Serotonin 5-HT4 receptors in the nucleus accumbens are specifically involved in the appetite suppressant and not locomotor stimulant effects of MDMA ('ecstasy')

Psychopharmacology

Volumn 213, Issue 2-3, 2011, Pages 355-363

  Francis, H M ^a   Kraushaar, N J ^a   Hunt, L R ^a   Cornish, J L ^a  

^a MACQUARIE UNIVERSITY   (Australia)

Author keywords

Appetite; Ecstacy; Locomotor; Nucleus accumbens; Weight loss

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APPETITE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FLUID INTAKE; FOOD INTAKE; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RECEPTOR BLOCKING; REGULATORY MECHANISM; WEIGHT REDUCTION; WISTAR RAT;

ANIMALS; APPETITE DEPRESSANTS; DRINKING; EATING; MALE; MICROINJECTIONS; MOTOR ACTIVITY; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NUCLEUS ACCUMBENS; PIPERIDINES; PROPANE; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN 5-HT4 RECEPTOR ANTAGONISTS; WEIGHT LOSS;

EID: 79952485836     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-1982-9     Document Type: Article

References (37)

1. Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-152 (Pubitemid 29292403)
2. Bilsky EJ, Hubbell CL, Delconte JD, Reid LD (1991) MDMA produces a conditioned place preference and elicits ejaculation in male rats: a modulatory role for the endogenous opiods. Pharmacol Biochem Behav 40:443-47
3. Blundell JE (1984) Serotonin and appetite. Neuropharmacology 23:1537-1551
4. Callaway CW, Wing LL, Geyer MA (1990) Serotonin release contributes to the locomotor stimulant effects of 3, 4-methylenedioxymethamphetamine in rats. J Pharmacol Exp Ther 254:456-64 (Pubitemid 20262081)
5. Callaway CW, Johnson MP, Gold LH, Nichols DE, Geyer MA (1991) Amphetamine derivatives induce locomotor hyperactivity by acting as indirect serotonin agonists. Psychopharmacology (Berl) 104:293-301
6. Cance JD, Ashley OS, Penne MA (2005) Unhealthy weight control behaviors and MDMA (Ecstasy) use among adolescent females. J Adolesc Health 37:409
7. Clifton PG, Kennett GA (2006) Monoamine binding receptors as drug targets for the treatment of obesity. CNS Neurol Disord Drug Target 5:293-312
8. Compan V, Zhou M, Grailhe R, Gazzara RA, Martin R, Gingrich J, Dumuis A, Brunner D, Bockaert J, Hen R (2004) Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci 24:412-9 (Pubitemid 38112372)
9. Cooper SJ, Al-Naser HA (2006) Dopaminergic control of food choice: contrasting effects of SKF 38393 and quinpirole on high-palatability food preference in the rat. Neuropharmacology 50:953-963 (Pubitemid 44208835)
10. Curran HV, Robjant K (2006) Eating attitudes, weight concerns and beliefs about drug effects in women who use ecstasy. J Psychopharmacol 20:425-431
11. Degenhardt L, Roxburgh A, Dunn M, Campbell G, Bruno R, Kinner SA, George J, Quinn B, White N, Topp L (2009) The epidemiology of ecstasy use and harms in Australia. Neuropsychobiol 60:176-187
12. Domenech T, Beleta J, Fernandez AG, Gristwood RW, Cruz Sanchez F, Tolosa E, Palacios JM (1994) Identification and characterization of serotonin 5-HT4 receptor binding sites in human brain: comparison with other mammalian species. Mol Brain Res 21:176-180 (Pubitemid 24034924)
13. Dourish CT, Hutson PH, Curzon G (1985) Characteristics of feeding indiced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Brain Res Bull 15:377-384 (Pubitemid 16223123)
14. Fletcher PJ, Korth KM, Robinson SR, Baker GB (2002) Multiple 5- HT receptors are involved in the effects of acute MDMA treatment: studies on locomotor activity and responding for conditioned reinforcement. Psychopharmacology (Berl) 162:282-91 (Pubitemid 34762287)
15. Fletcher PJ, Sinyard J, Higgins GA (2006) The effects of the 5-HT (2C) receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists. Psychopharmacology (Berl) 187:515-25 (Pubitemid 44200523)
16. Frith CH, Chang LW, Lattin DL, Walls RC, Hamm J, Doblin R (1987) Toxicity of methylenedioxymethamphetamine (MDMA) in the dog and rat. Fundam Appl Toxicol 9:110-119
17. Gold LH, Koob GF, Geyer MA (1988) Stimulant and hallucinogenic behavioral profiles of 3, 4-methylenedioxymethamphetamine and N-ethyl-3, 4-methylenedioxyamphetamine in rats. J Pharmacol Exp Ther 247:547-55
18. Hegde SS, Bonhaus DW, Johnson LG, Leung E, Clark RD, Eglen RM (1995) RS39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br J Pharmacol 115:1087-1095
19. Jean A, Conductier G,Manrique C, Bouras C, Berta P, Hen R, CharnayY, Bockaert J, Compan V (2007) Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proc Natl Sci USA 104:16335-40 (Pubitemid 350099405)
20. Kelly PH, Seviour PW, Iverson SD (1975) Amphetamine and apormorphine responses in the rat following 6 OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res 94:507-522
21. Koob GF, Riley SJ, Smith SC, Robbins TW (1978) Effects of 6- hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat. J Physiol Psychol 92:917-27 (Pubitemid 9036050)
22. Laraway S, Snycerski S, Poling A (2003) MDMA and performance under a progressive ratio schedule of water delivery. Exp Clin Psychopharm 11:309-316 (Pubitemid 37433444)
23. Lucas JJ, Yamamoto A, Scearce-Levie K, Sandou F, Hen R (1998) Absence of fenluramine induced anorexia and reduced c-fos induction the the hypothalamus and central amygdaloid complex of serotonin 1B knockout mice. J Neurosci 18:5537-5544 (Pubitemid 28311968)
24. McGregor A, Baker G, Roberts DC (1996) Effect of 6-hydroxydopamine lesions of the medial prefrontal cortex on intravenous cocaine self-administration under a progressive ratio schedule of reinforcement. Pharmacol Biochem Behav 53:5-9
25. McMahon LR, Cunningham KA (1999) Antagonism of 5- hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. J Pharmacol Exp Ther 291:300-7
26. National Health and Medical Research Council (2004) The Australian code of practice for the care and use of animals for scientific purposes. Commonwealth Department of Health and Family Services, Australian Government Publishing Service, Canberra
27. Parrott AC (2001) Human psychopharmacology of ecstasy (MDMA): a review of 15 years of empirical research. Hum Psychopharmacol 16:557-577
28. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates, 4th edn. Academic Press, New York
29. Reavill C, Hatcher JP, Lewis VA, Sanger GJ, Hagan J (1998) 5-HT4 receptor antagonism does not affect motor and reward mechanisms in the rat. Eur J Pharmacol 357:115-20
30. Rochester JA, Kirchner JT (1999) Ecstasy (3, 4- methylenedioxymethamphetamine): history, neurochemitry and toxicology. J Am Board Fam Pract 12:137-142
31. Spanos LJ, Yamamoto BK (1989) Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat. Pharmacol Biochem Behav 32:835-40 (Pubitemid 19210262)
32. Stock SL, Goldberg E, Corbett S, Katzman DK (2002) Substance use in female adolescents with eating disorders. J Adolesc Health 31:176-82 (Pubitemid 34786784)
33. Stratford TR, Kelley AE (1997) GABA in the nucleus accumbens shell participates in the central regulation of feeding behaviour. J Neurosci 17:4434-4440 (Pubitemid 27220634)
34. United Nations Office on Drugs and Crime (UNDOC) (2008) World drug report (online). UNDOC, New York
35. Vickers SP, Clifton PG, Dourish CT, Tecott LH (1999) Reduced satiating effect of d-fenfluramine in serotonin 5HT(sub 2C) receptor mutant mice. Psychopharmacology 143:309-314 (Pubitemid 29204986)
36. Waeber C, Sebben M, Nieoullon A, Bockaert J, Dumuis A (1994) Regional distribution and ontogeny of 5-HT4 binding sites in the rodent brain. Neuropharmacology 33:527-541 (Pubitemid 24168725)
37. White SR, Obradovic T, Imel KM, Wheaton MJ (1996) The effects of methylenedioxymethamphetamine (MDMA, "Ecstasy") on monoamine neurotransmission in the central nervous system. Prog Neurobiol 49:455-479 (Pubitemid 26312773)