A randomized trial of the effectiveness and efficiency of interventions to reduce potential drug interactions in primary care

American Journal of Medical Quality

Volumn 26, Issue 2, 2011, Pages 145-153

  Lopez Picazo, Julio J ^a   Ruiz, Juan C ^a   Sanchez, Jose F ^a   Ariza, Angeles ^a   Aguilera, Belen ^a  

^a Murcia Health Service   (Spain)

Author keywords

drug interaction; drug use; primary care; quality management

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CLINICAL PRACTICE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DRUG INTERACTION; ECONOMICS; EDUCATION; ELECTRONIC PRESCRIBING; FEMALE; GENERAL PRACTICE; HUMAN; INTENTION TO TREAT ANALYSIS; MALE; MEDICAL EDUCATION; MEDICATION ERROR; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SPAIN; TOTAL QUALITY MANAGEMENT;

ADOLESCENT; ADULT; COST-BENEFIT ANALYSIS; DRUG INTERACTIONS; EDUCATION, MEDICAL, CONTINUING; ELECTRONIC PRESCRIBING; FAMILY PRACTICE; FEMALE; HUMANS; INTENTION TO TREAT ANALYSIS; MALE; MEDICATION ERRORS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHYSICIAN'S PRACTICE PATTERNS; SINGLE-BLIND METHOD; SPAIN; TOTAL QUALITY MANAGEMENT;

EID: 79952577298     PISSN: 10628606     EISSN: 1555824X     Source Type: Journal    
DOI: 10.1177/1062860610380898     Document Type: Article

References (29)

1. Jacobson L., Elwyn G., Robling M., Tudor-Jones R. Error and safety in primary care: no clear boundaries. Fam Pract. 2003;20:237-241.
2. Sandars J., Esmail A. The frequency and nature of medical error in primary care: understanding the diversity across studies. Fam Pract. 2003;20:231-236.
3. Kohn LT, Corrigan J., Donaldson MS To Err Is Human: Building a Safer Health System. Washington, DC: National Academies Press; 2000.
4. Moskowitz EJ, Nash DB The quality and safety of ambulatory medical care: current and future prospects. Am J Med Qual. 2007;22:274-288.
5. Woods DM, Thomas EJ, Holl JL, Weiss KB, Brennan TA Ambulatory care adverse events and preventable adverse events leading to a hospital admission. Qual Saf Health Care. 2007;16:127-131.
6. Johnell K., Klarin I. The relationship between number of drugs and potential drug-drug interactions in the elderly: a study of over 600,000 elderly patients from the Swedish Prescribed Drug Register. Drug Saf. 2007;30:911-918.
7. Tulner L., Frankfort S., Gijsen G., Van Campen J., Koks C., Beinjnen J. Drug-drug interactions in a geriatric outpatient cohort: prevalence and relevance. Drugs Aging. 2008;25: 343-355.
8. Gagne JJ, Maio V., Ravinowitz C. Prevalence and predictor of potential drug-drug interactions in Regione Emilia-Romagna, Italy. J Clin Pharm Ther. 2008;33:141-151.
9. APEAS Study: Estudio Sobre la Seguridad de los Pacientes en Atención Primaria de Salud. Madrid, Spain: Ministerio de Sanidad y Consumo; 2008.
10. Lopez-Picazo JJ, Ruiz JC, Sanchez JF,et al.Prevalence and typology of potential drug interactions occurring in primary care patients. Eur J Gen Pract. In press.
11. LeGrand A., Hogerzeil HV, Haaijer-Ruskamp FM Intervention research in rational use of drugs: a review. Health Policy Plan. 1999;14:89-102.
12. Lu CY, Ross-Degnan D., Soumerai SB, Pearson SA Interventions designed to improve the quality and efficiency of medication use in managed care: a critical review of the literature: 2001-2009. BMC Health Serv Res. 2008;8:75.
13. General Council of the Spanish Official College of Pharmacists. Spanish Official College of Pharmacists medications database (BOT). http://www.portalfarma.com/home.nsf. Accessed June 30, 2007.
14. López-Picazo JJ, Barragán A., Bravo G. Cartera de Servicios de Atención Primaria 2003-2004 del Servicio Murciano de Salud. Murcia, Spain: Consejería de Sanidad de la Región de Murcia; 2003.
15. Van der Sijs H., Aarts J., Vulto A., Berg M. Overriding of drug safety alerts in computerized physician order entry. J Am Med Inform Assoc. 2006;13:138-147.
16. Shah NR, Seger AC, Seger DL,et al.Improving acceptance of computerized prescribing alerts in ambulatory care. J Am Med Inform Assoc. 2006;13:5-11.
17. Spina JR, Glassman PA, Belperio P., Cader R., Asch S. Clinical relevance of automated drug alerts from the perspective of medical providers. Am J Med Qual. 2005;20:7-14.
18. Glassman PA, Simon B., Belperio P., Lanto A. Improving recognition of drug interactions: benefits and barriers to using automated drug alerts. Med Care. 2002;40: 1161-1171.
19. Magnus D., Rodgers S., Avery AJ GPs' views on computerized drug interaction alerts: questionnaire survey. J Clin Pharm Ther. 2002;27:377-382.
20. Hsieh TC, Kuperman GJ, Jaggi T.,et al.Characteristics and consequences of drug allergy alert overrides in a computerized physician order entry system. J Am Med Inform Assoc. 2004;11:482-491.
21. Bedell SE, Jabbour S., Goldberg R.,et al.Discrepancies in the use of medications: their extent and predictors in an outpatient patient. Arch Intern Med. 2000;160:2129-2134.
22. Bjerrun L., González B., Petersen G. Risk factor for potential drug interactions in general practice. Eur J Gen Pract. 2008;14:23-29.
23. Tamblyn R., Huang A., Taylor L.,et al.A randomized trial of the effectiveness of on-demand versus computer-triggered drug decision support in primary care. J Am Med Inform Assoc. 2008;15:430-438.
24. Rodríguez-Terol A., Caraballo MO, Palma D. Calidad estructural de las bases de datos de interacciones. Farm Hosp. 2009;33:134-146.
25. Taylor R., Tamblyn R. Reasons for physician non-adherence to electronic drug alerts. Stud Health Technol Inform. 2004; 107(pt 2):1101-1105.
26. Grizzle AJ, Mahmood M., Ko Y.,et al.Reasons provided by prescribers when overriding drug-drug interaction alerts. Am J Manag Care. 2007;13:573-580.
27. Thomson O'Brien MA, Oxman AD, Davis DA, Haynes RB, Freemantle N., Harvey EL Audit and feedback: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2000;(2):CD000259.
28. O'Connell DL, Henry D., Tomlins R. Randomised controlled trial of effect of feedback on general practitioners' prescribing in Australia. BMJ. 1999;318:507-511.
29. Watkins C., Timm A., Gooberman-Hill R., Harvey I., Haines A., Donovan J. Factors affecting feasibility and acceptability of a practice-based educational intervention to support evidence-based prescribing: a qualitative study. Fam Pract. 2004;21:661-669.