Changes in bone mineral density and body composition in children with central precocious puberty and early puberty before and after one year of treatment with GnRH agonist

Hormone Research in Paediatrics

Volumn 75, Issue 3, 2011, Pages 174-179

  Ko, Jung Hee ^a   Lee, Hyo Sung ^a   Lim, Jung Sub ^b   Kim, Shin Mi ^a   Hwang, Jin Soon ^a  

^a Ajou University School of Medicine   (South Korea)

^b Korea Cancer Center Hospital   (South Korea)

Author keywords

Body composition, children; Body mass index; Bone mineral density; Central precocious puberty; Dual energy X ray absorptiometry; GnRH agonist treatment; Obesity; Percent body fat

Indexed keywords

GONADORELIN AGONIST; LEUPRORELIN;

ADOLESCENT; ARTICLE; BODY COMPOSITION; BODY FAT; BONE AGE; BONE DENSITY; BONE MASS; CHILD; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HUMAN; HYPOPHYSIS GONAD SYSTEM; KOREA; MAJOR CLINICAL STUDY; OBESITY; PRECOCIOUS PUBERTY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TREATMENT DURATION;

ABSORPTIOMETRY, PHOTON; ADIPOSITY; AGE DETERMINATION BY SKELETON; AGING; BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; BONE RESORPTION; CHILD; CHILD, PRESCHOOL; FEMALE; GONADOTROPIN-RELEASING HORMONE; HUMANS; MEDICAL RECORDS; OBESITY; PREVALENCE; PUBERTY, PRECOCIOUS; REPUBLIC OF KOREA; RETROSPECTIVE STUDIES;

EID: 79952573577     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000320039     Document Type: Article

References (35)

1. Carel JC, Leger J: Clinical practice. Precocious puberty. N Engl J Med 2008;358:2366-2377.
2. Lee MM: Is treatment with a luteinizing hormone-releasing hormone agonist justified in short adolescents? N Engl J Med 2003;348:942-945.
3. Heger S, Partsch CJ, Sippell WG: Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J Clin Endocrinol Metab 1999;84:4583-4590.
4. Kamp GA, Manasco PK, Barnes KM, Jones J, Rose SR, Hill SC, Cutler GB Jr: Low growth hormone levels are related to increased body mass index and do not reflect impaired growth in luteinizing hormone-releasing hormone agonist-treated children with precocious puberty. J Clin Endocrinol Metab 1991;72:301-307. (Pubitemid 21921692)
5. Van der Sluis IM, Boot AM, Krenning EP, Drop SL, de Muinck Keizer-Schrama SM: Longitudinal follow-up of bone density and body composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy. J Clin Endocrinol Metab 2002;87:506-512. (Pubitemid 34158212)
6. Paterson WF, McNeill E, Young D, Donaldson MD: Auxological outcome and time to menarche following long-acting goserelin therapy in girls with central precocious or early puberty. Clin Endocrinol (Oxf) 2004;61:626-634. (Pubitemid 39540366)
7. Palmert MR, Mansfield MJ, Crowley WF Jr, Crigler JF Jr, Crawford JD, Boepple PA: Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty. J Clin Endocrinol Metab 1999;84:4480-4488.
8. Traggiai C, Perucchin PP, Zerbini K, Gastaldi R, De Biasio P, Lorini R: Outcome after depot gonadotrophin-releasing hormone agonist treatment for central precocious puberty: effects on body mass index and final height. Eur J Endocrinol 2005;153:463-464. (Pubitemid 41410503)
9. Arrigo T, De Luca F, Antoniazzi F, Galluzzi F, Segni M, Rosano M, Messina MF, Lombardo F: Reduction of baseline body mass index under gonadotropin-suppressive therapy in girls with idiopathic precocious puberty. Eur J Endocrinol 2004;150:533-537. (Pubitemid 38584705)
10. Pasquino AM, Pucarelli I, Accardo F, Demiraj V, Segni M, Di Nardo R: Long-term observation of 87 girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analogs: impact on adult height, body mass index, bone mineral content, and reproductive function. J Clin Endocrinol Metab 2008;93:190-195.
11. Boot AM, De Muinck Keizer-Schrama S, Pols HA, Krenning EP, Drop SL: Bone mineral density and body composition before and during treatment with gonadotropin-releasing hormone agonist in children with central precocious and early puberty. J Clin Endocrinol Metab 1998;83:370-373. (Pubitemid 28496508)
12. Shaw NJ, Crabtree NJ, Kibirige MS, Fordham JN: Ethnic and gender differences in body fat in British schoolchildren as measured by DXA. Arch Dis Child 2007;92:872-875. (Pubitemid 47535447)
13. Kagawa M, Kerr D, Uchida H, Binns CW: Differences in the relationship between BMI and percentage body fat between Japanese and Australian-Caucasian young men. Br J Nutr 2006;95:1002-1007. (Pubitemid 43805389)
14. Ehtisham S, Crabtree N, Clark P, Shaw N, Barrett T: Ethnic differences in insulin resistance and body composition in United Kingdom adolescents. J Clin Endocrinol Metab 2005;90:3963-3969. (Pubitemid 41058158)
15. Deurenberg P, Deurenberg-Yap M, Guricci S: Asians are different from Caucasians and from each other in their body mass index/ body fat per cent relationship. Obes Rev 2002;3:141-146. (Pubitemid 34815232)
16. Deurenberg P, Bhaskaran K, Lian PL: Singaporean Chinese adolescents have more subcutaneous adipose tissue than Dutch Caucasians of the same age and body mass index. Asia Pac J Clin Nutr 2003;12:261-265. (Pubitemid 38880710)
17. Chang CJ, Wu CH, Chang CS, Yao WJ, Yang YC, Wu JS, Lu FH: Low body mass index but high percent body fat in Taiwanese subjects: Implications of obesity cutoffs. Int J Obes Relat Metab Disord 2003;27:253-259.
18. Sweeting HN: Measurement and definitions of obesity in childhood and adolescence: a field guide for the uninitiated. Nutr J 2007;6:32.
19. Tanner JM, Whitehouse RH: Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976;51:170-179.
20. Greulich WW, Pyle SI: Radiographic Atlas of Skeletal Development of the Hand and Wrist, ed 2. Stanford, Stanford University Press, 1959.
21. Bayley N, Pinneau SR: Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr 1952;40:423-441.
22. Lim JS, Hwang JS, Park KD, Cheon GJ, Shin CH, Yang SW: Bone mineral density according to age, bone age, pubertal stages in Korean children and adolescents. J Clin Densitom 2010;13:68-76.
23. Lim JS, Hwang JS, Cheon GJ, Lee JA, Kim DH, Park KD, Yi KH: Gender differences in total and regional body composition changes as measured by dual-energy x-ray absorptiometry in Korean children and adolescents. J Clin Densitom 2009;12:229-237.
24. Song AK, Kim HJ, Suk HJ, Hwang JS, Hong CH: Serum IGF-I and IGFBP-3 in 919 healthy Korean children and adolescents: normal values and correlation with age, sex, height, body mass index and bone age. J Kor Soc Pediatr Endocrinol 2005;10:35-41.
25. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH: Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000;320:1240-1243. (Pubitemid 30240471)
26. Sopher AB, Thornton JC, Wang J, Pierson RN Jr, Heymsfield SB, Horlick M: Measurement of percentage of body fat in 411 children and adolescents: a comparison of dual-energy x-ray absorptiometry with a four-compartment model. Pediatrics 2004;113:1285-1290. (Pubitemid 38580694)
27. Gutin B, Litaker M, Islam S, Manos T, Smith C, Treiber F: Body-composition measurement in 9- to 11-year-old children by dual-energy x-ray absorptiometry, skinfold-thickness measurements, and bioimpedance analysis. Am J Clin Nutr 1996;63:287-292. (Pubitemid 26074685)
28. Fuller NJ, Wells JC, Elia M: Evaluation of a model for total body protein mass based on dual-energy x-ray absorptiometry: comparison with a reference four-component model. Br J Nutr 2001;86:45-52. (Pubitemid 32640250)
29. Glab E, Barg E, Wikiera B, Grabowski M, Noczynska A: Influence of GNRH analog therapy on body mass in central precocious puberty. Pediatr Endocrinol Diabetes Metab 2009;15:7-11.
30. Palmert MR, Radovick S, Boepple PA: The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. J Clin Endocrinol Metab 1998;83:1091-1096. (Pubitemid 28496375)
31. DiVall SA, Radovick S: Endocrinology of female puberty. Curr Opin Endocrinol Diabetes Obes 2009;16:1-4.
32. Kaplowitz PB: Link between body fat and the timing of puberty. Pediatrics 2008;121:S208-S217.
33. Paoletti AM, Serra GG, Cagnacci A, Vacca AM, Guerriero S, Solla E, Melis GB: Spontaneous reversibility of bone loss induced by gonadotropin-releasing hormone analog treatment. Fertil Steril 1996;65:707-710. (Pubitemid 26096905)
34. Antoniazzi F, Bertoldo F, Lauriola S, Sirpresi S, Gasperi E, Zamboni G, Tato L: Prevention of bone demineralization by calcium supplementation in precocious puberty during gonadotropin-releasing hormone agonist treatment. J Clin Endocrinol Metab 1999;84:1992-1996. (Pubitemid 30647023)
35. Caufriez A: The pubertal spurt: effects of sex steroids on growth hormone and insulin-like growth factor I. Eur J Obstet Gynecol Reprod Biol 1997;71:215-217.