A convenient synthesis of the side chain of loteprednol etabonate - An ocular soft corticosteroid from 20-oxopregnanes using metal-mediated halogenation as a key reaction

Steroids

Volumn 76, Issue 5, 2011, Pages 497-501

  Chowdhury, Pritish ^a   Borah, Juri Moni ^a   Goswami, Papori ^a,b   Das, Archana Moni ^a  

^a Natural Products Chemistry Division   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY GUWAHATI   (India)

Author keywords

16 DPA; Anti inflammatory agents; Loteprednol etabonate; Metal mediated halogenation; Soft corticosteroid

Indexed keywords

17ALPHA,21 DICHLORO 3BETA ACETOXY 5ALPHA PREGNAN 20 ONE; 20 EXOPREGNANE DERIVATIVE; 3BETA ACETOXY 5ALPHA PREGNAN 20 ONE 3; 3BETA,21 DIACETOXY 17ALPHA,20ALPHA EPOXY 5ALPHA PREGNANE; 3BETA,21 DIACETOXY 17BETA,20BETA EPOXY 5ALPHA PREGNANE; 3BETA,21 DIACETOXY 5ALPHA PREGNAN 17ALPHA OL 20 ONE; 3BETA,21 DIACETOXY 5ALPHA PREGNAN 17ALPHA,20 DIOL; 3BETA,21 DIACETOXYPREGN 17(20) ENE; 5ALPHA PREGNAN 3BETA,17ALPHA,21 TRIOL 20 ONE; CORTICOSTEROID; LOTEPREDNOL ETABONATE; PREGN 17(20) ENE 3BETA OL 21 OIC ACID METHYL ESTER; PREGN 17(20) ENE 3BETA,21 DIOL; PREGNANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG HYDROXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; FAVORSKII REARRANGEMENT; HALOGENATION; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE;

ADRENAL CORTEX HORMONES; ANDROSTADIENES; ANTI-ALLERGIC AGENTS; HALOGENATION; METALS; OPTICAL DEVICES; PREGNANES;

EID: 79952575530     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.01.006     Document Type: Article

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