In vivo anti-tussive activity and structural features of a polysaccharide fraction from water extracted Withania somnifera

Journal of Ethnopharmacology

Volumn 134, Issue 2, 2011, Pages 510-513

  Sinha, Sharmistha ^a   Nosál'Ová, Gabriella ^b   Bandyopadhyay, Shruti S ^a   Flešková, Dana ^b   Ray, Bimalendu ^a  

^a UNIVERSITY OF BURDWAN   (India)

^b University Hospital in Martin   (Slovakia)

Author keywords

Anti tussive activity; Cough; Pectic arabinogalactan; Withania somnifera

Indexed keywords

ARABINOGALACTAN; ARABINOSE; CODEINE; FUCOSE; GALACTOSE; GLUCOSE; RHAMNOSE; WATER; WITHANIA SOMNIFERA EXTRACT;

AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANION EXCHANGE CHROMATOGRAPHY; ANTITUSSIVE ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; COUGHING; DRUG ACTIVITY; DRUG MECHANISM; GUINEA PIG; IN VIVO STUDY; MALE; NONHUMAN; SMOOTH MUSCLE RELAXATION; SPASMOLYSIS; WITHANIA SOMNIFERA;

ANIMALS; ANTITUSSIVE AGENTS; BEHAVIOR, ANIMAL; CITRIC ACID; CODEINE; COUGH; GALACTANS; GUINEA PIGS; PHYTOTHERAPY; PLANT EXTRACTS; WITHANIA;

CAVIA; WITHANIA SOMNIFERA;

EID: 79952703421     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.12.022     Document Type: Article

References (16)

1. Ahmed, A., Labavitch, J.M., 1977. A simplified method for accurate determination of cell wall uronide content. Journal of Food Biochemistry 1, 361-365.
2. Belvisi, M.G., Hele, D.J., 2009. Cough sensors III. Opioid and cannabinoid receptors on vagal sensory nerves. In: Chung, K.F., Widdicombe, J.G. (Eds.), Handbook of Experimental Pharmacology and Therapeutics of Cough. Springer-Verlag, Heidelberg, pp. 263-276.
3. Berteau, O., Mulloy, B., 2003. Sulfated fucans, fresh perspectives: structures, functions and biological functions of sulfated fucans and an overview of enzymes active towards this class of polysaccharides. Glycobiology 13, 29-40.
4. Blakeney, A.B., Harris, P., Henry, R.J., Bruce, A.B., 1983. A simple rapid preparation of alditol acetates for monosaccharide analysis. Carbohydrate Research 113, 291-299.
5. Blakeney, A.B., Stone, B.A., 1985. Methylation of carbohydrates with lithium methylsulphinyl carbanion. Carbohydrate Research 140, 319-324.
6. Chung, K.F., 2009. Clinical cough VI: the need for new therapies for cough: disease-specific and symptom-related anti-tussives. In: Chung, K.F., Widdicombe, J.G. (Eds.), Handbook of Experimental Pharmacology. Springer-Verlag, Heidelberg, pp. 343-368.
7. Dubois, M., Gilles, K.A., Hamilton, J.K., Rebers, P.A., Smith, F., 1956. Colorimetric method for determination of sugars and related substances. Analytical Chemistry 28, 350-366.
8. Ghosh, T., Chattopadhyay, K., Marschall, M., Karmakar, P., Mandal, P., Ray, B., 2009. Focus on anti-virally active sulfated polysaccharides: from structure-activity analysis to clinical evaluation. Glycobiology 19, 2-15.
9. Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, Delhi.
10. Kulkarni, S.K., Dhir, A., 2008. Withania somnifera: an Indian ginseng. Progress in Neuro-Psychopharmacology and Biological Psychiatry 32, 1093-1105.
11. Mandal, P., Pujol, C.A., Carlucci, M.J., Chattopadhyay, K., Damonte, E.B., Ray, B., 2008. Anti-herpetic activity of a sulfated xylomannan from Scinaia hatei. Phytochemistry 69, 2193-2199.
12. Nasra, J., Belvisi, M.G., 2009. Modulation of sensory nerve function and the cough reflex: understanding disease pathogenesis. Pharmacology & Therapeutics 124, 354-375.
13. Nosál'ová, G., Capek, P., Šutovská, M., Fraňová, S., Matulová, M., 2006. Antitussive active polysaccharides from ornamental-medicinal plants. In: Teixeira da Silva, J.A. (Ed.), Floriculture, Ornamental and Plant Biotechnology. , 4th ed. Global Science Books, United Kingdom, pp. 472-481.
14. Schappert, S.M., Burt, C.W., 2006. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001-02. Vital and Health Statistics 13, 1-66.
15. Šutovská, M., Fraňová, S., Prisenžňáková, L., Nosál'ová, G., Togola, A., Diallo, D., Paulsen, B.S., Capek, P., 2009. Antitussive activity of polysaccharides isolated from the Malian medicinal plants. International Journal of Biological Macromolecules 44, 236-239.
16. Ziment, I., 2002. Herbal antitussive. Pulmonary Pharmacology & Therapeutics 15, 324-327.