An absolute structure template for a unique voltage-gated sodium channel binding site

MedChemComm

Volumn 1, Issue 1, 2010, Pages 45-49

  Palmer, Rex A ^a   Potter, Brian S ^a   Leach, Michael J ^b   Jenkins, Terence C ^c   Chowdhry, Babur Z ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF GREENWICH   (United Kingdom)

^c Morvus Technology Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 6 FLUOROMETHYL 5 (2,3,5 TRICHLOROPHENYL)PYRIMIDINE; HYDROGEN; MESYLIC ACID DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; BINDING SITE; CHIRALITY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENANTIOMER; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; RECEPTOR BINDING; SOLID STATE; X RAY CRYSTALLOGRAPHY;

EID: 79952511392     PISSN: 20402503     EISSN: 20402511     Source Type: Journal    
DOI: 10.1039/c0md00043d     Document Type: Article

References (12)

1. M. J. Leach, A. D. Randall, A. Stefani and A. H. Hainsworth, in Antiepileptic Drugs;, R. H. Levy,,, R. H. Mattson,,, B. S. Meldrum,,, E. Perucca,, eds.; Lippincott, Williams & Wilkins: USA 2002, 363-369, 5th edition
2. A. H. Hainsworth A. Stefani P. Calabresi T. W. Smith M. J. Leach CNS Drug Rev. 2000 6 111 134
3. L. Caputi A. H. Hainsworth F. Lavaroni M. J. Leach N. C. McNaughton N. B. Mercuri A. D. Randall F. Spadoni J. H. Swan A. Stefani Brain Res. 2001 919 259 268
4. A. H. Hainsworth N. C. McNaughton A. Pereverzev T. Schneider A. D. Randall Eur. J. Pharmacol. 2003 467 77 80
5. S. P. H. Alexander, A. Mathie and J. A. Peters, Brit. J. Pharm. (Guide to Receptors & Channels 4th Ed.) 2009, 158, Supplement 1, S127-S128; S146-S147
6. D. R. Riddall M. J. Leach J. Garthwaite Mol. Pharmacol. 2006 69 278 287
7. H. D. Flack Acta Crystallogr., Sect. A: Found. Crystallogr. 1983 39 876 881
8. C.L.Barnes ORTEP-3 for Windows-a version of ORTEP-III with a Graphical User Interface (GUI). J. Appl. Cryst., 30 (1997), 30, pp. 568-589 [Based on ORTEP-III (v 1.0.3) by C.K. Johnson and M.N. Burnett.]
9. E. A. Merrit D. J. Bacon Raster 3D Graphics version 2.7c. Methods Enzymol. 1997 277 505 524
10. M. F. C. Ladd, R. A. Palmer, Structure Determination by X-ray Crystallography, Klewer-Plenum: N.Y., USA (2003) p503, 4th Edition
11. N. B. Cronin A. O'Reilly H. Duclohier B. A. Wallace J. Biol. Chem. 2003 278 10675 10682
12. V. Yarov-Yarovoy J. Brown E. M. Sharp J. J. Clare T. Scheuer W. A. Catterall J. Biol. Chem. 2000 276 20 27