GABAA receptors are associated with retinal ganglion cell death induced by oxidative stress

Experimental Eye Research

Volumn 86, Issue 5, 2008, Pages 727-733

  Okumichi, Hideaki ^a   Mizukami, Mina ^a   Kiuchi, Yoshiaki ^a   Kanamoto, Takashi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

bicuculline; GABAA receptor; oxidative stress; retinal ganglion cell

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; BICUCULLINE; HYDROGEN PEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BICUCULLINE; BLOTTING, WESTERN; CELL DEATH; CELL LINE; GABA AGONISTS; GABA ANTAGONISTS; HYDROGEN PEROXIDE; MICE; MICE, INBRED ICR; MUSCIMOL; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RECEPTORS, GABA-A; RETINAL GANGLION CELLS; SIGNAL TRANSDUCTION; TRANSFECTION; UP-REGULATION;

EID: 42749086060     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2008.01.019     Document Type: Article

References (34)

1. Barnett N.L., and Grozdanic S.D. Glutamate transporter localization does not correspond to the temporary functional recovery and late degeneration after acute ocular ischemia in rats. Exp. Eye Res. 79 (2004) 513-524
2. Bazan N.G., Birkle D.L., Tang W., and Reddy T.S. The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy. Adv. Neurol. 44 (1986) 879-902
3. + channels as targets of CNS drug development. Curr. Drug Targets CNS Neurol. Disord. 3 (2004) 161-167
4. Bormann J. The 'ABC' of GABA receptors. Trends Pharmacol. Sci. 21 (2000) 16-19
5. Bormann J., Hamill O.P., and Sakmann B. Mechanism of anion permeation through channels gated by glycine and γ-aminobutyric acid in mouse cultured spinal neurons. J. Physiol. 385 (1987) 243-286
6. Bowery N.G., and Smart T.G. GABA and glycine as neurotransmitters: a brief history. Br. J. Pharmacol. 147 (2006) S109-S119
7. Chen Q., Moulder K., Tenkova T., Hardy K., Olney J.W., and Romano C. Excitotoxic cell death dependent on inhibitory receptor activation. Exp. Neurol. 160 (1999) 215-225
8. Cory A.H., Owen T.C., Barltrop J.A., and Cory J.G. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun. 3 (1991) 207-212
9. Demuro A., Palma E., Eusebi F., and Miledi R. Inhibition of nicotinic acetylcholine receptors by bicuculline. Neuropharmacology 41 (2001) 854-861
10. Green A.R., Hainsworth A.H., and Jackson D.M. GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke. Neuropharmacology 39 (2000) 1483-1494
11. Harada T., Harada C., Nakamura K., Quah H.M.A., Okumura A., Namekata K., Saeki T., Aihara M., Yoshida H., Mitani A., and Takana K. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J. Clin. Invest. 117 (2007) 1763-1770
12. Honegger P., Pardo B., and Monnet-Tschudi F. Muscimol-induced death of GABAergic neurons in rat brain aggregating cell cultures. Dev. Brain Res. 105 (1998) 219-225
13. 3 subunits: comparisons in DBA/2J and C57BL/6J mice. Biochim. Biophys. Acta 1261 (1995) 134-142
14. Kanamoto T., Hellman U., Heldin C.H., and Souchelnytskyi S. Functional proteomics of transforming growth factor-β1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFβ1-dependent regulation of DNA repair. EMBO J. 21 (2002) 1219-1230
15. Kannan K., and Jain S.K. Oxidative stress and apoptosis. Pathophysiology 7 (2000) 153-163
16. Kiryu-Seo S., Gamo K., Tachibana T., Tanaka K., and Kiyama H. Unique anti-apoptotic activity of EAAC1 in injured motor neurons. EMBO J. 25 (2006) 3411-3421
17. Krishnamoorthy R.R., Agarwal P., Prasanna G., Vopat K., Lambert W., Sheedlo H.J., Pang I.H., Shade D., Wordingera R.J., Yorioc T., Clark A.F., and Agarwal N. Characterization of a transformed rat retinal ganglion cell line. Mol. Brain Res. 86 (2001) 1-12
18. Li Y., King M.A., and Meyer E.M. α7 nicotinic receptor-mediated protection against ethanol-induced oxidative stress and cytotoxicity in PC12 cells. Brain Res. 861 (2000) 165-167
19. A-mediated toxicity of hippocampal neurons in vitro. J. Neurochem. 74 (2000) 2445-2454
20. Maher P., and Hanneken A. The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line. Invest. Ophthalmol. Vis. Sci. 46 (2005) 749-757
21. Maruyama W., Hashizume Y., Matsubara K., and Naoi M. Identification of 3-nitro-l-tyrosine, a product of nitric oxide and superoxide, as an indicator of oxidative stress in the human brain. J. Chromatogr. B Biomed. Appl. 676 (1996) 153-158
22. Okumichi H., Kanamoto T., Souchelnytskyi N., Tanimoto S., Tanaka K., and Kiuchi Y. Proteomic analyses of retina of excitatory amino acid carrier 1 deficient mice. Proteome Sci. 5 (2007) 13
23. Peghini P., Janzen J., and Stoffel W. Glutamate transporter EAAC1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J. 16 (1997) 3822-3832
24. Rogawski M.A. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 (2006) 273-294
25. Rothstein J.D., Martin L., Levey A.I., Dykes-Hoberg M., Jin L., Wu D., Nash N., and Kuncl R.W. Localization of neuronal and glial glutamate transporters. Neuron 13 (1994) 713-725
26. A receptor subtype functions. Curr. Opin. Pharmacol. 6 (2006) 18-23
27. Sepkuty J.P., Cohen A.S., Eccles C., Rafiq A., Behar K., Ganel R., Coulter D.A., and Rothstein J.D. A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. J. Neurosci. 22 (2002) 6372-6379
28. Stoothoff W.H., and Johnson G.V.W. Hyperosmotic stress-induced apoptosis and Tau phosphorylation in human neuroblastoma cells. J. Neurosci. Res. 65 (2001) 573-582
29. Sun W., Seigel G.M., and Salvi R.J. Retinal precursor cells express functional ionotropic glutamate and GABA receptors. Neuroreport 13 (2002) 2421-2424
30. Wässle H., and Boycott B.B. Functional architecture of the mammalian retina. Physiol. Rev. 71 (1991) 447-480
31. Wiessner M., Fletcher E.L., Fischer F., and Rauen T. Localization and possible function of the glutamate transporter, EAAC1, in the rat retina. Cell Tissue Res. 310 (2002) 31-40
32. Wilkins M.E., Hosie A.M., and Smart T.G. Identification of a β subunit TM2 residue mediating proton modulation of GABA type A receptors. J. Neurosci. 22 (2002) 5328-5333
33. Yang X.L. Characterization of receptors for glutamate and GABA in retinal neurons. Prog. Neurobiol. 73 (2004) 127-150
34. A receptor β subunit heterogeneity: functional expression of cloned cDNAs. EMBO J. 8 (1989) 1665-1670