Hypoglycaemia: Its pathophysiology in insulin treated diabetes and hypoglycaemia unawareness

British Journal of Diabetes and Vascular Disease

Volumn 11, Issue 1, 2011, Pages 6-9

  Heller, Simon R ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; GLUCAGON; GLUCOSE; INSULIN;

ADRENERGIC SYSTEM; ARTICLE; DIABETES MELLITUS; DISEASE DURATION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; SELF CARE; TRAINING; TREATMENT RESPONSE;

EID: 79952540615     PISSN: 14746514     EISSN: None     Source Type: Journal    
DOI: 10.1177/1474651410397248     Document Type: Article

References (18)

1. Pramming S., Thorsteinsson B., Bendtson I. et al. Symptomatic hypoglycaemia in 411 type 1 diabetic patients. Diabet Med 1991 ; 8: 217-22.
2. Pedersen-Bjergaard U., Pramming S., Heller SR et al. Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection. Diabetes Metab Res Rev 2004 ; 20: 479-86. (Pubitemid 40028649)
3. UK Hypoglycaemia Study Group. Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia 2007 ; 50: 1140-47.
4. The Diabetes Control and Complications Trial Research G. Epidemiology of severe hypoglycemia in the Diabetes Control and Complications Trial. Am J Med 1991 ; 90: 450-9.
5. Bott S., Bott U., Berger M. et al. Intensified insulin therapy and the risk of severe hypoglycaemia. Diabetologia 1997 ; 40: 926-32. (Pubitemid 27316573)
6. Cryer PE Hierarchy of physiological responses to hypoglycemia: relevance to clinical hypoglycemia in type I (insulin dependent) diabetes mellitus. Horm Metab Res 1997 ; 29: 92-9.
7. Heller SR, Macdonald IA The measurement of cognitive function during acute hypoglycaemia: experimental limitations and their effect on the study of hypoglycaemia unawareness. Diabet Med 1996 ; 13: 607-15. (Pubitemid 26232500)
8. Bolli GB, De Feo P., Compagnucci P. et al. Abnormal glucose counterregulation in IDDM.Interaction of anti- insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 1983 ; 32: 134-41. (Pubitemid 13180346)
9. Banarer S., McGregor VP, Cryer PE Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response. Diabetes 2002 ; 51: 958-65. (Pubitemid 34438337)
10. Amiel SA, Sherwin RS, Simonson DC et al. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 1988 ; 37: 901-7. (Pubitemid 19043718)
11. Heller SR, Cryer PE Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after one episode of hypoglycemia in non-diabetic humans. Diabetes 1991 ; 40: 223-6.
12. Cryer PE Hypoglycemia: still the limiting factor in the glycemic management of diabetes. Endocr Pract 2008 ; 14: 750-6.
13. Cranston I., Lomas J., Maran A. et al. Restoration of hypoglycaemia unawareness in patients with long- duration insulin-dependent diabetes. Lancet 1994 ; 344: 283-7. (Pubitemid 24230294)
14. Dagogo-Jack S., Rattarasarn C., Cryer PE Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 1994 ; 43: 1426-34.
15. Bode BW, Steed RD, Davidson PC Reduction in severe hypoglycemia with long-term continuous subcutaneous insulin infusion in type I diabetes. Diabetes Care 1996 ; 19: 324-7. (Pubitemid 26115454)
16. Muhlhauser I., Jorgens V., Berger M. et al. Bicentric evaluation of a teaching and treatment programme for type 1 (insulin-dependent) diabetic patients: improvement of metabolic control and other measures of diabetes care for up to 22 months. Diabetologia 1983 ; 25: 470-6. (Pubitemid 14200881)
17. DAFNE Study Group. Training in flexible, intensive insulin management to enable dietary freedom in people with type 1 diabetes: dose adjustment for normal eating (DAFNE) randomised controlled trial. BMJ 2002 ; 325: 746-51.
18. Cox DJ, Gonder-Frederick L., Polonsky W. et al. Blood glucose awareness training (BGAT-2): long-term benefits. Diabetes Care 2001 ; 24: 637-42. (Pubitemid 32888840)