Enteric mucosal immune response might trigger the immunomodulation activity of ganoderma lucidum polysaccharide in mice

Planta Medica

Volumn 76, Issue 3, 2010, Pages 223-227

  Zhao, Hongyan ^a   Luo, Yingying ^b   Lu, Cheng ^a   Lin, Na ^a   Xiao, Cheng ^c   Guan, Shuhong ^d   Guo, De An ^d   Liu, Zhenli ^b   Ju, Dahong ^a   He, Xiaojuan ^a   Lu, Aiping ^a,e  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^d SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^e SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Cytokines; Ganoderma lucidum; Ganoderma lucidum polysaccharide; Mucosal immune response; Polyporaceae

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 2; MESSENGER RNA; POLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GANODERMA LUCIDUM; GASTROINTESTINAL MUCOSA; IMMUNE RESPONSE; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PEYER PATCH; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; IMMUNOLOGIC FACTORS; INTERLEUKIN-10; INTERLEUKIN-2; INTESTINAL MUCOSA; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MICE; MICE, INBRED STRAINS; PEYER'S PATCHES; POLYSACCHARIDES; REISHI; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

FUNGI; GANODERMA LUCIDUM; MUS; POLYPORACEAE;

EID: 77049083640     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1186055     Document Type: Article

References (28)

1. Sliva D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev Med Chem 2004 4 873-879 (Pubitemid 39200074)
2. Jiang J, Slivova V, Valachovicova T, Harvey K, Sliva D. Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. Int J Oncol 2004 24 1093-1099
3. Liu Y, Geng Y. Study on cellular mechanisms and signaling pathway of antitumor activity of Ganoderma lucidum polysaccharide. Food Drug 2008 10 48-51
4. Li J J., Lei L S., Yu C L., Zhu Z G., Zhang Q, Wu S G. Effect of Ganoderma lucidum polysaccharide on tumor cell nucleotide content and cell cycle in S180 ascitic tumor-bearing mice. J South Med Univ 2007 27 1003-1005
5. Cao Q Z., Lin Z B. Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharide peptide. Acta Pharmacol Sin 2004 25 833-838
6. Hsu H Y., Hua K F., Lin C C., Lin C H., Hsu J, Wong C H. Extract of Reishi polysaccharide induces cytokine expression via TLR4-modulated protein kinase signaling pathways. J Immunol 2004 173 5989-5999
7. Lin Y L., Liang Y C., Lee S S., Chiang B L. Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways. J Leukoc Biol 2005 78 533-543
8. Kagnoff M F. Oral tolerance: mechanisms and possible role in inflammatory joint diseases. Baillieres Clin Rheumatol 1996 10 41-54
9. Cao Y. Anti-tumor actions of gamma-delta T lymphocytes. Int J Immunol 2006 29 357-360
10. Fan J. Intestinal mucosal immunity. Int J Immunol 2006 29 112-115
11. Xiao C, Lu C, Zhao L, Liu Z, Zhang W, He Y, Chen S, Tang J C., Chan A S., Lu A. The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis. Planta Med 2006 72 1268-1272
12. Huie C W., Di X. Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components. J Chromatogr B 2004 812 241-257
13. Ma C, Guan S H., Yang M, Liu X, Guo D A. Differential protein expression in mouse splenic mononuclear cells treated with polysaccharides from spores of Ganoderma lucidum. Phytomedicine 2008 15 268-276
14. Todd D, Singh A J., Greiner D L., Mordes J P., Rossini A A., Bortell R. A new isolation method for rat intraepithelial lymphocyte. J Immunol Methods 1999 224 111-127
15. Chan W K., Cheung C C., Law H K., Lau Y L., Chan G C. Ganoderma lucidum polysaccharide can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function. J Hematol Oncol 2008 21 1-12
16. Shao B M., Dai H, Xu W, Lin Z B., Gao X M. Immune receptors for polysaccharide from Ganoderma lucidum. Biochem Biophys Res Commun 2004 323 133-141
17. Lieu C W., Lee S S., Wang S Y. The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells. Anticancer Res 1992 12 1211-1215
18. Cao L Z., Lin Z B. Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides. Immunol Lett 2002 83 163-169
19. + NK-cell cytotoxicity in cord blood. Bioorg Med Chem 2004 12 5603-5609
20. Kunisawa J, Kiyono H. A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense. Cell Mol Life Sci 2005 62 1308-1321
21. Mowat A M., Viney J L. The anatomical basis of intestinal immunity. Immunol Rev 1997 156 145-166
22. Bloom P D., Boedeker E C. Mucosal immune responses to intestinal bacterial pathogens. Semin Gastrointest Dis 1996 7 151-166
23. Stern J B., Smith K A. Interleukin-2 induction of T-cell G1 progression and c-myb expression. Science 1986 233 203-206
24. Beadling C, Johnson K W., Smith K A. Isolation of interleukin 2-induced immediate-early genes. Proc Natl Acad Sci USA 1993 90 2719-2723
25. Beadling C, Smith K A. DNA array analysis of interleukin-2-regulated immediate/early genes. Med Immunol 2002 1 1-14
26. Waldmann T A. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol 2006 6 595-601
27. Moore K W., de Waal Malefyt R, Coffman R L., O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001 19 683-765
28. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10- deficient mice develop chronic enterocolitis. Cell 1993 75 263-274