메뉴 건너뛰기




Volumn 12, Issue 2, 2011, Pages 131-137

Overall survival of patients with advanced pancreatic cancer improved with an increase in second-line chemotherapy after gemcitabine-based therapy

Author keywords

Gemcitabine; Pancreatic neoplasms; Regression analysis; Salvage therapy

Indexed keywords

CAPECITABINE; CISPLATIN; EPIRUBICIN; ERLOTINIB; FLUOROURACIL; GEMCITABINE; IRINOTECAN; MARIMASTAT; OXALIPLATIN;

EID: 79952793227     PISSN: 15908577     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (8)

References (42)
  • 1
    • 40949151618 scopus 로고    scopus 로고
    • Devita VT Jr, Hellman S, Rosenberg SA. Cancer: Principles & Practice of Oncology, 7th ed USA Philadelphia: Lippincott Williams & Wilkins
    • Yeo CJ. Cancer of the Pancreas. In: Devita VT Jr, Hellman S, Rosenberg SA. Cancer: Principles & Practice of Oncology, 7th ed USA Philadelphia: Lippincott Williams & Wilkins, 2005:945.
    • (2005) Cancer of the Pancreas , pp. 945
    • Yeo, C.J.1
  • 2
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • PMID 9196156
    • Burris HA 3rd, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997; 15:2403-2413. [PMID 9196156]
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3    Green, M.R.4    Rothenberg, M.L.5    Modiano, M.R.6
  • 3
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • PMID 12149301
    • Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson AB 3rd. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 2002; 20:3270-3275. [PMID 12149301]
    • (2002) J Clin Oncol , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson III, A.B.6
  • 4
    • 0037083621 scopus 로고    scopus 로고
    • Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: A prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale
    • PMID 11920457
    • Colucci G, Giuliani F, Gebbia V, Biglietto M, Rabitti P, Uomo G, et al. Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale. Cancer 2002; 94:902-910. [PMID 11920457]
    • (2002) Cancer , vol.94 , pp. 902-910
    • Colucci, G.1    Giuliani, F.2    Gebbia, V.3    Biglietto, M.4    Rabitti, P.5    Uomo, G.6
  • 5
    • 73949135518 scopus 로고    scopus 로고
    • Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • PMID 19858379
    • Cunningham D, Chau I, Stocken DD, Valle JW, Smith D, Steward W, et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol 2009; 27: 5513-5518. [PMID 19858379]
    • (2009) J Clin Oncol , vol.27 , pp. 5513-5518
    • Cunningham, D.1    Chau, I.2    Stocken, D.D.3    Valle, J.W.4    Smith, D.5    Steward, W.6
  • 6
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
    • PMID 15908661
    • Louvet C, Labianca R, Hammel P, Lledo G, Zampino MG, André T, et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol 2005; 23:3509-3516. [PMID 15908661]
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3    Lledo, G.4    Zampino, M.G.5    André, T.6
  • 7
    • 77955914277 scopus 로고    scopus 로고
    • Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-Directed Intergroup Trial S0205
    • PMID 20606093
    • Philip PA, Benedetti J, Corless CL, Wong R, O'Reilly EM, Flynn PJ, et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-Directed Intergroup Trial S0205. J Clin Oncol 2010; 28:3605-3610. [PMID 20606093]
    • (2010) J Clin Oncol , vol.28 , pp. 3605-3610
    • Philip, P.A.1    Benedetti, J.2    Corless, C.L.3    Wong, R.4    O'Reilly, E.M.5    Flynn, P.J.6
  • 8
    • 77955887676 scopus 로고    scopus 로고
    • Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
    • PMID 20606091
    • Kindler HL, Niedzwiecki D, Hollis D, Sutherland S, Schrag D, Hurwitz H, et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 2010; 28:3617-3622. [PMID 20606091]
    • (2010) J Clin Oncol , vol.28 , pp. 3617-3622
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3    Sutherland, S.4    Schrag, D.5    Hurwitz, H.6
  • 9
    • 45449090215 scopus 로고    scopus 로고
    • Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study
    • PMID 18514303
    • Spano JP, Chodkiewicz C, Maurel J, Wong R, Wasan H, Barone C, et al. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study. Lancet 2008; 371:2101-2108. [PMID 18514303]
    • (2008) Lancet , vol.371 , pp. 2101-2108
    • Spano, J.P.1    Chodkiewicz, C.2    Maurel, J.3    Wong, R.4    Wasan, H.5    Barone, C.6
  • 10
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • PMID 17452677
    • Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007; 25:1960-1966. [PMID 17452677]
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6
  • 11
    • 68949114505 scopus 로고    scopus 로고
    • Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: A trial of the Eastern Cooperative Oncology Group
    • PMID 19581537
    • Poplin E, Feng Y, Berlin J, Rothenberg ML, Hochster H, Mitchell E, et al. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2009; 27:3778-3785. [PMID 19581537]
    • (2009) J Clin Oncol , vol.27 , pp. 3778-3785
    • Poplin, E.1    Feng, Y.2    Berlin, J.3    Rothenberg, M.L.4    Hochster, H.5    Mitchell, E.6
  • 12
    • 77954771890 scopus 로고    scopus 로고
    • 5FU/leucovorin (LV), irinotecan (I), and oxaliplatin (O)) versus gemcitabine (G) as first-line treatment for metastatic pancreatic adenocarcinoma (MPA): Preplanned interim analysis results of the Prodige 4/Accord 11 trial
    • Abstract
    • Conroy T, Desseigne F, Ychou M, Ducreux M, Bouche O, Guimbaud R, et al. Randomized phase III trial comparing FOLFIRINOX (F: 5FU/leucovorin (LV), irinotecan (I), and oxaliplatin (O)) versus gemcitabine (G) as first-line treatment for metastatic pancreatic adenocarcinoma (MPA): Preplanned interim analysis results of the PRODIGE 4/ACCORD 11 trial. J Clin Oncol 2010; 28(15 Suppl.):Abstract 4010.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL , pp. 4010
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3    Ducreux, M.4    Bouche, O.5    Guimbaud, R.6
  • 13
    • 0037099604 scopus 로고    scopus 로고
    • Multicenter randomized phase III trial comparing protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin in inoperable pancreatic cancer
    • PMID 12118027
    • Maisey N, Chau I, Cunningham D, Norman A, Seymour M, Hickish T, et al. Multicenter randomized phase III trial comparing protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin in inoperable pancreatic cancer. J Clin Oncol 2002; 20:3130-3136. [PMID 12118027]
    • (2002) J Clin Oncol , vol.20 , pp. 3130-3136
    • Maisey, N.1    Chau, I.2    Cunningham, D.3    Norman, A.4    Seymour, M.5    Hickish, T.6
  • 14
    • 0036668658 scopus 로고    scopus 로고
    • A randomised trial comparing 5-FU with 5-FU plus cisplatin in advanced pancreatic carcinoma
    • PMID 12181240
    • Ducreux M, Rougier P, Pignon JP, Douillard JY, Seitz JF, Bugat R, et al. A randomised trial comparing 5-FU with 5-FU plus cisplatin in advanced pancreatic carcinoma. Ann Oncol 2002; 13:1185-1191. [PMID 12181240]
    • (2002) Ann Oncol , vol.13 , pp. 1185-1191
    • Ducreux, M.1    Rougier, P.2    Pignon, J.P.3    Douillard, J.Y.4    Seitz, J.F.5    Bugat, R.6
  • 16
    • 63849329062 scopus 로고    scopus 로고
    • Second-line therapy in refractory pancreatic cancer. results of a phase II study
    • PMID 19295247
    • Pelzer U, Stieler J, Roll L, Hilbig A, Dörken B, Riess H, Oettle H. Second-line therapy in refractory pancreatic cancer. results of a phase II study. Onkologie 2009; 32:99-102. [PMID 19295247]
    • (2009) Onkologie , vol.32 , pp. 99-102
    • Pelzer, U.1    Stieler, J.2    Roll, L.3    Hilbig, A.4    Dörken, B.5    Riess, H.6    Oettle, H.7
  • 17
    • 55749103379 scopus 로고    scopus 로고
    • Phase 2 trial of oxaliplatin plus capecitabine (XELOX) as second-line therapy for patients with advanced pancreatic cancer
    • PMID 18756532
    • Xiong HQ, Varadhachary GR, Blais JC, Hess KR, Abbruzzese JL, Wolff RA. Phase 2 trial of oxaliplatin plus capecitabine (XELOX) as second-line therapy for patients with advanced pancreatic cancer. Cancer 2008; 113:2046-2052. [PMID 18756532]
    • (2008) Cancer , vol.113 , pp. 2046-2052
    • Xiong, H.Q.1    Varadhachary, G.R.2    Blais, J.C.3    Hess, K.R.4    Abbruzzese, J.L.5    Wolff, R.A.6
  • 19
    • 27144530079 scopus 로고    scopus 로고
    • A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer
    • PMID 16087696
    • Oettle H, Richards D, Ramanathan RK, van Laethem JL, Peeters M, Fuchs M, et al. A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann Oncol 2005; 16:1639-1645. [PMID 16087696]
    • (2005) Ann Oncol , vol.16 , pp. 1639-1645
    • Oettle, H.1    Richards, D.2    Ramanathan, R.K.3    van Laethem, J.L.4    Peeters, M.5    Fuchs, M.6
  • 20
    • 33749071359 scopus 로고    scopus 로고
    • Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer
    • PMID 16983112
    • Abou-Alfa GK, Letourneau R, Harker G, Modiano M, Hurwitz H, Tchekmedyian NS, et al. Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer. J Clin Oncol 2006; 24:4441-4447. [PMID 16983112]
    • (2006) J Clin Oncol , vol.24 , pp. 4441-4447
    • Abou-Alfa, G.K.1    Letourneau, R.2    Harker, G.3    Modiano, M.4    Hurwitz, H.5    Tchekmedyian, N.S.6
  • 21
    • 0036637150 scopus 로고    scopus 로고
    • Gemcitabine or gemcitabine plus cisplatin for in 42 patients with locally advanced or metastatic pancreatic cancer
    • PMID 12408777
    • Wang XY, Ni Q, Jin M, Li ZS, Wu YX, Zhao YP, Feng F. Gemcitabine or gemcitabine plus cisplatin for in 42 patients with locally advanced or metastatic pancreatic cancer. Chin J Oncol 2002; 24:404-407. [PMID 12408777]
    • (2002) Chin J Oncol , vol.24 , pp. 404-407
    • Wang, X.Y.1    Ni, Q.2    Jin, M.3    Li, Z.S.4    Wu, Y.X.5    Zhao, Y.P.6    Feng, F.7
  • 22
    • 77951523140 scopus 로고    scopus 로고
    • Observation of therapeutic efficacy of a biweekly regimen of Gemzar plus oxaliplatin for 30 cases with advanced pancreatic cancer
    • Yan ZC, Hong J, Xie GR. Observation of therapeutic efficacy of a biweekly regimen of Gemzar plus oxaliplatin for 30 cases with advanced pancreatic cancer. Chin J Clin Oncol 2007; 6:322-325.
    • (2007) Chin J Clin Oncol , vol.6 , pp. 322-325
    • Yan, Z.C.1    Hong, J.2    Xie, G.R.3
  • 23
    • 12244296736 scopus 로고    scopus 로고
    • Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: A randomized phase II trial
    • PMID 12488300
    • Scheithauer W, Schüll B, Ulrich-Pur H, Schmid K, Raderer M, Haider K, et al. Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: a randomized phase II trial. Ann Oncol 2003; 14:97-104. [PMID 12488300]
    • (2003) Ann Oncol , vol.14 , pp. 97-104
    • Scheithauer, W.1    Schüll, B.2    Ulrich-Pur, H.3    Schmid, K.4    Raderer, M.5    Haider, K.6
  • 24
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • PMID 15084616
    • Van Cutsem E, van de Velde H, Karasek P, Oettle H, Vervenne WL, Szawlowski A, et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 2004; 22:1430-1438. [PMID 15084616]
    • (2004) J Clin Oncol , vol.22 , pp. 1430-1438
    • van Cutsem, E.1    Van de, V.H.2    Karasek, P.3    Oettle, H.4    Vervenne, W.L.5    Szawlowski, A.6
  • 25
    • 0036205980 scopus 로고    scopus 로고
    • NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial
    • PMID 11914932
    • Gansauge F, Ramadani M, Pressmar J, Gansauge S, Muehling B, Stecker K, et al. NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial. Langenbecks Arch Surg 2002; 386:570-574. [PMID 11914932]
    • (2002) Langenbecks Arch Surg , vol.386 , pp. 570-574
    • Gansauge, F.1    Ramadani, M.2    Pressmar, J.3    Gansauge, S.4    Muehling, B.5    Stecker, K.6
  • 26
    • 77950498286 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: The GIP-1 study
    • PMID 20194854
    • Colucci G, Labianca R, Di Costanzo F, Gebbia V, Cartenì G, Massidda B, et al. Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study. J Clin Oncol 2010; 28:1645-1651. [PMID 20194854]
    • (2010) J Clin Oncol , vol.28 , pp. 1645-1651
    • Colucci, G.1    Labianca, R.2    di Costanzo, F.3    Gebbia, V.4    Cartenì, G.5    Massidda, B.6
  • 27
    • 33748445708 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer
    • PMID 16921047
    • Heinemann V, Quietzsch D, Gieseler F, Gonnermann M, Schönekäs H, Rost A, et al. Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J Clin Oncol 2006; 24:3946-3952. [PMID 16921047]
    • (2006) J Clin Oncol , vol.24 , pp. 3946-3952
    • Heinemann, V.1    Quietzsch, D.2    Gieseler, F.3    Gonnermann, M.4    Schönekäs, H.5    Rost, A.6
  • 28
    • 4644327989 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
    • PMID 15365074
    • Rocha Lima CM, Green MR, Rotche R, Miller WH Jr, Jeffrey GM, Cisar LA, et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol 2004; 22:3776-3783. [PMID 15365074]
    • (2004) J Clin Oncol , vol.22 , pp. 3776-3783
    • Rocha, L.C.M.1    Green, M.R.2    Rotche, R.3    Miller Jr., W.H.4    Jeffrey, G.M.5    Cisar, L.A.6
  • 29
    • 33748297529 scopus 로고    scopus 로고
    • A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer
    • PMID 16909140
    • Stathopoulos GP, Syrigos K, Aravantinos G, Polyzos A, Papakotoulas P, Fountzilas G, et al. A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer. Br J Cancer 2006; 95:587-592. [PMID 16909140]
    • (2006) Br J Cancer , vol.95 , pp. 587-592
    • Stathopoulos, G.P.1    Syrigos, K.2    Aravantinos, G.3    Polyzos, A.4    Papakotoulas, P.5    Fountzilas, G.6
  • 30
    • 34250180939 scopus 로고    scopus 로고
    • Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: A randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group
    • PMID 17538165
    • Herrmann R, Bodoky G, Ruhstaller T, Glimelius B, Bajetta E, Schüller J, et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol 2007; 25:2212-2217. [PMID 17538165]
    • (2007) J Clin Oncol , vol.25 , pp. 2212-2217
    • Herrmann, R.1    Bodoky, G.2    Ruhstaller, T.3    Glimelius, B.4    Bajetta, E.5    Schüller, J.6
  • 31
    • 19944409357 scopus 로고    scopus 로고
    • Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: A randomised controlled multicentre phase III trial
    • PMID 15925814
    • Reni M, Cordio S, Milandri C, Passoni P, Bonetto E, Oliani C, et al. Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: a randomised controlled multicentre phase III trial. Lancet Oncol 2005; 6:369-376. [PMID 15925814]
    • (2005) Lancet Oncol , vol.6 , pp. 369-376
    • Reni, M.1    Cordio, S.2    Milandri, C.3    Passoni, P.4    Bonetto, E.5    Oliani, C.6
  • 32
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • PMID 12107836
    • Bramhall SR, Schulz J, Nemunaitis J, Brown PD, Baillet M, Buckels JA. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 2002; 87:161-167. [PMID 12107836]
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 33
    • 23644437797 scopus 로고    scopus 로고
    • Gemcitabine with or without continuous infusion 5-FU in advanced pancreatic cancer: A randomised phase II trial of the Italian oncology group for clinical research (GOIRC)
    • PMID 15986036
    • Di Costanzo F, Carlini P, Doni L, Massidda B, Mattioli R, Iop A, et al. Gemcitabine with or without continuous infusion 5-FU in advanced pancreatic cancer: a randomised phase II trial of the Italian oncology group for clinical research (GOIRC). Br J Cancer 2005; 93:185-189. [PMID 15986036]
    • (2005) Br J Cancer , vol.93 , pp. 185-189
    • di Costanzo, F.1    Carlini, P.2    Doni, L.3    Massidda, B.4    Mattioli, R.5    Iop, A.6
  • 34
    • 77952554897 scopus 로고    scopus 로고
    • Gemcitabine-based cytotoxic doublets chemotherapy for advanced pancreatic cancer: Updated subgroup meta-analyses of overall survival
    • PMID 20147334
    • Xie DR, Yang Q, Chen DL, Jiang ZM, Bi ZF, Ma W, Zhang YD. Gemcitabine-based cytotoxic doublets chemotherapy for advanced pancreatic cancer: updated subgroup meta-analyses of overall survival. Jpn J Clin Oncol 2010; 40:432-441. [PMID 20147334]
    • (2010) Jpn J Clin Oncol , vol.40 , pp. 432-441
    • Xie, D.R.1    Yang, Q.2    Chen, D.L.3    Jiang, Z.M.4    Bi, Z.F.5    Ma, W.6    Zhang, Y.D.7
  • 35
    • 79952809976 scopus 로고    scopus 로고
    • Comorbidity and overall survival (OS) in patients with advanced pancreatic cancer (APC): Results from NCIC CTG PA.3-A phase III trial of erlotinib plus gemcitabine (E+G) versus gemcitabine (G) alone
    • Abstract
    • Vickers MM, Powell ED, Asmis TR, Jonker DJ, O'Callaghan CJ, Tu D, et al. Comorbidity and overall survival (OS) in patients with advanced pancreatic cancer (APC): Results from NCIC CTG PA.3-A phase III trial of erlotinib plus gemcitabine (E+G) versus gemcitabine (G) alone. J Clin Oncol 2010; 28(15 Suppl.):Abstract 4079.
    • J Clin Oncol 2010 , vol.28 , Issue.15 SUPPL , pp. 4079
    • Vickers, M.M.1    Powell, E.D.2    Asmis, T.R.3    Jonker, D.J.4    O'Callaghan, C.J.5    Tu, D.6
  • 36
    • 77955290859 scopus 로고    scopus 로고
    • Impact of S-1 in patients with gemcitabine-refractory pancreatic cancer in Japan
    • PMID 20462979
    • Nakai Y, Isayama H, Sasaki T, Sasahira N, Kogure H, Hirano K, et al. Impact of S-1 in patients with gemcitabine-refractory pancreatic cancer in Japan. Jpn J Clin Oncol 2010; 40:774-780. [PMID 20462979]
    • (2010) Jpn J Clin Oncol , vol.40 , pp. 774-780
    • Nakai, Y.1    Isayama, H.2    Sasaki, T.3    Sasahira, N.4    Kogure, H.5    Hirano, K.6
  • 37
    • 85047686019 scopus 로고    scopus 로고
    • Oxaliplatin, 5-fluorouracil, and leucovorin as second-line treatment for advanced pancreatic cancer
    • PMID 19194124
    • Novarino A, Satolli MA, Chiappino I, Giacobino A, Bellone G, Rahimi F, et al. Oxaliplatin, 5-fluorouracil, and leucovorin as second-line treatment for advanced pancreatic cancer. Am J Clin Oncol 2009; 32:44-48. [PMID 19194124]
    • (2009) Am J Clin Oncol , vol.32 , pp. 44-48
    • Novarino, A.1    Satolli, M.A.2    Chiappino, I.3    Giacobino, A.4    Bellone, G.5    Rahimi, F.6
  • 38
    • 33344475959 scopus 로고    scopus 로고
    • Oxaliplatin/folinic acid/5-fluorouracil 24h (OFF) plus best supportive care versus best supportive care alone (BSC) in second-line therapy of gemcitabine-refractory advanced pancreatic cancer (CONKO 003)
    • Abstract
    • Oettle H, Pelzer U, Stieler J, Hilbig A, Roll L, Schwaner I, et al. Oxaliplatin/folinic acid/5-fluorouracil 24h (OFF) plus best supportive care versus best supportive care alone (BSC) in second-line therapy of gemcitabine-refractory advanced pancreatic cancer (CONKO 003). J Clin Oncol 2005; 23(16 Suppl.):Abstract 4031.
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL , pp. 4031
    • Oettle, H.1    Pelzer, U.2    Stieler, J.3    Hilbig, A.4    Roll, L.5    Schwaner, I.6
  • 39
    • 68149150786 scopus 로고    scopus 로고
    • Comparing two methods of meta-analysis in clinical research - individual patient data-based (IPD) and literature-based abstracted data (AD) methods: Analyzing five oncology issues involving more than 10,000 patients in randomized clinical trials (RCTs)
    • Abstract
    • Brias E, Gralla RJ, Raftopoulos H, Giannarelli D. Comparing two methods of meta-analysis in clinical research - individual patient data-based (IPD) and literature-based abstracted data (AD) methods: Analyzing five oncology issues involving more than 10,000 patients in randomized clinical trials (RCTs). J Clin Oncol 2007; 25(18 Suppl.):Abstract 6512.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL , pp. 6512
    • Brias, E.1    Gralla, R.J.2    Raftopoulos, H.3    Giannarelli, D.4
  • 40
    • 78650245775 scopus 로고    scopus 로고
    • Clinical and molecular determinants of survival in pancreatic cancer patients treated with second-line chemotherapy: Results of an Italian/Swiss multicenter survey
    • PMID 21036754
    • Mancuso A, Sacchetta S, Saletti PC, Tronconi C, Milesi L, Garassino M, et al. Clinical and molecular determinants of survival in pancreatic cancer patients treated with second-line chemotherapy: results of an Italian/Swiss multicenter survey. Anticancer Res 2010; 30:4289-4295. [PMID 21036754]
    • (2010) Anticancer Res , vol.30 , pp. 4289-4295
    • Mancuso, A.1    Sacchetta, S.2    Saletti, P.C.3    Tronconi, C.4    Milesi, L.5    Garassino, M.6
  • 41
    • 76749169766 scopus 로고    scopus 로고
    • The role of pemetrexed as maintenance treatment in advanced NSCLC: A Phase III randomized trial
    • PMID 20053140
    • Gridelli C, Di Maio M. The role of pemetrexed as maintenance treatment in advanced NSCLC: a Phase III randomized trial. Expert Opin Pharmacother 2010; 11:321-3224. [PMID 20053140]
    • (2010) Expert Opin Pharmacother , vol.11 , pp. 321-3224
    • Gridelli, C.1    Di, M.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.