TRAPping telomerase within the intestinal stem cell niche

EMBO Journal

Volumn 30, Issue 6, 2011, Pages 986-987

  Pech, Matthew F ^a   Artandi, Steven E ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOPROTEIN; TELOMERASE;

ARTICLE; CELL DIFFERENTIATION; CHROMOSOME SEGREGATION; GENOME; HUMAN; INTESTINE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL NICHE; TELOMERE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CHROMOSOME SEGREGATION; EPITHELIAL CELLS; INTESTINAL MUCOSA; MICE; STEM CELL NICHE; STEM CELLS; TELOMERASE; TIME FACTORS;

EID: 79952749359     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.51     Document Type: Article

References (10)

1. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007 (Pubitemid 350014593)
2. Cairns J (1975) Mutation selection and the natural history of cancer. Nature 255: 197-200
3. Falconer E, Chavez EA, Henderson A, Poon SS, McKinney S, Brown L, Huntsman DG, Lansdorp PM (2010) Identification of sister chromatids by DNA template strand sequences. Nature 463: 93-97
4. Montgomery RK, Carlone DL, Richmond CA, Farilla L, Kranendonk ME, Henderson DE, Baffour-Awuah NY, Ambruzs DM, Fogli LK, Algra S, Breault DT (2011) Mouse telomerase reverse transcriptase (mTERT) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci USA 408: 179-184
5. Morrison SJ, Prowse KR, Ho P, Weissman IL (1996) Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5: 207-216 (Pubitemid 26341364)
6. Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE (2009) Telomerase modulates Wnt signaling by association with target gene chromatin. Nature 460: 66-72
7. Quyn AJ, Appleton PL, Carey FA, Steele RJ, Barker N, Clevers H, Ridgway RA, Sansom OJ, Näthke IS (2010) Spindle orientation bias in gut epithelial stem cell compartments is lost in precancer-ous tissue. Cell Stem Cell 6: 175-181
8. Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H (2011) Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469: 415-418
9. Schepers AG, Vries R, van den Born M, van de Wetering M, Clevers H (2011) Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. EMBO J 30: 1104-1109
10. Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA (2000) Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet 26: 85-88