메뉴 건너뛰기




Volumn 23, Issue 4, 2011, Pages 361-366

Large scale chiral chromatography for the separation of an enantiomer to accelerate drug development

Author keywords

chiral stationary phase; enantiomer; multicolumn continuous chromatography

Indexed keywords

ARTICLE; CHIRAL CHROMATOGRAPHY; CHIRALITY; COLUMN CHROMATOGRAPHY; COMPARATIVE STUDY; COST EFFECTIVENESS ANALYSIS; ENANTIOMER; MULTICOLUMN CONTINUOUS CHROMATOGRAPHY; PRIORITY JOURNAL;

EID: 79952495622     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20931     Document Type: Article
Times cited : (10)

References (18)
  • 1
    • 0003452450 scopus 로고
    • In: Crane J., editor. Chromatographic science series, Vol. New York: Marcel Dekker.
    • Zief M,. Chromatographic chiral separations. In:, Crane J, editor. Chromatographic science series, Vol. 40. New York: Marcel Dekker; 1988.
    • (1988) Chromatographic Chiral Separations , vol.40
    • Zief, M.1
  • 3
    • 0035847205 scopus 로고    scopus 로고
    • Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers
    • Francotte ER,. Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers. J Chromatogr A 2001; 906: 379-397.
    • (2001) J Chromatogr A , vol.906 , pp. 379-397
    • Francotte, E.R.1
  • 4
    • 50849098166 scopus 로고    scopus 로고
    • Use of large-scale chromatography in the preparation of armodafinil
    • Hauck W, Adam P, Bobier C, Landmesser N,. Use of large-scale chromatography in the preparation of armodafinil. Chirality 2008; 20: 896-899.
    • (2008) Chirality , vol.20 , pp. 896-899
    • Hauck, W.1    Adam, P.2    Bobier, C.3    Landmesser, N.4
  • 5
    • 0026017111 scopus 로고
    • Optimization of experimental conditions in preparative liquid chromatography: Trade-offs between recovery yield and production rate
    • Golshan-Shirazi S, Guiochon G,. Optimization of experimental conditions in preparative liquid chromatography: trade-offs between recovery yield and production rate. J Chromatogr 1991; 536: 57-73.
    • (1991) J Chromatogr , vol.536 , pp. 57-73
    • Golshan-Shirazi, S.1    Guiochon, G.2
  • 6
    • 0002906746 scopus 로고
    • Framework for maximizing throughput in preparative liquid chromatography
    • Knox JH, Pyper HM,. Framework for maximizing throughput in preparative liquid chromatography. J Chromatogr 1986; 363: 1-30.
    • (1986) J Chromatogr , vol.363 , pp. 1-30
    • Knox, J.H.1    Pyper, H.M.2
  • 9
  • 10
    • 0001892469 scopus 로고
    • 1(R)-(2,6-cis-dimethylmorpholino)-3(S)-(p-tert-butylphenyl)cyclopentane: A representative of a novel, potent class of bio-rationally designed fungicides
    • Huxley-Tencer A, Francotte E, Bladocha-Moreau M,. 1(R)-(2,6-cis- dimethylmorpholino)-3(S)-(p-tert-butylphenyl)cyclopentane: a representative of a novel, potent class of bio-rationally designed fungicides. Pestic Sci 1992; 34: 65-74.
    • (1992) Pestic Sci , vol.34 , pp. 65-74
    • Huxley-Tencer, A.1    Francotte, E.2    Bladocha-Moreau, M.3
  • 11
    • 0028327619 scopus 로고
    • Preparative chromatographic resolution of racemates on chiral stationary phases on laboratory and production scales by closed-loop recycling chromatography
    • DOI 10.1016/0021-9673(94)80423-0
    • Dingenen J, Kinkel JN,. Preparative chromatographic resolution of racemates on chiral stationary phases on laboratory and production scales by closed-loop recycling chromatography. J Chromatogr A 1994; 666: 627-650. (Pubitemid 24138253)
    • (1994) Journal of Chromatography A , vol.666 , Issue.1-2 , pp. 627-650
    • Dingenen, J.1    Kinkel, J.N.2
  • 12
    • 0034282314 scopus 로고    scopus 로고
    • The "vARICOL" process: A new multicolumn continuous chromatographic process
    • Ludemann-Hombourger O, Nicoud RM, Bailly M,. The "VARICOL" process: a new multicolumn continuous chromatographic process. Sep Sci Technol 2000; 35: 1829-1862.
    • (2000) Sep Sci Technol , vol.35 , pp. 1829-1862
    • Ludemann-Hombourger, O.1    Nicoud, R.M.2    Bailly, M.3
  • 13
    • 0027414431 scopus 로고
    • Preparative resolution of praziquantel enantiomers by simulated counter-current chromatography
    • DOI 10.1016/0021-9673(93)83007-F
    • Ching CB, Lim BG, Lee EJD,;, Ng SC,. Preparative resolution of praziquantel enantiomers by simulated countercurrent chromatography. J Chromatogr 1993; 634: 215-219. (Pubitemid 23101233)
    • (1993) Journal of Chromatography , vol.634 , Issue.2 , pp. 215-219
    • Ching, C.B.1    Lim, B.G.2    Lee, E.J.D.3    Ng, S.C.4
  • 14
    • 0029043384 scopus 로고
    • Complete design of a simulated moving bed
    • Charton F, Nicoud RM,. Complete design of a simulated moving bed. J Chromatogr A 1995; 702: 97-112.
    • (1995) J Chromatogr A , vol.702 , pp. 97-112
    • Charton, F.1    Nicoud, R.M.2
  • 15
    • 0030965825 scopus 로고    scopus 로고
    • Optimal operation of simulated moving bed units for nonlinear chromatographic separations
    • DOI 10.1016/S0021-9673(97)00048-4, PII S0021967397000484
    • Mazzotti M, Storti G, Morbidelli M,. Optimal operation of simulated moving bed units for nonlinear chromatographic separations. J Chromatogr A 1997; 769: 3-24. (Pubitemid 27210291)
    • (1997) Journal of Chromatography A , vol.769 , Issue.1 , pp. 3-24
    • Mazzotti, M.1    Storti, G.2    Morbidelli, M.3
  • 16
    • 0027197687 scopus 로고
    • Preparative scale enantioseparation of a chiral epoxide: Comparison of liquid chromatography and simulated moving bed adsorption technology
    • Nicoud RM, Fuchs G, Adam P, et al. Preparative scale enantioseparation of a chiral epoxide: comparison of liquid chromatography and simulated moving bed adsorption technology. Chirality 1993; 5: 267-271. (Pubitemid 23237742)
    • (1993) Chirality , vol.5 , Issue.4 , pp. 267-271
    • Nicoud, R.-M.1    Fuchs, G.2    Adam, P.3    Bailly, M.4    Kusters, E.5    Antia, F.D.6    Reuille, R.7    Schmid, E.8
  • 18
    • 0037083064 scopus 로고    scopus 로고
    • Application of the "VARICOL" process to the separation of the isomers of the SB-553261 racemate
    • DOI 10.1016/S0021-9673(01)01568-0, PII S0021967301015680
    • Ludemann-Hombourger O, Pigorini G, Nicoud RM, Ross DS, Terfloth G,. Application of the "VARICOL" process to the separation of the isomers of the SB-553261 racemate. J Chromatogr A 2002; 947: 59-68. (Pubitemid 34124082)
    • (2002) Journal of Chromatography A , vol.947 , Issue.1 , pp. 59-68
    • Ludemann-Hombourger, O.1    Pigorini, G.2    Nicoud, R.M.3    Ross, D.S.4    Terfloth, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.