RNA editing of Kv1.1 channels may account for reduced ictogenic potential of 4-aminopyridine in chronic epileptic rats

Epilepsia

Volumn 52, Issue 3, 2011, Pages 645-648

  Streit, Anne Kathrin ^a   Derst, Christian ^b   Wegner, Sven ^c   Heinemann, Uwe ^b   Zahn, Robert K ^b   Decher, Niels ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY HOSPITAL MARBURG   (Germany)

Author keywords

4 aminopyridine; Kv1.1 channel; RNA editing

Indexed keywords

4 AMINOPYRIDINE; KAINIC ACID; MESSENGER RNA; POTASSIUM CHANNEL KV1.1; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CHEMOSENSITIVITY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENTORHINAL CORTEX; EPILEPSY; EPILEPTIC STATE; GENE EXPRESSION; HETEROLOGOUS EXPRESSION; HIPPOCAMPUS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; RNA EDITING; XENOPUS;

4-AMINOPYRIDINE; ANIMALS; CONVULSANTS; DISEASE MODELS, ANIMAL; ENTORHINAL CORTEX; EPILEPSY; HIPPOCAMPUS; KV1.1 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; NEURONS; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, SPRAGUE-DAWLEY; RNA EDITING; TISSUE CULTURE TECHNIQUES;

EID: 79952558879     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.02986.x     Document Type: Article

References (15)

1. Bhalla T, Rosenthal JJ, Holmgren M, Reenan R. (2004) Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nat Struct Mol Biol 11:950-956. (Pubitemid 39315298)
2. Brusa R, Zimmermann F, Koh DS, Feldmeyer D, Gass P, Seeburg PH, Sprengel R. (1995) Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice. Science 270:1677-1680. (Pubitemid 26002446)
3. Decher N, Streit AK, Rapedius M, Netter MF, Marzian S, Ehling P, Schlichthorl G, Craan T, Renigunta V, Kohler A, Dodel RC, Navarro- Polanco RA, Preisig-Muller R, Klebe G, Budde T, Baukrowitz T, Daut J. (2010) RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels. EMBO J 29:2101-2113.
4. 2+ induced epileptiform activity in rat temporal cortex slices. Exp Brain Res 87:581-596.
5. Gabriel S, Njunting M, Pomper JK, Merschhemke M, Sanabria ER, Eilers A, Kivi A, Zeller M, Meencke HJ, Cavalheiro EA, Heinemann U, Lehmann TN. (2004) Stimulus and potassium-induced epileptiform activity in the human dentate gyrus from patients with and without hippocampal sclerosis. J Neurosci 24:10416-10430.
6. Higuchi M, Maas S, Single FN, Hartner J, Rozov A, Burnashev N, Feldmeyer D, Sprengel R, Seeburg PH. (2000) Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature 406:78-81. (Pubitemid 30460214)
7. Hoopengardner B, Bhalla T, Staber C, Reenan R. (2003) Nervous system targets of RNA editing identified by comparative genomics. Science 301:832-836. (Pubitemid 36962624)
8. Kortenbruck G, Berger E, Speckmann EJ, Musshoff U. (2001) RNA editing at the Q/R site for the glutamate receptor subunits GLUR2, GLUR5, and GLUR6 in hippocampus and temporal cortex from epileptic patients. Neurobiol Dis 8:459-468.
9. Li JB, Levanon EY, Yoon JK, Aach J, Xie B, Leproust E, Zhang K, Gao Y, Church GM. (2009) Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. Science 324:1210-1213.
10. Racine RJ. (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281-294.
11. Sommer B, Kohler M, Sprengel R, Seeburg PH. (1991) RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67:11-19. (Pubitemid 121001421)
12. Spencer SS, Spencer DD. (1994) Entorhinal-hippocampal interactions in medial temporal lobe epilepsy. Epilepsia 35:721-727. (Pubitemid 24278022)
13. Spyker DA, Lynch C, Shabanowitz J, Sinn JA. (1980) Poisoning with 4-aminopyridine: report of three cases. Clin Toxicol 16:487-497. (Pubitemid 10048631)
14. Tolner EA, Frahm C, Metzger R, Gorter JA, Witte OW, Lopes da Silva FH, Heinemann U. (2007) Synaptic responses in superficial layers of medial entorhinal cortex from rats with kainate-induced epilepsy. Neurobiol Dis 26:419-438. (Pubitemid 46561341)
15. Zahn RK, Tolner EA, Derst C, Gruber C, Veh RW, Heinemann U. (2008) Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats. Neurobiol Dis 29:186-200.