Synthesis of 1H-Pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line

Archiv der Pharmazie

Volumn 344, Issue 3, 2011, Pages 197-204

  El Gamal, Mohammed I ^a,b   Sim, Tae Bo ^a   Hong, Jun Hee ^c   Cho, Jung Hyuck ^a   Yoo, Kyung Ho ^a   Oh, Chang Hyun ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Chosun University   (South Korea)

Author keywords

1H Pyrazole 1 carboxamide; 3,4 Diarylpyrazole; A375; Antiproliferative activity; Melanoma

Indexed keywords

1H PYRAZOLE 1 CARBOXAMIDE DERIVATIVE; 3 (3 CHLORO 5 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) N [2 (PYRROLIDIN 1 YL)ETHYL] 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 HYDROXYPHENYL) N (2 MORPHOLINOETHYL) 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 HYDROXYPHENYL) N [2 (2 METHYLPIPERIDIN 1 YL)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 HYDROXYPHENYL) N [2 (2,6 DIMETHYLMORPHOLINO)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 HYDROXYPHENYL) N [2 (4 METHYLPIPERAZIN 1 YL)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 HYDROXYPHENYL) N [2 (DIETHYLAMINO)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 HYDROXYPHENYL) N [2 (DIMETHYLAMINO)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 HYDROXYPHENYL) N [2 (PIPERIDIN 1 YL)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 METHOXYPHENYL) 4 (PYRIDIN 4 YL) N [2 (PYRROLIDIN 1 YL)ETHYL] 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 METHOXYPHENYL) N (2 MORPHOLINOETHYL) 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 METHOXYPHENYL) N [2 (2 METHYLPIPERIDIN 1 YL)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 METHOXYPHENYL) N [2 (2,6 DIMETHYLMORPHOLINO)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 METHOXYPHENYL) N [2 (4 METHYLPIPERAZIN 1 YL)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 METHOXYPHENYL) N [2 (DIETHYLAMINO)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 METHOXYPHENYL) N [2 (DIMETHYLAMINO)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; 3 (3 CHLORO 5 METHOXYPHENYL) N [2 (PIPERIDIN 1 YL)ETHYL] 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; ANTINEOPLASTIC AGENT; N [2 (4 ACETYLPIPERAZIN 1 YL)ETHYL] 3 (3 CHLORO 5 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; N [2 (4 ACETYLPIPERAZIN 1 YL)ETHYL] 3 (3 CHLORO 5 METHOXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOLE 1 CARBOXAMIDE; PYRAZOLE DERIVATIVE; SORAFENIB; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MELANOMA CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MELANOMA; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952524606     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000057     Document Type: Article

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