1. Casswell AG, Kohen D, Bird AC. Retinal pigment epithelium detachments in the elderly: Classification and outcome. Br J Ophthalmol. 1985;69:397-403.
2. Hartnett ME, Weiter JJ, Garsd A, Jalkh AE. Classification of pigment epithelial detachments associated with drusen. Graefes Arch Clin Exp Ophthalmol. 1992;230:11-19.
3. Sarks SH. Ageing and degeneration in the macular region: A clinicopathological study. Br J Ophthalmol. 1976;60:324-341.
4. Bressler NM, Silva JC, Bressler SB, Fine SL, Green WR. Clinicopathologic correlation of drusen and retinal pigment epithelial abnormalities in agerelated macular degeneration. Retina. 1994;14:130-142.
5. Spraul CW, Grossniklaus HE. Characteristics of drusen and Bruch's membrane in post-mortem eyes with age-related macular degeneration. Arch Ophthalmol. 1997;115:267-273.
6. Pauleikhoff D, Löffert D, Spital G, et al. Pigment epithelial detachments in the elderly: Clinical differentiation, natural course and pathogenic implications. Graefes Arch Clin Exp Ophthalmol. 2002;240:533-538.
7. Roquet W, Roudot-Thoraval F, Coscas G, Soubrane G. Clinical features of drusenoid pigment epithelial detachment in age related macular degeneration. Br J Ophthalmol. 2004;88:638-642.
8. Cukras C, Agrón E, Klein ML, et al. Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: Age-Related Eye Disease Study Report No. 28. Ophthalmology. 2010;17:489-499.
9. Age-Related Eye Disease Study Research Group. A randomized, placebocontrolled, clinical trial of high-dose supplementation with vitamins C and E, beta caroten, and zinc for age-related macular degeneration and vision loss: AREDS Report No. 8. Arch Ophthalmol. 2001;119:1417-1436.
10. Figueroa MS, Regueras A, Bertrand J. Laser photocoagulation to treat macular soft drusen in age-related macular degeneration. Retina. 1994; 14:391-396.
11. Frennesson C, Nilsson SE. Prophylactic laser treatment in early agerelated maculopathy reduced the incidence of exudative complications. Br J Ophthalmol. 1998;82:1169-1174.
12. Macular Photocoagulation Study Group. Argon laser photocoagulation for neovascular maculopathy: Five-year results from randomized clinical trials. Arch Ophthalmol. 1991;109:1109-1114.
13. Olk RJ, Friberg TR, Stickney KL, et al. Therapeutic benefits of infrared (810-nm) diode laser macular grid photocoagulation in prophylactic treatment of nonexudative age-related macular degeneration: Two-year results of a randomized pilot study. Ophthalmology. 1999;106: 2082-2090.
14. Lee NY, Kim KS. Photodynamic therapy treatment for eyes with drusenoid pigment epithelium detachment. Korean J Ophthalmol. 2008; 22:194-196.
15. Querques G, Bux AV, Delle Noci N. Foveal geographic atrophy following intravitreal pegaptanib sodium (Macugen) for drusenoid pigment epithelium detachment. Eur J Ophthalmol. 2009;19:890-893.
16. Krishnan R, Lochhead J. Regression of soft drusen and drusenoid pigment epithelial detachment following intravitreal anti-vascular endothelial growth factor therapy. Can J Ophthalmol. 2010;45:83-84.
17. Díaz-Llopis M, Cervera E, Amselem L, Udaondo P, Salom D, Montero J. Amsler grid versus near acuity and reading vision chart: Early selfdiagnosis in neovascular age-related macular degeneration. Arch Soc Esp Oftalmol. 2008;83:578-579. [Spanish].
18. Sarks JP, Sarks SH, Killingsworth MC. Evolution of soft drusen in age-related macular degeneration. Eye. 1994;8:269-283.
19. Abdelsalam A, Del Piore L, Zarbin MA. Drusen in age-related macular degeneration, natural course, and laser photocoagulation-induced regresión. Surv Ophthalmol. 1999;44:1-29.