Reply to Quistorff and Grunnet: Dysfunctional mitochondria, brain lactate, and lactate dehydrogenase isoforms

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 7, 2011, Pages

  Ross, Jaime M ^a,b   Coppotelli, Giuseppe ^a   Olson, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; ISOENZYME; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE ISOENZYME 1; LACTATE DEHYDROGENASE ISOENZYME 5; LACTIC ACID; MITOCHONDRIAL DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVIC ACID; SUCCINATE DEHYDROGENASE; UNCLASSIFIED DRUG;

AGING; ASTROCYTE; CATALYSIS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE MUTATION; LETTER; NERVE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 79952605988     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1018791108     Document Type: Letter

References (5)

1. Quistorff B, Grunnet N (2011) High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio. Proc Natl Acad Sci USA 108:E21.
2. Ross JM, et al. (2010) High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio. Proc Natl Acad Sci USA 107:20087-20092.
3. Trifunovic A, et al. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417-423. (Pubitemid 38715133)
4. Schurr A (2006) Lactate: The ultimate cerebral oxidative energy substrate? J Cereb Blood Flow Metab 26:142-152.
5. Downer JD, Sevinsky JR, Ahn NG, Resing KA, Betterton MD (2006) Incorporating expression data in metabolic modeling: A case study of lactate dehydrogenase. J Theor Biol 240:464-474.