Factors derived from preeclamptic placentas perturb polarity protein PARD-3 expression and distribution in endothelial cells

Reproductive Sciences

Volumn 18, Issue 2, 2011, Pages 164-171

  Zhao, Juan ^a,b   Gu, Yang ^a   Fan, Ruping ^a   Groome, Lynn J ^a   Wang, Yuping ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

aPKC ; Endothelium; PARD 3; Preeclampsia; VE cadherin

Indexed keywords

POLARITY PROTEIN PARTITIONING DEFECTIVE 3; POLARITY PROTEIN PARTITIONING DEFECTIVE 6; PROTEIN; PROTEIN KINASE C LAMBDA; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; PLACENTA; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANTIGENS, CD; CADHERINS; CAPILLARY PERMEABILITY; CELL CYCLE PROTEINS; CELL POLARITY; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DOWN-REGULATION; ENDOTHELIAL CELLS; FEMALE; HUMANS; INTERCELLULAR JUNCTIONS; ISOENZYMES; MEMBRANE PROTEINS; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PROTEIN KINASE C; SIGNAL TRANSDUCTION; UMBILICAL VEINS;

EID: 79952492490     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719110382920     Document Type: Article

References (18)

1. Wang Y, Gu Y, Granger DN, Roberts JM, Alexander JS. Endothelial junctional protein redistribution and increased monolayer permeability in HUVECs isolated during preeclampsia. Am J Obstet Gynecol. 2002;186(2):214-220. (Pubitemid 34165436)
2. Wang Y, Lewis DF, Gu Y, Zhang Y, Alexander JS, Granger DN. Placental trophoblast-derived factors diminish endothelial barrier function. J Clin Endocrinol Metabol. 2004;89(5):2421-2428. (Pubitemid 38619885)
3. Groten T, Kreienberg R, Fialka I, Huber L, Wedlich D. Altered subcellular distribution of cadherin-5 in endothelial cells caused by the serum of pre-eclamptic patients. Mol Hum Reprod. 2000;6(11):1027-1032.
4. Zhang Y, Gu Y, Li H, Lucas MJ, Wang Y. Increased endothelial monolayer permeability is induced by serum from women with preeclampsia but not by serum from women with normal pregnancy or that are not pregnant. Hypertens Pregnancy. 2003;22(1):121-131.
5. Schmoranzer J, Fawcett JP, Segura M, et al. Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration. Curr Biol. 2009;19(13):1065-1074.
6. Zen K, Yasui K, Gen Y, et al. Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma. Oncogene. 2009;28(32):2910-2918.
7. Pegtel DM, Ellenbroek SI, Mertens AE, van der Kammen RA, de Rooij J, Collard JG. The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol. 2007;17(19):1623-1634. (Pubitemid 47503803)
8. Joberty G, Petersen C, Gao L, Macara IG. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000;2(8):531-539.
9. Lin D, Edwards AS, Fawcett JP, Mbamalu G, Scott JD, Pawson T. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. 2000;2(8):540-547.
10. Kanzaki M, Mora S, Hwang JB, Saltiel AR, Pessin JE. Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. J Cell Biol. 2004; 164(2):279-290. (Pubitemid 38133947)
11. Izumi Y, Hirose T, Tamai Y, et al. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol. 1998;143(1):95-106. (Pubitemid 28480520)
12. Suzuki A, Ishiyama C, Hashiba K, Shimizu M, Ebnet K, Ohno S. aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci. 2002;115(pt 18):3565-3573.
13. Ebnet K, Suzuki A, Horikoshi Y, et al. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J. 2001;20(14):3738-3748. (Pubitemid 32691785)
14. Wang Y, Adair CD, Coe L, Weeks JW, Lewis DF, Alexander JS. Activation of endothelial cells in preeclampsia: Increased neutrophil-endothelial adhesion correlates with up-regulation of adhesion molecule P-selectin in human umbilical vein endothelial cells isolated from preeclampsia. J Soc Gynecol Investig. 1998;5(5):237-243. (Pubitemid 28427512)
15. Wang Y, Adair CD, Weeks JW, Lewis DF, Alexander JS. Increased neutrophil-endothelial adhesion induced by placental factors is mediated by platelet-activating factor in preeclampsia. J Soc Gynecol Investig. 1999;6(3):136-141. (Pubitemid 29264902)
16. Gu Y, Lewis DF, Alexander JS, Wang Y. Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia. Reprod Sci. 2008;16(5):479-488.
17. Suzuki A, Yamanaka T, Hirose T, et al. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol. 2001; 152(6):1183-1196. (Pubitemid 34280176)
18. Wang Y, Du D, Fang L, et al. Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. EMBO J. 2006;25(21):5058-5070. (Pubitemid 44658524)