Effect of captopril on TNF-α and IL-10 in the livers of bile duct ligated rats

Iranian Journal of Immunology

Volumn 7, Issue 4, 2010, Pages 247-251

  Amirshahrokhi, Keyvan ^a,b   Ghazi Khansari, Mahmoud ^a   Mohammadi Farani, Ahmad ^a,c   Karimian, Golnar ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ARDABIL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Captopril; Hepatic fibrosis; IL 10; TNF

Indexed keywords

CAPTOPRIL; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; LIVER; LIVER FIBROSIS; LIVER PROTECTION; MALE; NONHUMAN; PROTEIN ANALYSIS; RAT;

EID: 79952656755     PISSN: 17351383     EISSN: 1735367X     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Yang L, Bataller R, Dulyx J, Coffman TM, Ginés P, Rippe RA, et al. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol. 2005; 43:317-23.
2. Zhang LJ, Yu JP, Li D, Huang YH, Chen ZX, Wang XZ. Effects of cytokines on carbon tetrachloride-induced hepatic fibrogenesis in rats. World J Gastroenterol. 2004; 10:77-81.
3. Schindler R, Dinarello CA, Koch KM. Angiotensin-converting-enzyme inhibitors suppress synthesis of tumour necrosis factor and interleukin 1 by human peripheral blood mononuclear cells. Cytokine. 1995; 7:526-33.
4. Zhang X, Li ZZ, Liu DF, Xu X, Mei ZC, Shen W. Angiotensin-converting enzyme inhibitors improve hepatic steatosis by modulating expression of tumour necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 in rats with type 2 diabetes. Clin Exp Pharmacol Physiol. 2009; 36:631-6.
5. Muriel P. NF-kappaB in liver diseases: a target for drug therapy. J Appl Toxicol. 2009; 29:91-100.
6. Wang XZ, Zhang LJ, Li D, Huang YH, Chen ZX, Li B. Effects of transmitters and interleukin-10 on rat hepatic fibrosis induced by CCl4. World J Gastroenterol. 2003; 9:539-43.
7. Wei YH, Jun L, Qiang CJ. Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats. Dig Dis Sci. 2004; 49:1589-94.
8. Karimian G, Mohammadi-Karakani A, Sotoudeh M, Ghazi-Khansari M, Ghobadi G, Shakiba B. Attenuation of hepatic fibrosis through captopril and enalapril in the livers of bile duct ligated rats. Biomed Pharmacother. 2008; 62:312-6.
9. Amirshahrokhi K, Dehpour AR, Hadjati J, Sotoudeh M, Ghazi-Khansari M. Methadone ameliorates multiple-low-dose streptozotocin-induced type 1 diabetes in mice. Toxicol Appl Pharmacol. 2008; 232:119-24.
10. Kim MY, Baik SK, Park DH, Jang YO, Suk KT, Yea CJ, et al. Angiotensin receptor blockers are superior to angiotensinconverting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model. J Gastroenterol. 2008; 43:889-96.
11. Toblli JE, Muñoz MC, Cao G, Mella J, Pereyra L, Mastai R. ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats. Obesity(Silver Spring). 2008; 16:770-6.
12. Fernández-Martínez E, Pérez-Alvarez V, Tsutsumi V, Shibayama M, Muriel P. Chronic bile duct obstruction induces changes in plasma and hepatic levels of cytokines and nitric oxide in the rat. Exp Toxicol Pathol. 2006; 58:49-58.
13. Peeters AC, Netea MG, Kullberg BJ, Thien T, van der Meer JW. The effect of renin-angiotensin system inhibitors on proand anti-inflammatory cytokine production. Immunology. 1998; 94:376-9.
14. Zagariya A, Bhat R, Navale S, Chari G, Vidyasagar D. Inhibition of meconium-induced cytokine expression and cell apoptosis by pretreatment with captopril. Pediatrics. 2006; 117:1722-7.
15. Breitkopf K, Haas S, Wiercinska E, Singer MV, Dooley S. Anti-TGF-beta strategies for the treatment of chronic liver disease. Alcohol Clin Exp Res. 2005; 29:121S-131S.
16. Dinant S, Veteläinen RL, Florquin S, van Vliet AK, van Gulik TM. IL-10 attenuates hepatic I/R injury and promotes hepatocyte proliferation. J Surg Res. 2007; 141:176-82.
17. Albuquerque D, Nihei J, Cardillo F, Singh R. The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4 (+) CD103 (+) CD25 (negative) splenic T cell numbers. Cell Immunol. 2010; 260:92-7.