Platelet-derived growth factor receptor alpha is associated with oxidative stress-induced retinal cell death

Current Eye Research

Volumn 36, Issue 4, 2011, Pages 336-340

  Kanamoto, Takashi ^a   Rimayanti, Ulfah ^a   Okumichi, H ^a   Kiuchi, Yoshiaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cell death; Oxidative stress; PDGF AA; PDGFR ; Retinal cells

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER 1; HYDROGEN PEROXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RETINA CELL; RETINA GANGLION CELL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL DEATH; CELL LINE; CELL SURVIVAL; EXCITATORY AMINO ACID TRANSPORTER 3; FEEDBACK, PHYSIOLOGICAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HYDROGEN PEROXIDE; MICE; MICE, INBRED ICR; OXIDATIVE STRESS; PLATELET-DERIVED GROWTH FACTOR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RETINA; RETINAL GANGLION CELLS; RNA, SMALL INTERFERING;

EID: 79952766065     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2011.556301     Document Type: Article

References (24)

1. Gabelt, BT, Kaufman PL. Changes in aqueous humor dynamics with age and glaucoma. Retin Eye Res. 2005;24:612-637. (Pubitemid 40943663)
2. Levin LA. Axonal loss and neuroprotection in optic neuropathies. Can J Ophthalmol. 2007;42:403-408 (Pubitemid 46932033)
3. Yucel YH, Zhang Q, Weinreb RN, et al. Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Retin Eye Res. 2003;22:465-481. (Pubitemid 36556145)
4. Weinreb RN. Glaucoma neuroprotection: What is it? Why is it needed? Can J Ophthalmol. 2007;42:396-398.
5. Tezel G. Oxidative stress in glaucomatous neurodegeneration: Mechanisms and consequences. Retin Eye Res. 2006;25:490-513. (Pubitemid 44389961)
6. Dringen R, Pfeiffer B, Hamprecht B. Synthesis of the antioxidant glutathione in neurons: Supply by astrocytes of CysGly as precursor for neuronal glutathione. J Neurosci. 1999;19:562-569. (Pubitemid 29036007)
7. Harada T, Harada C, Nakamura K, et al. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J Clin Invest. 2007;117:1763-1770. (Pubitemid 47036310)
8. Okumichi H, Kanamoto T, Souchelnytskyi N, et al. Proteomic analyses of retina of excitatory amino acid carrier 1 deficient mice. Proteome Sci. 2007;5:1-6.
9. Fredriksson L, Li H, Eriksson U. The PDGF family: Four gene products form five dimeric isoforms. Cytokine Growth Factor Rev. 2004;15:197-204. (Pubitemid 38781045)
10. Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes & Development. 2008;22:1276-1312. (Pubitemid 351717519)
11. Tallquist M, Kazlauskas A. PDGF signaling in cells and mice. Cytokine Growth Factor Rev. 2004;15:205-213. (Pubitemid 38781046)
12. Pringle NP, Mudhar HS, Collarini EJ, et al. PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha- receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. Development. 1992;115:535-551.
13. Betsholtz C. Insight into the physiological functions of PDGF through genetic studies in mice. Cytokine Growth Factor Rev. 2004;15:215-228. (Pubitemid 38781047)
14. Fruttiger M, Calver AR, Kruger WH, et al. PDGF mediates a neuron-astrocyte interaction in the developing retina. Neuron. 1996;17:1117-1131. (Pubitemid 27021098)
15. Andrews A, Balciunaite E, Leong FL, et al. Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 1999;40:2683-2689 (Pubitemid 29455500)
16. Biswas SK, Zhao Y, Nagalingam A, et al. PDGF-and insulin/ IGF-1-specific distinct nodes of class xA PI3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells. Invest Ophthalmol Vis Sci. 2008;49:3687-3698.
17. Peghini P, Janzen J, Stoffel W. Glutamate transporter EAAC-1-deficient mice develope dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J. 1997;16:3822-3832. (Pubitemid 27280998)
18. Krishnamoorthy RR, Agarwal P, Prasanna G, et al. Characterization of a transformed rat retinal ganglion cell line. Mol Brain Res. 2001;86:1-12. (Pubitemid 32124753)
19. Kanamoto T, Hellman U, Heldin C-H, et al. Functional proteomics of transforming growth factor-β1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFβ1-dependent regulation of DNA repair. EMBO J. 2002;21:1219-1230. (Pubitemid 34206195)
20. Okumichi H, Mizukami M, Kiuchi Y, et al. GABA(A) receptors are associated with retinal ganglion cell death induced by oxidative stress. Exp Eye Res. 2008;86:727-733.
21. Cox OT, Simpson DAC, Stitt AW, et al. Sources of PDGF expression in murine retina and the effect of short-term diabetes. Mol Vis. 2003;9:665-672. (Pubitemid 38097632)
22. Aoyama K, Suh SW, Hamby AM, et al. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci. 2006;9:119-126. (Pubitemid 43011917)
23. Fournier KM, Gonzalez MI, Robinson MB. Rapid trafficking of the neuronal glutamate transporter, EAAC1. J Biol Chem. 2004;279:34505-34513.
24. Fruttiger M, Calver AR, Richardson WD. Platelet-derived growth factor is constitutively secreted from neuronal cell bodies but not axons. Cur Biol. 2000;10:1283-1286.