Evaluation of reproductive/developmental and repeated dose (subchronic) toxicity and cytogenetic effects in rats of a roofing asphalt fume condensate by nose-only inhalation

Regulatory Toxicology and Pharmacology

Volumn 59, Issue 3, 2011, Pages 445-453

  Parker, C M ^a   Schreiner, C A ^b   Hallmark, N ^c   Kriech, A J ^d   Osborn, L V ^d   Fuhst, R ^e   Buschmann, J ^e   Ernst, H ^e   Hansen, T ^e   Pohlmann, G ^e   Preiss, A ^e   Ziemann, Ch ^e  

^a Marathon Petroleum (Retired)   (United States)

^b C and C Consulting in Toxicology   (United States)

^c EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^d Heritage Research Group   (United States)

^e FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Asphalt; Bitumen; Cytogenetics; Developmental reproduction; Fume condensate; Inhalation; Micronucleus; Polycyclic aromatic hydrocarbons

Indexed keywords

ASPHALT; POLYCYCLIC AROMATIC HYDROCARBON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONIC TOXICITY; CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; ERYTHROCYTE; FEMALE; FOOD INTAKE; FUME; HISTOPATHOLOGY; LUNG WEIGHT; MALE; MICRONUCLEUS; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; TOXIC INHALATION; TOXICITY; WEIGHT GAIN;

ADMINISTRATION, INHALATION; ADMINISTRATION, INTRANASAL; ANIMALS; BODY WEIGHT; CYTOGENETIC ANALYSIS; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; ENVIRONMENTAL MONITORING; FEMALE; HYDROCARBONS; INHALATION EXPOSURE; LUNG; MALE; PREGNANCY; RATS; RATS, WISTAR; REPRODUCTION;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 79952708261     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.01.010     Document Type: Article

References (18)

1. AI [Asphalt Institute], 1990. Report to OSHA and NIOSH: Appendix C - a critical review of the toxicology of asphalt fumes. ENSR Consulting and Engineering, Lexington, KY. 16pp.
2. API [American Petroleum Institute], 2009. American Petroleum Institute Category Assessment Documents, http://www.petroleumhpv.org/pages/asphalt.html.
3. Brandt H., DeGroot P. Sampling and analysis of bitumen fumes. Part 3: laboratory study of emissions under controlled conditions. Ann. Occup. Hyg. 1985, 29(1):42-46.
4. Burgaz S., et al. Cytogenetic biomonitoring of workers exposed to bitumen fumes. Mutat. Res. 1998, 419(1-3):123-130.
5. Fraunhofer ITA. 2001. 13-week inhalation toxicity study of bitumen fumes in Wistar (WU) rats. Study No. 02G01005. R. Fuhst, Study Director. Fraunhofer Institute of Toxicology, and Aerosol Research, Drug Research and Clinical Inhalation, Hannover, Germany.
6. Fraunhofer ITEM. 2008. Chamber Trials for the Combined Repeated Dose Toxicity Study with Reproductive/Developmental Screening Test and Mammalian Erythrocyte Micronucleus Test via Inhalation with Roofing Asphalt fume condensate. Fraunhofer ITEM Study # 02N07532 Hannover, Germany. Sponsored by Petroleum HPV Testing Group, API, Washington, DC.
7. Fuhst R., et al. 24 Months inhalation carcinogenicity study of bitumen fumes in Wistar (WU) rats. J. Occup. Environ. Hyg. 2007, 4(S1):20-43.
8. Halter R., et al. Importance of DNA adduct formation and gene expression profiling of disease candidate genes in rats exposed to bitumen fumes. J. Occup. Environ. Health 2007, 4(Suppl. 1):44-64.
9. Jarvholm B., et al. Exposure of polycyclic aromatic hydrocarbons and genotoxic effects on nonsmoking Swedish road pavement workers. Scand. J. Work Environ. Health 1999, 25:131-136.
10. Kriech, A. J., Collection, Validation and Generation of Asphalt Roofing Fumes for Reproductive/Developmental Toxicity Study, Prepared for the American Petroleum Institute HPV Testing Group Consortium Registration #1100997, Study conducted by Heritage Research Group, Final Report, February 3, 2006.
11. Kriech A.J., Osborn L.V., Trumbore D.C., Kurek J.T., et al. Evaluation of worker exposure to asphalt roofing fumes: influence of work practices, materials and environmental conditions. J. Occup. Environ. Hyg. 2004, 1:88-98.
12. Kriech A.J., Osborn L.V., Wissel H.L., et al. Generation of bitumen fumes using two fume generation protocols and comparison to worker industrial hygiene exposures. J. Occup. Environ. Hyg. 2007, 4(1):6-19.
13. Kriech A.J., Emmel C., Osborn L.V., et al. Side by side comparison of field monitoring methods for hot bitumen emission exposures: the German BGIA method 6305, the US NIOSH method 5042 and the total organic matter method. J. Occup. Environ. Hyg. 2010, 7:712-725.
14. Ma J., et al. Alteration of pulmonary cytochrome P-450 system: effects of asphalt fume condensate exposure. J. Toxicol. Environ. Health [a] 2002, 65:1247-1260.
15. Murray E., Edwards J. Differential induction of micronuclei in peripheral lymphocytes and exfoliated urothelial cells of workers exposed to 4,4'-methylenebis-(2-chloroaniline) (MOCA) and bitumen fumes. Rev. Environ. Health 2005, 20(3):163-176.
16. Olsson, A., H. et al. 2010. A Case-Control Study of Lung Cancer Nested in a Cohort of European Asphalt Workers. Environ. Health Perspect. 118, 1418-1424.
17. Wess A.L., Olsen L.D., Sweeney M.H. Asphalt (Bitumen). Concise International Chemical Assessment Document 59 2004, NIOSH, Cincinnati, Ohio.
18. Zhao H., et al. Effects of paving asphalt fume exposure on genotoxic and mutagenic activities in the rat lung. Mutat. Res. 2004, 557(2):137-149.