Effect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytes

Journal of Ethnopharmacology

Volumn 134, Issue 2, 2011, Pages 234-242

  Kim, Joo Hee ^a   Huh, Jeong Eun ^b   Baek, Yong Hyeon ^b   Lee, Jae Dong ^a   Choi, Do Young ^a   Park, Dong Suk ^b  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

Author keywords

Cartilage protection; Inflammatory cytokines; Mitogen activated protein kinase; Osteoarthritis; Phellodendron amurense; Proteolytic enzymes

Indexed keywords

AGGRECANASE 1; AGGRECANASE 2; ALCOHOL; CELECOXIB; COLLAGEN TYPE 2; COLLAGENASE 3; CYTOKINE; GLYCOSAMINOGLYCAN POLYSULFATE; INTERLEUKIN 1ALPHA; INTERSTITIAL COLLAGENASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHELLODENDRON AMURENSE EXTRACT; PROSTAGLANDIN E2; PROTEOGLYCAN; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ARTICLE; ARTICULAR CARTILAGE; BARK; CARTILAGE CELL; CARTILAGE DEGENERATION; CHONDROPROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORK TREE; CULTURE MEDIUM; DOWN REGULATION; DRUG EFFICACY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; OSTEOARTHRITIS; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ADAM PROTEINS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; GLYCOSAMINOGLYCANS; HUMANS; INTERLEUKIN-1ALPHA; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOARTHRITIS; PHELLODENDRON; PHOSPHORYLATION; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; PLANT STEMS; PROCOLLAGEN N-ENDOPEPTIDASE; PYRAZOLES; RNA, MESSENGER; SULFONAMIDES; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

PHELLODENDRON AMURENSE; RUTACEAE;

EID: 79952693612     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.12.005     Document Type: Article

References (39)

1. Akhund, L., Quinet, R.J., Ishaq, S., 2003. Celecoxib-related renal papillary necrosis. Archives of Internal Medicine 163, 114-115. (Pubitemid 36091609)
2. Baker, A.H., Edwards, D.R., Murphy, G., 2002. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. Journal of Cell Science 115, 3719-3727. (Pubitemid 35203598)
3. Bao, Y.X., Wong, C.K., Li, E.K.M., Tam, L.S., Leung, P.C., Yin, Y.B., Lam, C.W.K., 2006. Immunomodulatory effects of Lingzhi and San-Miao-San supplementation on patients with rheumatoid arthritis. Immunopharmacology and Immunotoxicology 29, 197-200.
4. Burrage, P.S., Mix, K.S., Brinckerhoff, C.E., 2006. Matrix metalloproteinases: role in arthritis. Frontiers in Bioscience 11, 529-543. (Pubitemid 43258162)
5. Chang, S.Y., Howden, C.W., 2004. Is no NSAID a good NSAID? Approaches to NSAID-associated upper gastrointestinal disease. Current Gastroenterology Reports 6, 447-453. (Pubitemid 39591824)
6. Cuellar, M.J., Giner, R.M., Recio, M.C., Manez, S., Rios, J.L., 2001. Topical antiinflammatory activity of some Asian medicinal plants used in dermatological disorders. Fitoterapia 72, 221-229. (Pubitemid 32273462)
7. Dieppe, P., Chard, J.A., Faulkner, A., Lohmander, S., 2000. Osteoarthritis. In: Bartons (Ed.), Clinical Evidence. BMJ Publishing Group, London, pp. 649-663.
8. DiMicco, M.A., Patwari, P., Siparsky, P.N., Kumar, S., Pratta, M.A., Lark, M.W., Kim, Y.J., Grodzinsky, A.J., 2004. Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis Rheumatism 50, 840-848. (Pubitemid 38326184)
9. Dvorkin, L., Song, K.Y., 2002. Herbs for benign prostatic hyperplasia. The Annals of Pharmacotherapy 36, 1443-1452. (Pubitemid 34925282)
10. Faour, W.H., He, A., Mancini, Q., Jovanovic, D., Antoniou, J., Di Battista, J.A., 2006. Prostaglandin E2 stimulates p53 transactivational activitiy through specific serine 15 phosphorylation in human synovial fibroblasts. Role in suppression of c/EBP/NF-kappaB-mediated MEKK1-induced MMP-1 expression. Journal of Biological Chemistry 281, 19849-19860. (Pubitemid 44081199)
11. Farkouh, M.E., Greenberg, J.D., Jeger, R.V., Ramanathan, K., Verheugt, F.W., Chesebro, J.H., Kirshner, H., Hochman, J.S., Lay, C.L., Ruland, S., Mellein, B., Matchaba, P.T., Fuster, V., Abramson, S.B., 2007. Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib. Annals of the Rheumtic Disease 66, 764-770. (Pubitemid 46846695)
12. Felson, D.T., 2006. Clinical practice. Osteoarthritis of the Knee. New England Journal of Medicine 354, 841-848.
13. Hardy, M.M., Seibert, K., Manning, P.T., Currie, M.G., Woerner, B.M., Edwards, D., 2002. Cyclooxygenase2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants. Arthritis Rheumatism 46, 1789-1803. (Pubitemid 34774511)
14. Huh, J., 1999. 1613 AD. In: Dong Ui Bo Gam [The precious mirror of oriental medicine], Namsandang, Seoul.
15. Iannone, F., Lapadula, G., 2003. The pathophysiology of osteoarthritis. Aging Clinical Experimental Research 15, 364-372. (Pubitemid 37509161)
16. Ishikawa, T., Nishigaki, F., Miyata, S., Hirayama, Y., Minoura, K., Imanishi, J., Neya, M., Mizutani, T., Imamura, Y., Naritomi, Y., Murai, H., Ohkubo, Y., Kagayama, A., Mutoh, S., 2005. Prevention of progressive joint destruction in type II collagen-treated arthritis in rats by a novel matrix metalloproteinase inhibitor. British Journal of Pharmacology 144, 133-143. (Pubitemid 40188555)
17. Kim, H.C., 2000. Herbalogy. Young Lim Sa, Seoul.
18. Kumar, A.P., Bhaskaran, S., Ganapathy, M., Crosby, K., Davis, M.D., Kochunov, P., Schoolfield, J., Yeh, I.T., Troyer, D.A., Ghosh, R., 2007. Akt/CREB/Cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate (TRAMP) model mediated by Nexrutine, a Phellodendron amurense bark extract. Clinical Cancer Research 13, 2784-2794. (Pubitemid 46788048)
19. Laufers, S., 2004. Osteoarthritis therapy - are there still unmet needs. Rheumatology 43, i9-i15.
20. Li, S., Lu, A.P., Wang, Y.Y., Li, Y.D., 2003. Suppressive effects of a Chinese herbal medicine Qing-Luo-Yin extract on the angiogenesis of type II collagen-treated arthritis in rats. American Journal of Chinese Medicine 31, 713-720. (Pubitemid 41758795)
21. Majumdar, M.K., Askew, R., Schelling, S., Stedman, N., Blanchet, T., Hopkins, B., Morris, E.A., Glasson, S.S., 2007. Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. Arthritis Rheumatism 56, 3670-3674. (Pubitemid 350100701)
22. Marcus, D.M., Grollman, A.P., 2002. Botanical medicines - the need for new regulations. New England Journal of Medicine 347, 2073-2076. (Pubitemid 35461667)
23. Mengshol, J.A., Mix, K.S., BrinckerhoV, C.E., 2002. Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark? Arthritis Rheumatism 46, 13-20.
24. Nagase, H., Kashiwagi, M., 2003. Aggrecanases and cartilage matrix degradation. Arthritis Research Therapy 5, 94-103. (Pubitemid 36849755)
25. Neuhold, L.A., killer, L., Zhao, W., Sung, M.L., Warner, L., Kulik, J., Turner, J., Wu, W., Billinghurst, C., Meijers, T., Poole, A.R., Babij, P., DeGennaro, L.J., 2001. Postnatal expression in hyaline cartilage of constitutively active human type II collagenase-3 (MMP-13) induces osteoarthritis in mice. Journal of Clinical Investigation 107, 35-44.
26. Oben, J., Enonchong, E., Kothari, S., Chambliss, W., Garrison, R., Dolnick, D., 2009. Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study. Nutrition Journal 8, 38.
27. Panico, A.M., Vicini, P., Massimo, G., Cardile, V., Gentile, B., Avondo, S., Vittorio, F., Ronsisvalle, G., 2004. Protective effects of benzisothiazolylamidines on IL-1 beta induced alterations in human articular chondrocyte metabolism. Inflammation 28, 231-235. (Pubitemid 41449423)
28. Park, E.K., Rhee, H.I., Jung, H.S., Ju, S.M., Lee, Y.A., Lee, S.H., Hong, S.J., Yang, H.I., Yoo, M.C., Kim, K.S., 2007. Antiinflammatory effects of a combined herbal preparation (RAH13) of Phellodendron amurense and Coptis chinensis in animal models of inflammation. Phytotherapy Research 21, 746-750. (Pubitemid 47217774)
29. Park, J.I., Shim, J.K., Do, J.W., Do, J.W., Kim, S.Y., Seo, E.K., Kwon, H.J., Lee, T.K., Kim, J.K., Choi, D.Y., Kim, C.H., 1999. Immune-stimulating properties of polysaccharides from Phellodendri cortex (Hwangbek). Glycoconjugate Journal 16, 247-252.
30. Patwari, P., Cheng, D.M., Cole, A.A., Kuettner, K.E., Grodzinsky, A.J., 2007. Analysis and of the relationship between peak stress and proteoglycan loss following injurious compression ofhumanpost-mortem knee and ankle cartilage. Biomechanics Modeling in Mechanobiology 6, 83-89. (Pubitemid 44893163)
31. Piecha, D., Weik, J., Kheil, H., Becher, G., Timmermann, A., Jaworski, A., Burger, M., Hofmann, M.W., 2010. Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants. Inflammation Research 59, 379-389.
32. Poole, A.R., 2000. Cartilage in health and disease. In: Koopman, W.J. (Ed.), Arthritis and Allied Conditions: A Textbook of Rheumatology. , 14th ed. Lippincott Williams &Wilkins, Philadelphia, pp. 226-284.
33. Powell, A.J., Little, C.B., Hughes, C.E., 2007. Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system. Arthritis Rheumatism 56, 3010-3019. (Pubitemid 47502748)
34. Sabatini, M., Lesur, C., Thomas, M., Chomel, A., Anract, P., de Nanteuil, G., Pastoureau, P., 2005. Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis. Arthritis Rheumtism 52, 171-180. (Pubitemid 40129246)
35. Sondergaard, B.C., Schultz, N., Madsen, S.H., Bay-Jensen, A.C., Kassem, M., Karsdal, M.A., 2010. MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation-divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Osteoarthritis Cartilage 18, 279-288.
36. Tapsell, L.C., Hemphill, I., Cobiac, L., Patch, C.S., Sullivan, D.R., Fenech, M., Roodenrys, S., Keogh, J.B., Clifton, P.M., Williams, P.G., Fazio, V.A., Inge, K.E., 2006. Health benefits of herbs and spices: the past, the present, the future. Medical Journal of Australia 185, S4-S24.
37. Tortorella, M.D., MAlfait, A.M., Deccico, C., Arner, E., 2001. The role of ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2) in model of cartilage degradation. Osteoarthritis Cartilage 9, 539-552. (Pubitemid 32842633)
38. Vincenti, M.P., Brinckerho, V.C.E., 2002. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-speciWc transcription factors. Arthritis Research 4, 157-164. (Pubitemid 34460754)
39. Xu, Y., Ventura, S., 2010. Extracts of bark from the traditional Chinese herb Phellodendron amurense inhibit contractility of the isolated rat prostate gland. Journal of Ethnopharmacology 127, 196-199.