Modelling the blood-brain barrier

Neuromethods

Volumn 56, Issue , 2011, Pages 145-160

  Dehouck, Marie Pierre ^a,b   Vandenhaute, Elodie ^a,b   Dehouck, Lucie ^a,b   Sevin, Emmanuel ^a,b   Lenfant, Anne Marie ^a,b   Delplace, Yannick ^a,b   Hallier Vanuxeem, Dorothée ^a,b   Culot, Maxime ^a,b   Cecchelli, Roméo ^a,b  

^a UNIV LILLE   (France)

^b UNIVERSITÉ D'ARTOIS   (France)

Author keywords

Blood brain barrier; Cell culture; Endothelial cells; Glial cells; In vitro models; Permeability

Indexed keywords

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CELL ISOLATION; COCULTURE; CULTURE MEDIUM; CULTURE OPTIMIZATION; CULTURE TECHNIQUE; ENDOTHELIUM CELL; GLIA CELL; HUMAN; IN VITRO STUDY; MEMBRANE BIOLOGY; MEMBRANE PERMEABILITY; MICROVASCULATURE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NEUROBIOLOGY; NONHUMAN; PRIORITY JOURNAL;

BOVINAE; RATTUS;

EID: 79952613193     PISSN: 08932336     EISSN: 19406045     Source Type: Book Series    
DOI: 10.1007/978-1-61779-077-5_7     Document Type: Article

References (16)

1. Dehouck MP, Meresse S, Delorme P, Fruchart JC, Cecchelli R (1990) An easier reproducible, and mass-production method to study the blood-brain barrier in vitro. J Neurochem 54:1798-1801
2. Mertsch K, Maas J (2002) Blood-brain barrier penetration and drug development from an industrial point of view. Curr Med Chem 2:187
3. Cecchelli R, Berezowski V, Lundquist S, Culot M, Renftel M, Dehouck MP, Fenart L (2007) Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov 6:650-661 (Pubitemid 47202487)
4. Brillault J, Berezowski V, Cecchelli R, Dehouck MP (2002) Intercommunications between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood-brain barrier during ischaemia. J Neurochem 83:807-817 (Pubitemid 35316030)
5. Culot M, Mysiorek C, Renftel M, Roussel BD, Hommet Y, Vivien D, Cecchelli R, Fenart L, Berezowski V, Dehouck MP, Lundquist S (2009) Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study. Brain Res 1294:144-152
6. Coisne C, Dehouck L, Faveeuw C, Delplace Y, Miller F, Landry C, Morissette C, Fenart L, Cecchelli R, Tremblay P, Dehouck B (2005) Mouse syngenic in vitro blood-brain barrier model: A new tool to examine inflammatory events in cerebral endothelium. Lab Invest 85:734-746 (Pubitemid 40799703)
7. Mysiorek C, Culot M, Dehouck L, Derudas B, Staels B, Bordet R, Cecchelli R, Fenart L, Berezowski V (2009) Peroxisome-proliferatoractivated receptor-alpha activation protects brain capillary endothelial cells from oxygenglucose deprivation-induced hyperpermeability in the blood-brain barrier. Curr Neurovasc Res 6:181-193
8. Gennari A, van den Berghe C, Casati S, Castell J, Clemedson C, Coecke S, Colombo A, Curren R, Dal Negro G, Goldberg A, Gosmore C, Hartung T, Langezaal I, Lessigiarska I, Maas W, Mangelsdorf I, Parchment R, Prieto P, Sintes JR, Ryan M, Schmuck G, Stitzel K, Stokes W, Vericat JA, Gribaldo L (2004) Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50. Altern Lab Anim 32:437-459 (Pubitemid 40139222)
9. Hallier-Vanuxeem D, Prieto P, Culot M, Diallo H, Landry C, Tahti H, Cecchelli R (2009) New strategy for alerting central nervous system toxicity: Integration of blood- brain barrier toxicity and permeability in neurotoxicity assessment. Toxicol In Vitro 23:447-453
10. Cecchelli R, Dehouck B, Descamps L, Fenart L, Buee-Scherrer VV, Duhem C, Lundquist S, Rentfel M, Torpier G, Dehouck MP (1999) In vitro model for evaluating drug transport across the blood-brain barrier. Adv Drug Deliv Rev 36:165-178 (Pubitemid 29121970)
11. Dehouck B, Dehouck MP, Fruchart JC, Cecchelli R (1994) Upregulation of the low density lipoprotein receptor at the blood- brain barrier: Intercommunications between brain capillary endothelial cells and astrocytes. J Cell Biol 126:465-473 (Pubitemid 24226262)
12. Prieto P, Blaauboer BJ, de Boer AG, Boveri M, Cecchelli R, Clemedson C, Coecke S, Forsby A, Galla HJ, Garberg P, Greenwood J, Price A, Tahti H (2004) Blood-brain barrier in vitro models and their application in toxicology. The report and recommendations of ECVAM Workshop 49. Altern Lab Anim 32:37-50 (Pubitemid 38524900)
13. Boveri M, Berezowski V, Price A, Slupek S, Lenfant AM, Benaud C, Hartung T, Cecchelli R, Prieto P, Dehouck MP (2005) Induction of blood-brain barrier properties in cultured brain capillary endothelial cells: Comparison between primary glial cells and C6 cell line. Glia 51:187-198 (Pubitemid 41297425)
14. Booher J, Sensenbrenner M (1972) Growth and cultivation of dissociated neurons and glial cells from embryonic chickrat and human brain in flask cultures. Neurobiology 2:97-105
15. Siflinger-Birnboim A, Del Vecchio PJ, Cooper JA, Blumenstock FA, Shepard JM, Malik AB (1987) Molecular sieving characteristics of the cultured endothelial monolayer. J Cell Physiol 132:111-117 (Pubitemid 17105330)
16. Meresse S, Dehouck MP, Delorme P, Bensaid M, Tauber JP, Delbart C, Fruchart JC, Cecchelli R (1989) Bovine brain endothelial cells express tight junctions and monoamine oxidase activity in long-term culture. J Neurochem 53:1363-1371 (Pubitemid 19267001)