Stromal cell-derived factor-1/CXCR4 promotes IL-6 production in human synovial fibroblasts

Journal of Cellular Biochemistry

Volumn 112, Issue 4, 2011, Pages 1219-1227

  Chen, Hsien Te ^a,b,c   Tsou, Hsi Kai ^c,d,e   Hsu, Chin Jung ^a,b   Tsai, Chun Hao ^a   Kao, Cheng Hsing ^f,g   Fong, Yi Chin ^a,b   Tang, Chih Hsin ^b,h  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c FENG CHIA UNIVERSITY   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e JEN TEH JUNIOR COLLEGE OF MEDICINE   (Taiwan)

^f CHI MEI MEDICAL CENTER   (Taiwan)

^g SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^h CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

CXCR4; IL 6; OA; SDF 1

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; INTERLEUKIN 6; LUCIFERASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PLERIXAFOR; PROTEIN C JUN; PROTEIN KINASE B; SMALL INTERFERING RNA; STROMAL CELL DERIVED FACTOR 1ALPHA; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; OSTEOARTHRITIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; SYNOVIUM; TRANSCRIPTION REGULATION; UPREGULATION;

BLOTTING, WESTERN; CELLS, CULTURED; CHEMOKINE CXCL12; FIBROBLASTS; HETEROCYCLIC COMPOUNDS; HUMANS; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOARTHRITIS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TRANSCRIPTION FACTOR AP-1;

EID: 79952555959     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23043     Document Type: Article

References (28)

1. Bachelder RE, Wendt MA, Mercurio AM. 2002. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res 62:7203-7206. (Pubitemid 36025239)
2. Bantel H, Schmitz ML, Raible A, Gregor M, Schulze-Osthoff K. 2002. Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness. FASEB J 16:1832-1834.
3. Bartolome RA, Molina-Ortiz I, Samaniego R, Sanchez-Mateos P, Bustelo XR, Teixido J. 2006. Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion. Cancer Res 66:248-258. (Pubitemid 43166031)
4. Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS, Perretti M, Pitzalis C. 2002. Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID mice. Arthritis Rheum 46:824-836. (Pubitemid 34214266)
5. Borzi RM, Mazzetti I, Marcu KB, Facchini A. 2004. Chemokines in cartilage degradation. Clin Orthop Relat Res 427 Suppl:S53-S61. (Pubitemid 39362801)
6. Chiu YC, Yang RS, Hsieh KH, Fong YC, Way TD, Lee TS, Wu HC, Fu WM, Tang CH. 2007. Stromal cell-derived factor-1 induces matrix metalloprotease-13 expression in human chondrocytes. Mol Pharmacol 72:695-703.
7. Chiu YC, Lin CY, Chen CP, Huang KC, Tong KM, Tzeng CY, Lee TS, Hsu HC, Tang CH. 2009. Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- dependent pathway. J Immunol 183:2785-2792.
8. Clouet J, Vinatier C, Merceron C, Pot-vaucel M, Maugars Y, Weiss P, Grimandi G, Guicheux J. 2009. From osteoarthritis treatments to future regenerative therapies for cartilage. Drug Discov Today 14:913-925.
9. Graeve L, Baumann M, Heinrich PC. 1993. Interleukin-6 in autoimmune disease. Role of IL-6 in physiology and pathology of the immune defense. Clin Investig 71:664-671.
10. Grassl C, Luckow B, Schlondorff D, Dendorfer U. 1999. Transcriptional regulation of the interleukin-6 gene in mesangial cells. J Am Soc Nephrol 10:1466-1477. (Pubitemid 29297521)
11. Grimble RF. 1998. Nutritional modulation of cytokine biology. Nutrition 14:634-640. (Pubitemid 28345463)
12. Hasselblatt P, Rath M, Komnenovic V, Zatloukal K, Wagner EF. 2007. Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase. Proc Natl Acad Sci USA 104:17105-17110. (Pubitemid 350210999)
13. Huang YC, Hsiao YC, Chen YJ, Wei YY, Lai TH, Tang CH. 2007. Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-kappaB-dependent pathway in human lung cancer cells. Biochem Pharmacol 74:1702-1712.
14. Huang CY, Lee CY, Chen MY, Yang WH, Chen YH, Chang CH, Hsu HC, Fong YC, Tang CH. 2009. Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. J Cell Physiol 221:204-212.
15. Jones SA. 2005. Directing transition from innate to acquired immunity: Defining a role for IL-6. J Immunol 175:3463-3468. (Pubitemid 41292002)
16. Kanbe K, Takagishi K, Chen Q. 2002. Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4. Arthritis Rheum 46:130-137. (Pubitemid 34121659)
17. Kanbe K, Takemura T, Takeuchi K, Chen Q, Takagishi K, Inoue K. 2004. Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is involved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis. J Bone Joint Surg Br 86:296-300. (Pubitemid 38386874)
18. Lu DY, Tang CH, Yeh WL, Wong KL, Lin CP, Chen YH, Lai CH, Chen YF, Leung YM, Fu WM. 2009. SDF-1alpha up-regulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NF-kappaB-dependent pathway in microglia. Eur J Pharmacol 613:146-154.
19. Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S. 1993. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA 90:10193-10197. (Pubitemid 23328278)
20. Mor A, Abramson SB, Pillinger MH. 2005. The fibroblast-like synovial cell in rheumatoid arthritis: A key player in inflammation and joint destruction. Clin Immunol 115:118-128. (Pubitemid 40693079)
21. Persson E, Voznesensky OS, Huang YF, Lerner UH. 2005. Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts. Bone 37:513-529. (Pubitemid 41317325)
22. Tang CH, Chiu YC, Tan TW, Yang RS, Fu WM. 2007. Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J Immunol 179:5483-5492.
23. Tang CH, Chuang JY, Fong YC, Maa MC, Way TD, Hung CH. 2008. Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-kappaB pathways and promotes osteoclastogenesis in human oral cancer cells. Carcinogenesis 29:1483-1492.
24. Wagner EF, Eferl R. 2005. Fos/AP-1 proteins in bone and the immune system. Immunol Rev 208:126-140. (Pubitemid 41746389)
25. Wright AA, Cook C, Abbott JH. 2009. Variables associated with the progression of hip osteoarthritis: A systematic review. Arthritis Rheum 61:925-936.
26. Yokota K, Miyazaki T, Hirano M, Akiyama Y, Mimura T. 2006. Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Rheumatol 33:463-471. (Pubitemid 43334566)
27. Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa T, Fujikawa K, Okada Y. 2000. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis 59:455-461. (Pubitemid 30395603)
28. Zheng H, Dai T, Zhou B, Zhu J, Huang H, Wang M, Fu G. 2008. SDF-1alpha/ CXCR4 decreases endothelial progenitor cells apoptosis under serum deprivation by PI3K/Akt/eNOS pathway. Atherosclerosis 201:36-42.