Reduced 13C-d-xylose absorption in alcoholics is more likely caused by alterations in small intestinal mucosa than delayed gastric emptying

Scandinavian Journal of Gastroenterology

Volumn 46, Issue 4, 2011, Pages 414-419

  Hope, Haavar Blich ^a   Medhus, Asle Wilhelm ^b   Sandstad, Olav ^b   Borge, Christine Raaheim ^a   Skar, Viggo ^a  

^a LOVISENBERG DIAKONALE HOSPITAL   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

13C D xylose breath test; 13C octanoic acid breath test; alcoholics; gastric emptying; malabsorption syndromes

Indexed keywords

CARBON DIOXIDE; DEXTRO XYLOSE C 13; MARGARINE; OCTANOIC ACID C 13; UNCLASSIFIED DRUG; WATER; XYLOSE; ALCOHOL; OCTANOIC ACID; OCTANOIC ACID DERIVATIVE;

ADULT; AGED; ALCOHOLISM; ARTICLE; BREAD; BREATH ANALYSIS; CARBON DIOXIDE MEASUREMENT; CLINICAL ARTICLE; CONTROLLED STUDY; EGG; EXPIRED AIR; FALSE POSITIVE RESULT; FEMALE; HUMAN; MALABSORPTION; MALE; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; SMALL INTESTINE ABSORPTION; SMALL INTESTINE MUCOSA; STOMACH EMPTYING; TEST MEAL; TIME TO MAXIMUM PLASMA CONCENTRATION; XYLOSE TEST; INTESTINE ABSORPTION; INTESTINE MUCOSA; LABORATORY DIAGNOSIS; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; SMALL INTESTINE;

ADULT; AGED; ALCOHOLISM; BREATH TESTS; CARBON DIOXIDE; ETHANOL; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; MALABSORPTION SYNDROMES; MALE; MIDDLE AGED; OCTANOIC ACIDS; XYLOSE; YOUNG ADULT;

EID: 79952605879     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2010.536252     Document Type: Article

References (24)

1. Bode C, Bode JC. Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol 2003;17:575-92.
2. Hope HB, Tveito K, Aase S, Messelt E, Utzon P, Skar V. Small intestinal malabsorption in chronic alcoholism determined by 13C-D-xylose breath test and microscopic examination of the duodenal mucosa. Scand J Gastroenterol 2010; 45:39-45.
3. Hope HB, Tveito K, Aase S, Messelt E, Utzon P, Skar V. Erratum: Small intestinal malabsorption in chronic alcoholism determined by 13C-D-xylose breath test and microscopic examination of the duodenal mucosa. Scand J Gastroenterol 2010;45(12):1519.
4. Inamori M, Iida H, Endo H, Hosono K, Akiyama T, Yoneda K, et al. Aperitif effects on gastric emptying: a crossover study using continuous real-time 13C breath test (BreathID System). Dig Dis Sci 2009;54:816-18.
5. Franke A, Nakchbandi IA, Schneider A, Harder H, Singer MV. The effect of ethanol and alcoholic beverages on gastric emptying of solid meals in humans. Alcohol Alcohol 2005;40:187-93.
6. Jian R, Cortot A, Ducrot F, Jobin G, Chayvialle JA, Modigliani R. Effect of ethanol ingestion on postprandial gastric emptying and secretion, biliopancreatic secretions, and duodenal absorption inman.Dig Dis Sci 1986;31:604-14.
7. Mushambi MC, Bailey SM, Trotter TN, Chadd GD, Rowbotham DJ. Effect of alcohol on gastric emptying in volunteers. Br J Anaesth 1993;71:674-6.
8. Pfaffenbach B, Adamek RJ, Hagemann D, Schaffstein J, Wegener Ml. Gastric emptying and antral myoelectrical activity in chronic alcoholics with dyspepsia. Hepatogastroenterology 1998;45:1165-71.
9. WegenerM, Schaffstein J, Dilger U, Coenen C, Wedmann B, Schmidt G. Gastrointestinal transit of solid-liquid meal in chronic alcoholics. Dig Dis Sci 1991;36:917-23.
10. Chang CS, Chen GH, Kao CH, Wang SJ, Peng SN, Huang CK, et al. Increased accuracy of the carbon-14 Dxylose breath test in detecting small-intestinal bacterial overgrowth by correction with the gastric emptying rate. Eur J Nucl Med 1995;22:1118-22.
11. Burge MR, Tuttle MS, Violett JL, Stephenson CL, Schade DS. Potato-lactulose breath hydrogen testing as a function of gastric motility in diabetes mellitus. Diabetes Technol Ther 2000;2:241-8.
12. Lieber CS. To drink (moderately) or not to drink? N Engl J Med 1984;310:846-8.
13. Tveito K, Brunborg C, Sandvik L, Loeberg EM, Skar V. (13)C-xylose and (14)C-xylose breath tests for the diagnosis of coeliac disease. Scand J Gastroenterol 2008;43: 166-73.
14. Dean RB, Dixon WJ. Simplified statistics for small numbers of observations. Anal Chem 1951;23:636-8.
15. Maes BD, Ghoos YF, Rutgeerts PJ, Hiele MI, Geypens B, Vantrappen G. [*C]octanoic acid breath test to measure gastric emptying rate of solids. Dig Dis Sci 1994;39 (12 Suppl):104S-6S.
16. Schoeller DA, Klein PD, MacLean Jr WC, Watkins JB, Van Santen E. Fecal 13C analysis for the detection and quantitation of intestinal malabsorption. Limits of detection and application to disorders of intestinal cholylglycine metabolism. J Lab Clin Med 1981;97: 440-8.
17. Haycock GB, Schwartz GJ, Wisotsky DH. Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J Pediatr 1978;93:62-6.
18. Hellmig S, Von SF, Gadow C, Katsoulis S, Hedderich J, Fölsch UR, et al. Gastric emptying time of fluids and solids in healthy subjects determined by 13C breath tests: influence of age, sex and body mass index. J Gastroenterol Hepatol 2006; 21:1832-8.
19. Kendall MJ, Nutter S. The influence of sex, body weight, and renal function on the xylose test. Gut 1970;11:1020-3.
20. Thompson DG, Wingate DL, Thomas M, Harrison D. Gastric emptying as a determinant of the oral glucose tolerance test. Gastroenterology 1982;82:51-5.
21. Sarin SK, Dhingra N, Bansal A, Malhotra S, Guptan RC. Dietary and nutritional abnormalities in alcoholic liver disease: a comparison with chronic alcoholics without liver disease. Am J Gastroenterol 1997;92:777-83.
22. Mezey E. Intestinal function in chronic alcoholism. Ann N Y Acad Sci 1975;252:215-27.
23. Reddy V, Mammi MV. Intestinal function in malnourished children. J Trop Pediatr Environ Child Health 1976;22:3-4.
24. Ott M, Wegner A, Caspary WF, Lembcke B. Intestinal absorption and malnutrition in patients with the acquired immunodeficiency syndrome (AIDS). Z Gastroenterol 1993; 31:661-5.