'Big' science: Genome regulatory networks and novel molecular tools to improve health

Expert Review of Molecular Diagnostics

Volumn 11, Issue 2, 2011, Pages 123-126

  Roukos, Dimitrios H ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

Author keywords

big research projects; health; regulatory networks; structure function genome; translational medicine

Indexed keywords

BIOLOGICAL MARKER;

AGING; BIODIVERSITY; BIOTECHNOLOGY; CANCER GENETICS; CARDIOVASCULAR DISEASE; CHRONIC DISEASE; DIABETES MELLITUS; FATALITY; GENE EXPRESSION; GENE MUTATION; GENE REGULATORY NETWORK; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEALTH; HUMAN GENOME; HUMAN GENOME PROJECT; MEDICAL PRACTICE; MEDICAL RESEARCH; MOLECULAR BIOLOGY; NEOPLASM; REVIEW; SCIENTIST; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT FAILURE;

ANIMALS; BIOMEDICAL RESEARCH; DISEASE; GENE REGULATORY NETWORKS; GENOME; HUMANS; NEOPLASMS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 79952780387     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/erm.11.4     Document Type: Review

References (23)

1. The human genome at ten. Nature 464(7289), 649-650 (2010).
2. Roukos DH. Next-generation sequencing and epigenome technologies: Potential medical applications. Expert Rev. Med. Devices 7(6), 723-726(2010).
3. Manolio TA. Genomewide association studies and assessment of the risk of disease. N. Engl. J. Med. 363(2), 166-176 (2010).
4. Check Hayden E. Human genome at ten: Life is complicated. Nature 464(7289), 664-667 (2010).
5. Katsios C, Roukos DH. Individual genomes and personalized medicine: Life diversity and complexity. Pers. Med. 7(4), 347-350 (2010).
6. -1000 Genomes Project Consortium; Durbin RM, Abecasis GR, Altshuler DL et al. A map of human genome variation from population-scale sequencing. Nature 467(7319), 1061-1073 (2010).
7. ENCODE Project Consortium; Birney E, Stamatoyannopoulos JA, Dutta A et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447(7146), 799-816 (2007). (Pubitemid 46920138)
8. modENCODE Consortium; Roy S, Ernst J, Kharchenko PV et al. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science 330(6012), 1787-1797 (2010).
9. Gerstein MB, Lu ZJ, Van Nostrand EL et al. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 330(6012), 1775-1787 (2010).
10. International HapMap Consortium; Frazer KA, Ballinger DG, Cox DR et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449(7164), 851-861 (2007). (Pubitemid 47598626)
11. International HapMap 3 Consortium; Altshuler DM, Gibbs RA, Peltonen L et al. Integrating common and rare genetic variation in diverse human populations. Nature 467(7311), 52-58 (2010).
12. Baker M. Genomics: The search for association. Nature 467(7319), 1135-1138 (2010).
13. Human genome: Genomes by the thousand. Nature 467, 1026-1027 (2010)
14. Roukos DH. Trastuzumab and beyond: Sequencing cancer genomes and predicting molecular networks. Pharmacogenomics J. DOI: 10.1038/tpj.2010.81 (2010) (Epub ahead of print).
15. Roukos DH. Cancer genome explosion and systems biology: Impact on surgical oncology? Ann. Surg. Oncol. 18(1), 12-15 (2011).
16. International Cancer Genome Consortium; Hudson TJ, Anderson W, Artez A et al. International network of cancer genome projects. Nature 464, 993-998 (2010).
17. Alberts B. Model organisms and human health. Science 330(6012), 1724 (2010).
18. Blaxter M. Genetics. Revealing the dark matter of the genome. Science 330(6012), 1758-1759 (2010).
19. Beltrao P, Cagney G, Krogan N. Quantitative genetic interactions reveal biological modularity. Cell 141(5), 739-745 (2010).
20. Schadt EE. Molecular networks as sensors and drivers of common human diseases. Nature 461(7261), 218-223 (2010).
21. Garzon R, Marcucci G, Croce CM. Targeting microRNAs in cancer: Rationale, strategies and challenges. Nat. Rev. Drug Discov. 9(10), 775-789 (2010).
22. Kelly TK, De Carvalho DD, Jones PA. Epigenetic modifications as therapeutic targets. Nat. Biotechnol. 28(10), 1069-1078 (2010).
23. Perry AS, Watson RW, Lawler M, Hollywood D. The epigenome as a therapeutic target in prostate cancer. Nat. Rev. Urol. 7(12), 668-680 (2010).