Detection of novel coupled mutations in the katG gene (His276Met, Gln295His and Ser315Thr) in a multidrug-resistant Mycobacterium tuberculosis strain from Chennai, India, and insight into the molecular mechanism of isoniazid resistance using structural bioinformatics approaches

International Journal of Antimicrobial Agents

Volumn 37, Issue 4, 2011, Pages 368-372

  Ramasubban, Gayathri ^a   Therese, Kulandai Lily ^a   Vetrivel, Umashankar ^a   Sivashanmugam, Muthukumaran ^a   Rajan, Parvathy ^b   Sridhar, R ^c   Madhavan, Hajib N ^a   Meenakshi, N ^d  

^a VISION RESEARCH FOUNDATION   (India)

^b AMRITA UNIVERSITY   (India)

^c STANLEY MEDICAL COLLEGE   (India)

^d Institute of Thoracic Medicine   (India)

Author keywords

Docking; Homology modelling; Isoniazid; katG; Molecular dynamics; Mycobacterium tuberculosis

Indexed keywords

ETHAMBUTOL; GLUTAMINE; HISTIDINE; ISONIAZID; KATG PROTEIN; METHIONINE; PYRAZINAMIDE; RIFAMPICIN; SERINE; STREPTOMYCIN; THREONINE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BIOINFORMATICS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME STRUCTURE; GENE MUTATION; GENE TARGETING; INDIA; KATG GENE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MULTIDRUG RESISTANCE; MUTATIONAL ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; WILD TYPE;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; CATALASE; COMPUTATIONAL BIOLOGY; DNA PRIMERS; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; INDIA; ISONIAZID; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; MYCOBACTERIUM TUBERCULOSIS; POLYMERASE CHAIN REACTION;

EID: 79952815955     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.11.023     Document Type: Article

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