Generation of biologically active nano-aerosol by an electrospray-neutralization method

Journal of Aerosol Science

Volumn 42, Issue 5, 2011, Pages 341-354

  Morozov, Victor N ^a,b  

^a GEORGE MASON UNIVERSITY   (United States)

^b INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

Author keywords

Electrospray; Enzyme; Nano aerosol; Neutralization

Indexed keywords

ENZYMES; NANOCLUSTERS;

ELECTROSPRAYS; NEUTRALIZATION; NEUTRALIZATION METHODS; NEW APPLICATIONS; POLYMER CONCENTRATIONS; SINGLE POLYMER MOLECULES; SPECIFIC ACTIVITY; VOLATILE SOLVENTS;

AEROSOLS;

NANOPARTICLE; POLYMER; RADIOACTIVE AEROSOL; SOLVENT; VOLATILE AGENT;

AEROSOL COMPOSITION; GAS PHASE REACTION; HUMIDITY; NEUTRALIZATION; POLYMER; SOLVENT; VOLCANIC CLOUD;

AEROSOL; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY; ENZYME ACTIVITY; MACROMOLECULE; NONHUMAN; PRIORITY JOURNAL; SYNTHESIS;

EID: 79952734298     PISSN: 00218502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaerosci.2011.02.008     Document Type: Article

References (41)

1. Alexandrov M.L., Gall' L.N., Krasnov M.V., Nikolaev V.I., Pavelenko V.A., Shkurov V.A. Ion extraction from solutions at atmospheric pressure-a method for mass-spectrometric analysis for mass-spectrometric analysis of bioorganic substances. Doklady Akademii Nauk SSSR 1984, (277):379-383.
2. Almekinders J.C., Jones C. Multiple jet electrohydrodynamic spraying and applications. Journal of Aerosol Science 1999, 30:969-971.
3. Avseenko N.V., Morozova T.Ya., Ataullakhanov F.I., Morozov V.N. Immunoassay with multicomponent microarrays fabricated by electrospray deposition. Analytical Chemistry 2002, 74:927-933.
4. Bacher G., Szymanski W.W., Kaufman S.L., Zöllner P., Blaas D., Allmaier G. Charge-reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses. Journal of Mass Spectrometry 2001, 36:1038-1052.
5. Basak S., Chen D.R., Biswas P. Electrospray of ionic precursor solutions to synthesize iron oxide nanoparticles: Modified scaling law. Chemical Engineering Science 2007, 62:1263-1268.
6. Bukatina A.E., Morozov V.N., Gusev N.B., Sieck G.C. Mechano-chemical effects of Ca2+ in cross-linked troponin-C films. FEBS Letters 2002, 524:107-110.
7. Camelot D., Marijnissen J.C.M., Scarlett B. Bipolar coagulation process for the production of powders. Industrial and Engineering Chemical Research 1999, 38:631-638.
8. Carter D.C., Ho J.X. Structure of serum albumin. Advances in Protein Chemistry 1994, 45:153-203.
9. Corn M., Esman N.A. Aerosol generation. Handbook of Aerosols 1976, 9-39. University Press of the Pacific, Honolulu, Hawaii. R. Dennis (Ed.).
10. De La Mora J.F., Navascues J., Fernandez F., Rosell-Llompart J. Generation of submicron monodisperse aerosols in electrosprays. Journal of Aerosol Science 1990, 21:673-676.
11. Dole M., Hines R.L., Mack L.L., Mobley R.C., Ferguson L.D., Alice M.B. Gas phase macroions. Macromolecules 1968, 1:96-97.
12. Fenn J. Electrospray ionization mass spectrometry: How it all began. Journal of Biomolecular Technology 2002, 13:101-118.
13. Fernandez de la Mora J. The fluid dynamics of Taylor Cones. Annual Review of Fluid Mechanics 2007, 39:217-243.
14. Frey B.L., Lin Y., Westphall M.S., Smith L.M. Controlling gas-phase reactions for efficient charge reduction electrospray mass spectrometry of intact proteins. Journal of the American Society of Mass Spectrometry 2005, 16:1876-1887.
15. Greiner A., Wendorf J.H. Electrospinning techniques. Angewandte Chemie International Edition 2007, 46:5670-5703.
16. Ijesebaert J.C., Geerse K.B., Marijnisseen J.C.M., Lammers J.W.J., Zanen P. Electro-hydrodynamic atomization of drug solutions for inhalation purposes. Journal of Applied Physiology 2001, 91:2735-2741.
17. Kebarle P. A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry. Journal of Mass Spectrometry 2000, 35:804-817.
18. Kozenkov V.I., Fuks N.A. Electrohydrodynamic atomization of liquids. Russian Chemical Reviews 1976, 45:1179-1184.
19. Krasnov N.V., Shevchenko S.I. Comprehensive studies of electrohydrodynamic spraying of liquids. Review of Scientific Instruments 1995, 66:3623-3626.
20. Landt M., Boltz S.C., Butler L.G. Alkaline phosphatase: Affinity chromatography and inhibition by phosphonic acids. Biochemistry 1978, 17:915-919.
21. Li D., Xia Y. Electrospinning of nanofibers: Reinventing the wheel. Advanced Materials 2004, 16:1151-1170.
22. Morozov V.N., Morozova T.Ya. Electrospray deposition as a method for mass fabrication of mono- and multi-component microarrays of biological and biologically active substances. Analytical Chemistry 1999, 71:3110-3117.
23. Morozov V.N., Morozova T.Ya. Electrospray deposition as a method to fabricate functionally active protein films. Analytical Chemistry 1999, 71:1415-1420.
24. Morozov V.N. Electrospray deposition of biomolecules. Chapter in: Advances in biochemical engineering/biotechnology 2010, Vol. 119. Springer Science+Business Media, (pp. 115-162).
25. Morozov V.N., Morozova T.Ya., Kallenbach N.R. Atomic force microscopy of structures produced by electrospray of synthetic and natural linear polymers. International Journal of Mass Spectrometry and Ion Processes 1998, 178:143-159.
26. Morozov V.N., Vsevolodov N.N. Electrospray-neutralization method for manufacturing free and supported nanomats. Advanced Materials 2007, 19:4381-4386.
27. Nagato K., Matsui T., Miyata T., Yamauchi T. An analysis of the evolution of negative ions produced by a corona ionizer in air. International Journal of Mass Spectrometry 2006, 248:142-147.
28. Olumee Z., Callahan J.H., Vertes A. Droplet dynamics changes in electrostatic sprays of methanol-water mixtures. Journal of Physical Chemistry 1998, 102:9154-9160.
29. Pöschl U. Atmospheric aerosols: Composition, transformation, climate and health effects. Angewandte Chemie 2005, 44:7520-7540.
30. Salata O.V. Tools of nanotechnology: Electrospray. Current Nanoscience 2005, 1:25-33.
31. Scalf M., Westphall M.S., Krause J., Kaufman S.L., Smith L.M. Controlling charge states of large ions. Science 1999, 283:194-197.
32. Siu K.W.M., Guevremont R., Le Blanc J.C.Y., O'Brien R.T., Berman S.S. Is droplet evaporation crucial in the mechanism of electrospray mass spectrometry?. Organic Mass Spectrometry 1993, 28:579-584.
33. Stein P.E., Leslie A.G.W., Finch J.T., Carrell R.W. Crystal structure of uncleaved ovalbumin at 1.95A° resolution. Journal of Molecular Biology 1991, 221:941-959.
34. Tang K.Q., Gomez A. Generation of monodisperse water droplets from electrosprays in a corona-assisted cone-jet mode. Journal of Colloid and Interface Science 1995, 175:326-332.
35. Venter A., Sojka P.E., Cooks R.G. Droplet dynamics and ionization mechanisms in desorption electrospray ionization mass spectrometry. Analytical Chemistry 2006, 78:8549-8555.
36. Vetcher A.A., Gearheart R., Morozov V.N. Polyacrylamide-based material for electrospun humidity-resistant, water-soluble nanofilters. Polymers for Advanced Technologies 2008, 19:1276-1285.
37. Welle A.M., Jacobsa H.O. Printing of organic and inorganic nanomaterials using electrospray ionization and coulomb-force-directed assembly. Applied Physics Letter 2005, 87:263119.
38. Wong S.F., Meng S.K., Fenn J.B. Multiple charging in electrospray ionization of poly(ethylene glycols). Journal of Physical Chemistry 1988, 92:546-550.
39. Yamashita M., Fenn J.B. Negative ion production with the electrospray ion source. Journal of Physical Chemistry 1984, 88:4671-4675.
40. Zeleny J. Instability of electrified liquid surface. Physical Review 1917, 10:1-6.
41. Zolotoi N.B., Karpov G.V., Skurat V.E. On the mechanism of formation of ions and cluster ions from charged droplets. Soviet Physics Technical Physics 1988, 33:193-198.