Increased levels of 4HNE-protein plasma adducts in Rett syndrome

Clinical Biochemistry

Volumn 44, Issue 5-6, 2011, Pages 368-371

  Pecorelli, Alessandra ^a   Ciccoli, Lucia ^a   Signorini, Cinzia ^a   Leoncini, Silvia ^a   Giardini, Anna ^a   D'Esposito, Maurizio ^b   Filosa, Stefania ^b   Hayek, Joussef ^c   De Felice, Claudio ^c   Valacchi, Giuseppe ^a,d  

^a UNIVERSITY OF SIENA   (Italy)

^b INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^c UNIVERSITY HOSPITAL OF SIENA   (Italy)

^d Kyung Hee University   (South Korea)

Author keywords

4 Hydroxynonenal; CDKL5; FOXG1; MeCP2; Oxidative stress; Rett syndrome

Indexed keywords

4 HYDROXYNONENAL; 4 HYDROXYNONENAL PLASMA PROTEIN ADDUCT; CYCLIN DEPENDENT KINASE 5; FORKHEAD BOX G1 PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; METHYL CPG BINDING PROTEIN 2; PLASMA PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENETIC VARIABILITY; HUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETT SYNDROME; SCHOOL CHILD; WESTERN BLOTTING;

ADOLESCENT; ADULT; ALDEHYDES; BLOTTING, WESTERN; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MUTATION; NERVE TISSUE PROTEINS; RETT SYNDROME; YOUNG ADULT;

EID: 79952765428     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2011.01.007     Document Type: Article

References (24)

1. Rett A. Uber ein eigartiges hirnatrophisches Syndrom bei Hyperammoniamie in Kindesalter. Wien Med Wochenschr 1966, 116:723-738.
2. Tao J., Van Esch H., Hagedorn-Greiwe M., Hoffmann K., Moser B., Raynaud M., Sperner J., Fryns J.P., Schwinger E., Gécz J., Ropers H.H., Kalscheuer V.M. Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation. Am J Hum Genet 2004, 75:1149-1154.
3. Scala E., Ariani F., Mari F., Caselli R., Pescucci C., Longo I., Meloni I., Giachino D., Bruttini M., Hayek G., Zappella M., Renieri A. CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasms. J Med Genet 2005, 42:103-107.
4. Ariani F., Hayek G., Rondinella D., Artuso R., Mencarelli M.A., Spanhol-Rosseto A., Pollazzon M., Buoni S., Spiga O., Ricciardi S., Meloni I., Longo I., Mari F., Broccoli V., Zappella M., Renieri A. FOXG1 is responsible for the congenital variant of Rett syndrome. Am J Hum Genet 2008, 83:89-93.
5. De Felice C., Ciccoli L., Leoncini S., Signorini C., Rossi M., Vannuccini L., Guazzi G., Latini G., Comporti M., Valacchi G., Hayek J. Systemic oxidative stress in classic Rett syndrome. Free Radic Biol Med 2009, 47:440-448.
6. Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 2003, 42:318-343.
7. Esterbauer H., Schaur R.J., Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991, 11:81-128.
8. Esterbauer H., Cheeseman K.H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Meth Enzymol 1990, 186:407-421.
9. Gutteridge J.M., Halliwell B. The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci 1990, 15:129-135.
10. Sies H., Cadenas E. Oxidative stress: damage to intact cells and organs. Philos Trans R Soc Lond B Biol Sci 1985, 311:617-631.
11. Tribble D.L., Aw T.Y., Jones D.P. The pathophysiological significance of lipid peroxidation in oxidative cell injury. Hepatology 1987, 7:377-386.
12. Forman H.J. Reactive oxygen species and alpha, beta-unsaturated aldehydes as second messengers in signal transduction. Ann N Y Acad Sci 2010, 1203:35-44.
13. Kostyuk V.A., Potapovich A.I., Cesareo E., Brescia S., Guerra L., Valacchi G., Pecorelli A., Deeva I.B., Raskovic D., De Luca C., Pastore S., Korkina L.G. Dysfunction of glutathione s-transferase leads to excess 4-hydroxy-2-nonenal and H2O2 and impaired cytokine pattern in cultured keratinocytes and blood of vitiligo patients. Antioxid Redox Signal 2010 Sep 1, 13(5):607-620.
14. Podborska M., Sevcikova A., Trna J., Dite P., Lojek A., Kubala L. Increased markers of oxidative stress in plasma of patients with chronic pancreatitis. Neuro Endocrinol Lett 2009, 30(Suppl 1):116-120.
15. Ansari M.A., Scheff S.W. Oxidative stress in the progression of Alzheimer disease in the frontal cortex. J Neuropathol Exp Neurol 2010, 69:155-167.
16. Uchida K., Toyokuni S., Nishikawa K., Kawakishi S., Oda H., Hiai H., Stadtman E.R. Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: markers for atherosclerosis. Biochemistry 1994, 33:12487-12494.
17. Humphries K.M., Szweda L.I. Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry 1998, 37:15835-15841.
18. Cohn J.A., Tsai L., Friguet B., Szweda L.I. Chemical characterization of a protein-4-hydroxy-2-nonenal crosslink: immunochemical detection in mitochondria exposed to oxidative stress. Arch Biochem Biophys 1996, 328:158-164.
19. De Luca C., Scordo M.G., Cesareo E., Pastore S., Mariani S., Maiani G., Stancato A., Loreti B., Valacchi G., Lubrano C., Raskovic D., De Padova L., Genovesi G., Korkina L.G. Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes. Toxicol Appl Pharmacol 2010, 248:285-292.
20. Poli G., Biasi F., Leonarduzzi G. 4-Hydroxynonenal-protein adducts: a reliable biomarker of lipid oxidation in liver diseases. Mol Aspects Med 2008, 29:67-71.
21. Montine K.S., Kim P.J., Olson S.J., Markesbery W.R., Montine T.J. 4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease. J Neuropathol Exp Neurol 1997, 56:866-871.
22. Ellis G., Fang E., Maheshwari M., Roltsch E., Holcomb L., Zimmer D., Martinez D., Murray I.V. Lipid oxidation and modification of amyloid-β (Aβ) in vitro and in vivo. J Alzheimers Dis 2010, [Epub ahead of print].
23. Mari F., Azimonti S., Bertani I., Bolognese F., Colombo E., Caselli R., Scala E., Longo I., Grosso S., Pescucci C., Ariani F., Hayek G., Balestri P., Bergo A., Badaracco G., Zappella M., Broccoli V., Renieri A., Kilstrup-Nielsen C., Landsberger N. CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome. Hum Mol Genet 2005, 14:1935-1946.
24. Perluigi M., Sultana R., Cenini G., Di Domenico F., Memo M., Pierce W.M., Coccia R., Butterfield D.A. Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: role of lipid peroxidation in Alzheimer's disease pathogenesis. Proteomics Clin Appl 2009, 3:682-693.