Epigallocatechin-3-gallate inhibits lactase but is alleviated by salivary proline-rich proteins

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 6, 2011, Pages 2734-2738

  Naz, Shahina ^a   Siddiqi, Rahmanullah ^a   Dew, Tristan P ^b   Williamson, Gary ^b  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

amylase; enzyme inhibition; epigallocatechin gallate; lactase; protease; Salivary proline rich proteins

Indexed keywords

DIGESTIVE ENZYMES; EPIGALLOCATECHIN GALLATE; EPIGALLOCATECHIN-3-GALLATE; GREEN TEA; IN-VITRO; LACTASE; PROLINE-RICH PROTEINS; PROTEASE; SALIVARY PROLINE-RICH PROTEINS;

AMINO ACIDS; AMYLASES; CATALYSTS; ENZYMES; HYDROLASES; HYDROLYSIS; PROTEOLYSIS; SUGARS;

ENZYME INHIBITION;

CATECHIN; DRUG DERIVATIVE; ENZYME INHIBITOR; EPIGALLOCATECHIN GALLATE; LACTASE; LACTOSE; PLANT EXTRACT; PROLINE RICH PROTEIN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CATTLE; CHEMISTRY; DIGESTION; DOWN REGULATION; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; KINETICS; METABOLISM; RAT; SMALL INTESTINE; TEA;

ANIMALS; CATECHIN; CATTLE; DIGESTION; DOWN-REGULATION; ENZYME INHIBITORS; HUMANS; INTESTINE, SMALL; KINETICS; LACTASE; LACTOSE; MODELS, BIOLOGICAL; PLANT EXTRACTS; RATS; SALIVARY PROLINE-RICH PROTEINS; TEA;

EID: 79952759581     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf103072z     Document Type: Article

References (36)

1. Williamson, G.; Manach, C. Bioavailibility and bioefficacy of polyphenols in humans II. Review of 93 intervention studies Am. J. Clin. Nutr. 2005, 81, 243S-255S
2. Vita, J. A. Polyphenols and cardiovascular disease: Effects on endothelial and platelet function Am. J. Clin. Nutr. 2005, 81, 292S-297S
3. Simonyi, A.; Wang, Q.; Miller, R. L.; Yusof, M.; Shelat, P. B.; Sun, A. Y.; Sun, G. Y. Polyphenols in cerebral ischemia: Novel targets for neuroprotection Mol. Neurobiol. 2005, 31, 135-147 (Pubitemid 41271199)
4. Hara, Y.; Honda, M. The inhibition of α-amylase by tea polyphenols Agric. Biol. Chem. 1990, 54, 1939-1945
5. Carmona, A.; Borgudd, L.; Borgers, G.; Levy-Benshimol, A. Effect of black bean tannins on in vitro carbohydrate digestion and absorption J. Nutr. Biochem. 1996, 7, 445-450 (Pubitemid 26301997)
6. He, Q.; Lv, Y; Yao, K. Effect of tea polyphenols on the activities of α-amylase, pepsin, trypsin and lipase Food Chem. 2006, 101, 1178-1182 (Pubitemid 44416505)
7. Chauhan, A.; Gupta, S.; Mahmood, A. Effect of tannic acid on brush border disaccharide in mammalian intestine Indian J. Exp. Biol. 2007, 45, 353-358
8. McDougall, G. J.; Kulkarni, N. N.; Stewart, D. Berry polyphenols inhibit pancreatic lipase activity in vitro Food Chem. 2009, 115, 193-199
9. Zhang, L.; Li, J.; Hogan, S.; Chung, H.; Welbaum, G. E.; Zhou, K. Inhibitory effect of raspberries on starch digestive enzyme and their antioxidant properties and phenolic composition Food Chem. 2010, 119, 592-599
10. Charlton, A. J.; Baxter, N. J.; Lilley, T. H.; Haslam, E.; McDonald, C. J.; Williamson, M. P. Tannin interactions with a full-length human salivary proline rich protein display a stronger affinity than with single proline-rich repeats FEBS Lett. 1996, 382, 289-292 (Pubitemid 26092199)
11. Mehansho, H.; Anan, D. K.; Butler, L. G.; Rogler, J.; Carlson, D. M. Dietary tannins and salivary proline-rich proteins: Interactions, induction and defence mechanisms Ann. Rev. Nutr. 1987, 7, 423-440
12. Hagerman, A. E.; Butler, L. G. The specificity of proanthocyanidin- protein interactions J. Biol. Chem. 1981, 256, 4494-4497
13. Day, A. J.; Caňada, F. J.; Kroon, P. A.; Metauchlan, R.; Faulds, C. B.; Plumb, G. W.; Morgan, M. R.; Williamson, G. Dietary flavonoid and isoflavone glycosides are hydrolyzed by the lactase site of lactose phlorizin hydrolase FEBS Lett. 2000, 468, 166-170 (Pubitemid 30110789)
14. Guo, Q.; Zhao, B.; Shen, S.; Hou, J.; Hu, J.; Xin, W. ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers Biochim. Biophys. Acta 1999, 1427, 13-23 (Pubitemid 29123856)
15. Brown, M. K.; Evans, J. L.; Luo, Y. Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age dependent behavioral declines in Caenorhabditis elegans Pharmacol. Biochem. 2006, 85, 620-628 (Pubitemid 46097073)
16. Robbins, C. T.; Mole, S.; Hagerman, A. E.; Hanley, T. A. Role of tannins in defending plants against ruminants: Reduction in dry matter digestion Ecology 1987, 68, 1606-1615
17. Muenzer, J.; Bildstein, G.; Gleason, M.; Carlson, D. M. Properties of proline-rich proteins from parotid glands of isoproterenol-treated rats J. Biol. Chem. 1979, 245, 5629-5634 (Pubitemid 9245795)
18. Anson, M. L. The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin J. Gen. Physiol. 1938, 22, 79-89
19. Simon, M. L.; Kotorman, M.; Garab, G.; Laczko, I. Structure and activity of α-chymotrypsin and trypsin in aqueous organic media Biochem. Biophys. Res. Commun. 2001, 280, 1367-1371 (Pubitemid 32917796)
20. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 1976, 72, 248-254
21. Björck, I. M.; Nyman, M. E. In vitro effects of phytic acid and polyphenols on starch digestion and fiber degradation J. Food Sci. 1987, 52, 1588-1594
22. Dowd, J.; Riggs, D. S. A comparison of estimates of Michaelis-Menten kinetic constants from various linear transformations J. Biol. Chem. 1965, 240, 863-869
23. Oomen, A. G.; Rompelberg, C. J. M.; Bruil, M. A.; Dobbe, C. J. G.; Pereboom, D. P. K. H.; Sips, A. J. A. M. Develoment of an in vitro digestion model for estimating the bioaccessibility of soil contaminants Arch. Environ. Contam. Toxicol. 2003, 44, 281-287 (Pubitemid 36278396)
24. LaemmLi, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 1970, 227, 680-685
25. Krul, C.; Luiten-Schuite, A.; Tenfelde, A.; Ommen, B.; Verhagen, H.; Havenaar, R. Antimutagenic activity of green tea and black tea extracts studied in a dynamic in vitro gastrointestinal model Mutat. Res., Fundam. Mol. Mech. Mutagen. 2001, 474, 71-85 (Pubitemid 32184756)
26. Huang, H.; Kwok, K.-C.; Liang, H. Effects of tea polyphenols on the activities of soybean trypsin inhibitors and trypsin J. Sci. Food Agric. 2004, 84, 121-126 (Pubitemid 38162074)
27. Landis-Piwowar, K. R.; Wan, S. B.; Wiegand, R. A.; Kuhn, D. J.; Chan, T. H.; Dou, Q. P. Methylation suppresses the proteasome-inhibitory function of green tea polyphenols J. Cell. Physiol. 2007, 213, 525-260
28. Tagliazucchi, D.; Verzelloni, E.; Conte, A. Effect of some phenolic compounds and beverages on pepsin activity during simulated gastric digestion J. Agric. Food Chem. 2005, 53, 8706-8713 (Pubitemid 41608934)
29. Piparo, E. L.; Scheib, H.; Frei, N.; Williamson, G.; Grigorov, M.; Chou, C. J. Flavonoids for controlling starch digestion; structural requirement for inhibiting human α-amylase J. Med. Chem. 2008, 51, 3555-3561 (Pubitemid 351875010)
30. Baxter, N. J.; Lilley, T. H.; Haslan, E.; Williamson, M. P. Multiple interactions between polyphenols and a salivary-rich protein repeat result in complexation and precipitation Biochemistry 1997, 36, 5566-5577 (Pubitemid 27200055)
31. Williamson, M. P. The structure and function of proline-rich regions in proteins Biochem. J. 1994, 297, 249-260 (Pubitemid 24026414)
32. Shinnar, A. E.; Butler, K. L.; Park, H. J. Cathelicidin family of antimicrobial peptides: Proteolytic processing and protease resistance Bioorg. Chem. 2003, 31, 425-436 (Pubitemid 37378217)
33. Lu, Y.; Bennick, A. Interaction of tannins with human salivary proline-rich proteins Arch. Oral Biol. 1998, 43, 717-728 (Pubitemid 28427628)
34. Cheplick, S.; Kwon, Y.-I.; Bhownik, P.; Shetty, K. Phenolic-linked variations in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension Bioresour. Technol. 2010, 101, 404-413
35. Jia, Q.; Lia, X.; Wu, X.; Wang, R.; Hu, X.; Li, Y.; Huang, C. Hypoglycemic activity of polyphenolic oligomer-rich extract of Cinnamomum parthenoxylon bark in normal and streptozotocin-induced diabetes rats Phytomedicine 2009, 16, 744-750
36. Rawel, H. M.; Frey, S.; Meidtner, K.; Kroll, J.; Schweigert, F. J. Determining the binding affinities of phenolic compounds to proteins by quenching of the intrinsic tryptophan fluorescence Mol. Nutr. Food Res. 2006, 50, 705-713 (Pubitemid 44342467)