Early cardiac gene transcript levels in peripheral blood mononuclear cells in patients with untreated essential hypertension

Journal of Hypertension

Volumn 29, Issue 4, 2011, Pages 791-797

  Kontaraki, Joanna E ^a,b   Marketou, Maria E ^b   Zacharis, Evangelos A ^b   Parthenakis, Fragiskos I ^b   Vardas, Panos E ^b  

^a UNIVERSITY OF CRETE   (Greece)

^b UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

GATA4; hypertension; left ventricular mass index; myocardin; Nkx2.5

Indexed keywords

ADULT; ARTICLE; BLOOD PRESSURE MONITORING; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; FEMALE; GATA4 GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEART LEFT VENTRICLE MASS; HUMAN; HUMAN CELL; HYPERTROPHY; MAJOR CLINICAL STUDY; MALE; MARKER GENE; MEAN ARTERIAL PRESSURE; MYOCARDIN GENE; NKX2.5 GENE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PULSE PRESSURE; SYSTOLIC BLOOD PRESSURE; UPREGULATION;

EID: 79952762452     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e3283424bc4     Document Type: Article

References (38)

1. Frohlich E, Apstein C, Chobanian A, Devereux R, Dustan H, Dzau V, et al. The heart in hypertension. N Engl J Med 1992; 3:998-1008.
2. Diez J,Gonzalez A, Lopez B,Querejeta R.Mechanismsof disease: pathologic structural remodeling ismore than adaptive hypertrophy in hypertensive heart disease. Nat Clin Pract Cardiovasc Med 2005; 2:209-216.
3. Artham SM, Lavie CJ, Milani RV, Patel DA, Verma A, Ventura HO. Clinical impact of left ventricular hypertrophy and implications for regression. Prog Cardiovasc Dis 2009; 52:153-167.
4. Oka T, Xu J, Molkentin JD. Re-employment of developmental transcription factors in adult heart disease. Semin Cell Develop Biol 2007; 18:117-131. (Pubitemid 46330840)
5. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 2004; 84:767-801. (Pubitemid 38823766)
6. Wang D-Z, Olson EN. Control of smooth muscle development by the myocardin family of transcriptional coactivators. Curr Opin Genet Develop 2004; 14:558-566. (Pubitemid 39360304)
7. Wang Z, Wang D-Z, PipesGCT, Olson EN. Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad Sci 2003; 100:7129-7134. (Pubitemid 36706404)
8. Liu Z-P, Wang Z, Yanagisawa H, Olson EN. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Develop Cell 2005; 9:261-270. (Pubitemid 41051744)
9. Parmacek MS. Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation. Circ Res 2007; 100:633-644. (Pubitemid 46594877)
10. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25:1105-1187. (Pubitemid 46924065)
11. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification. Eur J Echocardiogr 2006; 7:79-108. (Pubitemid 43257193)
12. Schiller N, Shah P, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by twodimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two- Dimensional Echocardiograms. J Am Soc Echocardiogr 1989; 2:358-367.
13. Devereux R, Reichek N. Echocardiographic determination of left ventricular mass in man: anatomic validation of the method. Circulation 1977; 55:613-618. (Pubitemid 8066109)
14. Jan HS, Kerstin EL, Ivo RB, Thomas U, Heiko F-K. Quantitative real-time RTPCR data analysis: current concepts and the novel 'gene expression's CT difference' formula. J Mol Med 2006; V84:901-910.
15. Kontaraki JE, Parthenakis FI, Patrianakos AP, Karalis IK, Vardas PE. Altered expression of early cardiac marker genes in circulating cells of patients with hypertrophic cardiomyopathy. Cardiovasc Pathol 2007; 16:329-335. (Pubitemid 350086970)
16. Du KL, Ip HS, Li J, Chen M, Dandre F, Yu W, et al. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol 2003; 23:2425-2437. (Pubitemid 36351024)
17. Li S, Wang D-Z, Wang Z, Richardson JA, Olson EN. The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci 2003; 100:9366-9370. (Pubitemid 37033934)
18. Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD. Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy: compensation and myocyte viability. Circ Res 2006; 98:837-845.
19. Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, et al. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest 2007; 117:3198-3210. (Pubitemid 350096978)
20. Pickering TG, Shimbo D, Haas D. Ambulatory blood-pressure monitoring. N Engl J Med 2006; 354:2368-2374.
21. Vij R, Peixoto AJ. Management of nocturnal hypertension. Expert Rev Cardiovasc Therapy 2009; 7:607-618.
22. Ohkubo T, Hozawa A, Yamaguchi J, KikuyaM, Ohmori K, Michimata M, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertens 2002; 20:2183-2189. (Pubitemid 35388236)
23. Muxfeldt ES, Salles GF. Pulse pressure or dipping pattern: which one is a better cardiovascular risk marker in resistant hypertens? J Hypertens 2008; 26:878-884. (Pubitemid 351520974)
24. García-Ortiz L, Gómez-Marcos MA, Martín-Moreiras J, Gonzá lez-Elena LJ, Recio-Rodriguez JI, Castañ o-Sánchez Y, et al. Pulse pressure and nocturnal fall in blood pressure are predictors of vascular, cardiac and renal target organ damage in hypertensive patients (LOD-RISK study). Blood Press Monit 2009; 14: 145-151.
25. Aziz H, Zaas A, Ginsburg G. Peripheral blood gene expression profiling for cardiovascular disease assessment. Genomic Med 2007; 1:105-112.
26. Burczynski ME, Dorner AJ. Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies. Pharmacogenomics 2006; 7:187-202.
27. Liew C-C, Ma J, Tang H-C, Zheng R, Dempsey AA. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med 2006; 147:126-132. (Pubitemid 43288168)
28. Bruneau BG. Transcriptional regulation of vertebrate cardiac morphogenesis. Circ Res 2002; 90:509-519. (Pubitemid 34640900)
29. Srivastava D. Making or breaking the heart: from lineage determination to morphogenesis. Cell 2006; 126:1037-1048. (Pubitemid 44380303)
30. Kontaraki JE, Parthenakis FI, Nyktari EG, Patrianakos AP, Vardas PE. Myocardial gene expression alterations in peripheral blood mononuclear cells of patients with idiopathic dilated cardiomyopathy. Eur J Heart Failure 2010; 12:541-548.
31. Van Tuyn J, Knaan-Shanzer S, van de Watering MJM, de Graaf M, van der Laarse A, SchalijMJ, et al. Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin. Cardiovasc Res 2005; 67:245-255. (Pubitemid 40943617)
32. Quevedo HC, Hatzistergos KE, Oskouei BN, Feigenbaum GS, Rodriguez JE, Valdes D, et al. Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci 2009; 106:14022-14027.
33. Kucia M, Dawn B, Hunt G, Guo Y, Wysoczynski M, Majka M, et al. Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction. Circ Res 2004; 95:1191-1199. (Pubitemid 39648210)
34. Wojakowski W, Tendera M, Kucia M, Zuba-Surma E, Paczkowska E, Ciosek J, et al. Mobilization of bone marrow-derived Oct-4\+ SSEA-4\+ very small embryonic-like stem cells in patients with acute myocardial infarction. J Am Coll Cardiol 2009; 53:1-9.
35. Kontaraki JE, Parthenakis FI, Patrianakos AP, Karalis IK, Vardas PE. Myocardin gene regulatory variants as surrogate markers of cardiac hypertrophy: study in a genetically homogeneous population. Clin Genet 2008; 73:71-78. (Pubitemid 350263524)
36. Rajabi M, Kassiotis C, Razeghi P, Taegtmeyer H. Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Failure Rev 2007; 12:331-343. (Pubitemid 350176706)
37. Diez J, Frohlich ED. A translational approach to hypertensive heart disease. Hypertension 2010; 55:1-8.
38. Visvikis-Siest S, Marteau J-B, Samara A, Berrahmoune H, Marie Br, Pfister Ml. Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems. Clin Chem Lab Med 2007; 45:1154-1168. (Pubitemid 47396267)