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Host genes associated with HIV/AIDS: Advances in gene discovery
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This is an excellent review of host genetic studies of HIV/AIDS. In addition to review of the first five GWAS of HIV/AIDS, the review provides an excellent overview of candidate gene studies and identifies areas for future research
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An P, Winkler CA. Host genes associated with HIV/AIDS: advances in gene discovery. Trends Genet.26(3):119-131. This is an excellent review of host genetic studies of HIV/AIDS. In addition to review of the first five GWAS of HIV/AIDS, the review provides an excellent overview of candidate gene studies and identifies areas for future research.
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Trends Genet
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An, P.1
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DOI 10.1038/381661a0
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Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature. 1996;381(6584):667-673. (Pubitemid 26197680)
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Moore, J.P.10
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4
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16044373004
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Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
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Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth RJ, Collman RG, Doms RW, Vassart G, Parmentier M. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 1996;382(6593):722-725.
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Parmentier, M.22
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58149203242
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Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: The ANRS Genome Wide Association 01 study
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Association AGW
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Dalmasso C, Carpentier W, Meyer L, Rouzioux C, Goujard C, Chaix ML, Lambotte O, Avettand-Fenoel V, Le Clerc S, de Senneville LD, Deveau C, Boufassa F, Debre P, Delfraissy JF, Broet P, Theodorou I, Association AGW. Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. PLoS One. 2008;3(12):e3907.
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Common genetic variation and the control of HIV-1 in humans
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Immunology NCfHAV
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Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, De Luca A, Easterbrook P, Gunthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A, Goldstein DB, Immunology NCfHAV. Common genetic variation and the control of HIV-1 in humans. PLoS Genet. 2009;5(12):e1000791.
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Wolinsky, S.M.22
Martinson, J.J.23
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Margolick, J.B.25
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34548134145
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A whole-genome association study of major determinants for host control of HIV-1
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This is the first GWAS of HIV/AIDS. The study demonstrated the feasibility and utility of host genome searches
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Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, De Luca A, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Goldstein DB. A whole-genome association study of major determinants for host control of HIV-1. Science. 2007;317 (5840):944-947. This is the first GWAS of HIV/AIDS. The study demonstrated the feasibility and utility of host genome searches.
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Science
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Fellay, J.1
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Haynes, B.F.25
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Goldstein, D.B.27
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8
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75749117111
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Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS
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Herbeck JT, Gottlieb GS, Winkler CA, Nelson GW, An P, Maust BS, Wong KG, Troyer JL, Goedert JJ, Kessing BD, Detels R, Wolinsky SM, Martinson J, Buchbinder S, Kirk GD, Jacobson LP, Margolick JB, Kaslow RA, O'Brien SJ, Mullins JI. Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS. J Infect Dis. 201(4):618-626.
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J Infect Dis
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Herbeck, J.T.1
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Mullins, J.I.20
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A whole genome association study of mother-to-child transmission of HIV in Malawi
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the NCfHIVAVI.
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Joubert BR, Lange EM, Franceschini N, Mwapasa V, North KE, Meshnick SR, the NCfHIVAVI. A whole genome association study of mother-to-child transmission of HIV in Malawi. Genome Med. 2(3):17.
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Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03)
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Le Clerc S, Limou S, Coulonges C, Carpentier W, Dina C, Taing L, Delaneau O, Labib T, Sladek R, Group AG, Deveau C, Guillemain H, Ratsimandresy R, Montes M, Spadoni JL, Therwath A, Schachter F, Matsuda F, Gut I, Lelievre JD, Levy Y, Froguel P, Delfraissy JF, Hercberg S, Zagury JF. Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). J Infect Dis. 2009;200(8):1194-1201.
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77955970286
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Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS
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This is a GWAS of the LTNP phenotype that identified a novel but mechanistically sound locus for the trait. The refinement of the non-progression phenotype by exclusion of elite controllers highlighted the value of exploring other HIV/AIDS phenotypes and in applying new knowledge to refine phenotypes
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Limou S, Coulonges C, Herbeck JT, van Manen D, An P, Le Clerc S, Delaneau O, Diop G, Taing L, Montes M, van't Wout AB, Gottlieb GS, Therwath A, Rouzioux C, Delfraissy JF, Lelievre JD, Levy Y, Hercberg S, Dina C, Phair J, Donfield S, Goedert JJ, Buchbinder S, Estaquier J, Schachter F, Gut I, Froguel P, Mullins JI, Schuitemaker H, Winkler C, Zagury JF. Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS. J Infect Dis. 202(6):908-915. This is a GWAS of the LTNP phenotype that identified a novel but mechanistically sound locus for the trait. The refinement of the non-progression phenotype by exclusion of elite controllers highlighted the value of exploring other HIV/AIDS phenotypes and in applying new knowledge to refine phenotypes.
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Le Clerc, S.6
Delaneau, O.7
Diop, G.8
Taing, L.9
Montes, M.10
Van't Wout, A.B.11
Gottlieb, G.S.12
Therwath, A.13
Rouzioux, C.14
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Hercberg, S.18
Dina, C.19
Phair, J.20
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Goedert, J.J.22
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Froguel, P.27
Mullins, J.I.28
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58849125366
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Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
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Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, Labib T, Taing L, Sladek R, Deveau C, Ratsimandresy R, Montes M, Spadoni JL, Lelievre JD, Levy Y, Therwath A, Schachter F, Matsuda F, Gut I, Froguel P, Delfraissy JF, Hercberg S, Zagury JF, Group AG. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). J Infect Dis. 2009;199(3):419-426.
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Infectious Disease Clinical Research Program HIVWG, National Institute of A, Infectious Diseases Center for HIVAVI. Host determinants of HIV-1 control in African Americans
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Pelak K, Goldstein DB, Walley NM, Fellay J, Ge D, Shianna KV, Gumbs C, Gao X, Maia JM, Cronin KD, Hussain SK, Carrington M, Michael NL, Weintrob AC, Infectious Disease Clinical Research Program HIVWG, National Institute of A, Infectious Diseases Center for HIVAVI. Host determinants of HIV-1 control in African Americans. J Infect Dis. 201(8):1141-1149.
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Siddiqui RA, Sauermann U, Altmuller J, Fritzer E, Nothnagel M, Dalibor N, Fellay J, Kaup FJ, Stahl-Hennig C, Nurnberg P, Krawczak M, Platzer M. X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. Am J Hum Genet. 2009;85(2):228-239.
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HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles
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Careful modeling resulted in the dissection of these two tightly linked loci and provided evidence of unique contributions of each locus. Of note, the HCP5 locus was associated with progression and not delayed progression, contrary to previous report due to the strong correlation with the protective HLA-B locus
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Catano G, Kulkarni H, He W, Marconi VC, Agan BK, Landrum M, Anderson S, Delmar J, Telles V, Song L, Castiblanco J, Clark RA, Dolan MJ, Ahuja SK. HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles. PLoS One. 2008;3(11):e3636. Careful modeling resulted in the dissection of these two tightly linked loci and provided evidence of unique contributions of each locus. Of note, the HCP5 locus was associated with progression and not delayed progression, contrary to previous report due to the strong correlation with the protective HLA-B locus.
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Establishing a cohort at high risk of HIV infection in South Africa: Challenges and experiences of the CAPRISA 002 acute infection study
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