In vitro cytotoxicity of melleolide antibiotics: Structural and mechanistic aspects

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 7, 2011, Pages 2003-2006

  Bohnert, Markus ^a   Miethbauer, Sebastian ^a   Dahse, Hans Martin ^b   Ziemen, Johannes ^a   Nett, Markus ^b   Hoffmeister, Dirk ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Antibiotics; Armillaria; Cytotoxicity; Melleolide; Natural product

Indexed keywords

13 HYDROXY DIHYDROMELLEOLIDE; 13,14 DIHYDROXYLATED DERIVATIVE; 4 O METHYLARMILLARIDIN; 5' METHOXY 6' CHLOROARMILLANE; 6' CHLORO 13 HYDROXYDIHYDROMELLOLIDE; 6' CHLOROEVERNINIC ACID; ANTIBIOTIC AGENT; ARMELLIDE; ARMELLIDE B; ARMILLARIDIN; ARMILLARIN; ARNAMIAL; DEHYDROARMILLYLORSELLINATE; MELLEOLIDE; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARMILLARIA; ARTICLE; BREATHING; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN K 562; DNA REPLICATION; DNA SYNTHESIS; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG STRUCTURE; HUMAN; HYDROXYLATION; IC 50; IN VITRO STUDY; LEUKEMIA CELL LINE; PROTON NUCLEAR MAGNETIC RESONANCE; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION; TRANSLATION REGULATION;

ANTI-BACTERIAL AGENTS; BASIDIOMYCOTA; CELL LINE, TUMOR; DNA; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; SALICYLATES; SESQUITERPENES;

ARMILLARIA; BASIDIOMYCOTA;

EID: 79952486470     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.026     Document Type: Article

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