An exopolysaccharide from cultivated Cordyceps sinensis and its effects on cytokine expressions of immunocytes

Applied Biochemistry and Biotechnology

Volumn 163, Issue 5, 2011, Pages 669-678

  Sheng, Lu ^a   Chen, Jiaping ^a   Li, Jing ^a   Zhang, Weiyun ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Cultivated Cordyceps sinensis; Cytokine; Exopolysaccharide; Immunocyte

Indexed keywords

ANTITUMOR EFFECT; CORDYCEPS SINENSIS; CYTOKINE; CYTOKINE EXPRESSION; CYTOKINES; EXOPOLYSACCHARIDES; GEL FILTRATION; IMMUNOCYTE; INTERLEUKIN-2; MRNA LEVEL; MTT METHOD; PROTEIN EXPRESSION LEVELS; PROTEIN EXPRESSIONS; PROTEIN LEVEL; SEPHADEX; SPLENOCYTES; THYMOCYTES; TUMOR NECROSIS FACTOR ALPHA;

DRUG PRODUCTS; GELS; GLUCOSE; GLYCOPROTEINS; ION EXCHANGE; MOLECULAR WEIGHT; NUCLEIC ACIDS;

PROTEINS;

ALPHA INTERFERON; CYTOKINE; EXOPOLYSACCHARIDE; GALACTOSE; GLUCOSE; INTERLEUKIN 2; MANNOSE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; GEL FILTRATION; LYMPHOCYTE PROLIFERATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OPHIOCORDYCEPS; PROTEIN EXPRESSION; SPLEEN CELL; SPLEEN LYMPHOCYTE; THYMOCYTE;

ANIMALS; CELLS, CULTURED; CORDYCEPS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERFERON-ALPHA; INTERFERON-GAMMA; INTERLEUKIN-2; LYMPHOCYTES; MICE; POLYSACCHARIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPLEEN; THYMUS GLAND; TUMOR NECROSIS FACTOR-ALPHA;

CORDYCEPS SINENSIS; MUS;

EID: 79952709431     PISSN: 02732289     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12010-010-9072-3     Document Type: Article

References (22)

1. Moradali, M. F., Mostafavi, H., Ghods, S., & Hedjaroude, G. A. (2007). Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). International Immunopharmacology, 7, 701-724.
2. Chang, Y. H., Yang, J. S., Yang, J. L., Wu, C. L., Chang, S. J., Lu, K. W., et al. (2009). Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo. Bioscience, Biotechnology, and Biochemistry, 73, 2589-2594.
3. Hetland, G., Johnson, E., Lyberg, T., Bernardshaw, S., Tryggestad, A. M., & Grinde, B. (2008). Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer. Scandinavian Journal of Immunology, 68, 363-370.
4. Tzianabos, A. O. (2000). Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function. Clinical Microbiology Reviews, 13, 523-533.
5. Wasser, S. P. (2002). Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Applied Microbiology and Biotechnology, 60, 258-274.
6. Liu, J. J., Huang, T. S., Hsu, M. L., Chen, C. C., & Lin, W. S. (2004). Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action. Toxicology and Applied Pharmacology, 201, 186-193.
7. Zhao, H., Luo, Y., Lu, C., Lin, N., Xiao, C., Guan, S., et al. (2010). Enteric mucosal immune response might trigger the immunomodulation activity of Ganoderma lucidum polysaccharide in mice. Planta Medica, 76, 223-227.
8. Zhang, W. Y., Yang, J. Y., Chen, J. P., Hou, Y. Y., & Han, X. D. (2005). Immunomodulatory and antitumor effects of exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinense fungus on tumor-bearing mice. Biotechnology and Applied Biochemistry, 42, 9-11.
9. Zhang, W. Y., Li, J., Qiu, S. Q., Chen, J. P., & Zhen, Y. (2008). Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice. Fitoterapia, 79, 168-173.
10. Huang, D., Zhang, W., Huang, D., & Wu, J. (2010). Antitumor activity of the aqueous extract from Sedum sarmentosum Bunge in vitro. Cancer Biotherapy & Radiopharmaceuticals, 25, 81-88.
11. Heinrich, P. C., Behrmann, I., Muller-Newen, G., Schaper, F., & Graeve, L. (1998). Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. The Biochemical Journal, 334, 297-231.
12. Hacker, E., Muller, K., Whiteman, D. C., Pavey, S., Hayward, N., & Walke, G. (2008). Reduced expression of IL-18 is a marker of ultraviolet radiation-induced melanomas. International Journal of Cancer, 123, 227-231. (Pubitemid 351705213)
13. Heikkilä, K., Ebrahim, S., & Lawlor, D. A. (2008). Systematic review of the association between circulating interleukin-6 (IL-6) and cancer. European Journal of Cancer, 44, 937-945.
14. Ho, M. Y., Sun, G. H., Leu, S. J., Ka, S. M., Tang, S. J., & Sun, K. H. (2008). Combination of Fasl and GM-CSF confers synergistic antitumor immunity in an in vivo model of the murine Lewis lung carcinoma. International Journal of Cancer, 123, 123-133.
15. Vairaktaris, E., Yapijakis, C., Serefoglou, Z., Derka, S., Vassilio, S., Nkenke, E., et al. (2008). The interleukin-10 (-1082A/G) polymorphism is strongly associated with increased risk for oral squamous cell carcinoma. Anticancer Research, 28, 309-314. (Pubitemid 351362918)
16. Watanabe, N., Niitsu, Y., Umeno, H., Kuriyama, H., Neda, H., Yamauchi, N., et al. (1988). Toxic effect of tumor necrosis factor on tumor vasculature in mice. Cancer Research, 48, 2179-2183.
17. Ikeda, H., Old, L. J., & Schreiber, R. D. (2002). The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine & Growth Factor Reviews, 13, 95-109. (Pubitemid 34229385)
18. Kim, P. K., Armstrong, M., Liu, Y., Yan, P., Bucher, B., & Zuckerbraun, B. S. (2004). IRF-1 expression induces apoptosis and inhibits tumour growth in mouse mammary cancer cells in vitro and in vivo. Oncogene, 23, 1125-1135. (Pubitemid 38269966)
19. Bouker, K. B., Skaar, T. C., Riggins, R. B., Harburger, D. S., Fernandez, D. R., & Zwart, A. (2005). Interferon regulatory factor-1 (IRF-1) exhibits tumour suppressor activities in breast cancer associated with caspase activation and induction of apoptosis. Carcinogenesis, 26, 1527-1535. (Pubitemid 41244519)
20. Connett, J. M., Badri, L., Giordano, T. J., Connett, W. C., & Doherty, G. M. (2005). Interferon regulatory factor 1 (IRF-1) and IRF-2 expression in breast cancer tissue microarrays. Journal of Interferon and Cytokine Research, 25, 587-594. (Pubitemid 41507814)
21. Sidky, Y. A., & Borden, E. C. (1987). Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses. Cancer Research, 47, 5155-5161. (Pubitemid 17146488)
22. Rosenberg, S. A. (2001). Progress in human tumour immunology and immunotherapy. Nature, 411, 380-384.