Empathy: Shared circuits and their dysfunctions;Empatía: Circuitos comunes y sus disfunciones

Dialogues in Clinical Neuroscience

Volumn 12, Issue 4, 2010, Pages 546-552

  Thioux, Marc ^a   Keysers, Christian ^a  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

Action; Autism; Empathy; Mirror neuron; Sensation; Simulation

Indexed keywords

ARTICLE; AUTISM; EMOTION; EMPATHY; HUMAN; MENTAL HEALTH; SOCIAL INTERACTION; SOMATOSENSORY SYSTEM; TOUCH; ANIMAL; BRAIN; BRAIN MAPPING; NERVE TRACT; PAIN; PATHOLOGY; PATHOPHYSIOLOGY; REVIEW;

ANIMALS; AUTISTIC DISORDER; BRAIN; BRAIN MAPPING; EMPATHY; HUMANS; NEURAL PATHWAYS; PAIN;

EID: 79952474295     PISSN: 12948322     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. di Pellegrino G, Fadiga L, Fogassi L, Gallese V, Rizzolatti G. Understanding motor events: a neurophysiological study. Exp Br Res. 1992;91:176-180.
2. Gallese V, Fadiga L, Fogassi L, Rizzolatti G. Action recognition in the premotor cortex. Brain. 1996;119(Pt 2):593-609.
3. Keysers C, Kohler E, Umiltà MA, Nanetti L, Fogassi L, Gallese V. Audiovisual mirror neurons and action recognition. Exp Br Res. 2003;153:628-636.
4. Kohler E, Keysers C, Umiltà MA, Fogassi L, Gallese V, Rizzolatti G. Hearing sounds, understanding actions: action representation in mirror neurons. Science. 2002;297:846-848.
5. Rizzolatti G, Craighero L. The mirror-neuron system. Annu Rev Neurosci. 2004;27:169-192.
6. Fogassi L, Ferrari PF, Gesierich B, Rozzi S, Chersi F, Rizzolatti G. Parietal lobe: from action organization to intention understanding. Science. 2005;308:662-667.
7. Rozzi S, Ferrari PF, Bonini L, Rizzolatti G, Fogassi L. Functional organization of inferior parietal lobule convexity in the macaque monkey: electrophysiological characterization of motor, sensory and mirror responses and their correlation with cytoarchitectonic areas. Eur J Neurosci. 2008;28:1569-1588.
8. Chong TT-J, Cunnington R, Williams MA, Kanwisher N, Mattingley JB. fMRI adaptation reveals mirror neurons in human inferior parietal cortex. Curr Biol. 2008;18:1576-1580.
9. Gazzola V, Aziz-Zadeh L, Keysers C. Empathy and the somatotopic auditory mirror system in humans. Curr Biol. 2006;16:1824-1829.
10. Gazzola V, Keysers C. The observation and execution of actions share motor and somatosensory voxels in all tested subjects: single-subject analyses of unsmoothed fMRI data. Cereb Cortex. 2009;19:1239-1255.
11. Gazzola V, Rizzolatti G, Wicker B, Keysers C. The anthropomorphic brain: the mirror neuron system responds to human and robotic actions. Neuroimage. 2007;35:1674-1684.
12. Hamilton AFdC, Grafton ST. Action outcomes are represented in human inferior frontoparietal cortex. Cereb Cortex. 2008;18:1160-1168.
13. Iacoboni M, Woods RP, Brass M, Bekkering H, Mazziotta JC, Rizzolatti G. Cortical mechanisms of human imitation. Science. 1999;286:2526-2528.
14. Keysers C. Mirror neurons. Curr Biol. 2009;19:R971-R973.
15. Keysers C, Kaas JH, Gazzola V. Somatosensation in social perception. Nat Rev Neurosci. 2010;11:417-428.
16. Singer T, Lamm C. The social neuroscience of empathy. Ann N Y Acad Sci. 2009;1156:81-96.
17. Blakemore S-J, Bristow D, Bird G, Frith C, Ward J. Somatosensory activations during the observation of touch and a case of vision-touch synaesthesia. Brain. 2005;128(Pt 7):1571-1583.
18. Bufalari I, Aprile T, Avenanti A, Di Russo F, Aglioti SM. Empathy for pain and touch in the human somatosensory cortex. Cereb Cortex. 2007;17:2553-2561.
19. Ebisch SJH, Perrucci MG, Ferretti A, Del Gratta C, Romani GL, Gallese V. The sense of touch: embodied simulation in a visuotactile mirroring mechanism for observed animate or inanimate touch. J Cogn Neurosci. 2008;20:1611-1123.
20. Keysers C, Wicker B, Gazzola V, Anton J-L, Fogassi L, Gallese V. A touching sight: SII/PV activation during the observation and experience of touch. Neuron. 2004;42:335-346.
21. Schaefer M, Xu B, Flor H, Cohen LG. Effects of different viewing perspectives on somatosensory activations during observation of touch. Hum Brain Map. 2009;30:2722-2730.
22. De Renzi E, Cavalleri F, Facchini S. Imitation and utilisation behaviour. J Neurol Neurosurg Psychiatr. 1996;61:396-400.
23. Lhermitte F. 'Utilization behaviour' and its relation to lesions of the frontal lobes. Brain. 1983;106(Pt 2):237-255.
24. Lhermitte F, Pillon B, Serdaru M. Human autonomy and the frontal lobes. Part I: Imitation and utilization behavior: a neuropsychological study of 75 patients. Ann Neurol. 1986;19:326-334.
25. Banissy MJ, Cohen Kadosh R, Maus GW, Walsh V, Ward J. Prevalence, characteristics and a neurocognitive model of mirror-touch synaesthesia. Exp Br Res. 2009;198:261-272.
26. Banissy MJ, Ward J. Mirror-touch synesthesia is linked with empathy. Nat Neurosci. 2007;10:815-816.
27. Bastiaansen JACJ, Thioux M, Keysers C. Evidence for mirror systems in emotions. Philos Trans R Soc Lond, B, Biol Sci. 2009;364:2391-2404.
28. Wicker B, Keysers C, Plailly J, Royet JP, Gallese V, Rizzolatti G. Both of us disgusted in My insula: the common neural basis of seeing and feeling disgust. Neuron. 2003;40:655-664.
29. Jabbi M, Swart M, Keysers C. Empathy for positive and negative emotions in the gustatory cortex. Neuroimage. 2007;34:1744-1753.
30. Jabbi M, Keysers C. Inferior frontal gyrus activity triggers anterior insula response to emotional facial expressions. Emotion (Washington, DC). 2008;8:775-780.
31. Carr L, Iacoboni M, Dubeau M-C, Mazziotta JC, Lenzi GL. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci U S A. 2003;100:5497-5502.
32. van der Gaag C, Minderaa RB, Keysers C. Facial expressions: what the mirror neuron system can and cannot tell us. Soc Neurosci. 2007;2:179-222.
33. Cheng Y, Lin C-P, Liu H-L, et al. Expertise modulates the perception of pain in others. Curr Biol. 2007;17:1708-1713.
34. Costantini M, Galati G, Romani GL, Aglioti SM. Empathic neural reactivity to noxious stimuli delivered to body parts and non-corporeal objects. Eur J Neurosci. 2008;28:1222-1230.
35. Jackson PL, Brunet E, Meltzoff AN, Decety J. Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain. Neuropsychologia. 2006;44:752-761.
36. Jackson PL, Meltzoff AN, Decety J. How do we perceive the pain of others? A window into the neural processes involved in empathy. Neuroimage. 2005;24:771-779.
37. Lamm C, Meltzoff AN, Decety J. How do we empathize with someone who is not like us? A functional magnetic resonance imaging study. J Cogn Neurosci. 2010;22:362-376.
38. Lamm C, Nusbaum HC, Meltzoff AN, Decety J. What are you feeling? Using functional magnetic resonance imaging to assess the modulation of sensory and affective responses during empathy for pain. PLoS ONE. 2007;2:e1292.
39. Morrison I, Peelen MV, Downing PE. The sight of others' pain modulates motor processing in human cingulate cortex. Cereb Cortex. 2007;17:2214-2222.
40. Lamm C, Batson CD, Decety J. The neural substrate of human empathy: effects of perspective-taking and cognitive appraisal. J Cogn Neurosci. 2007;19:42-58.
41. Saarela MV, Hlushchuk Y, Williams ACdC, Schürmann M, Kalso E, Hari R. The compassionate brain: humans detect intensity of pain from another's face. Cereb Cortex. 2007;17:230-237.
42. Singer T. The neuronal basis and ontogeny of empathy and mind reading: review of literature and implications for future research. Neurosci Biobehav Rev. 2006;30:855-863.
43. Singer T, Seymour B, O'Doherty J, Kaube H, Dolan RJ, Frith CD. Empathy for pain involves the affective but not sensory components of pain. Science. 2004;303:1157-1162.
44. Davis MH. Measuring individual differences in empathy: Evidence for a multidimensional approach. J Person Soc Psychol. 1983;44:113-126.
45. Adolphs R. How do we know the minds of others? Domain-specificity, simulation, and enactive social cognition. Brain Res. 2006;1079:25-35.
46. Gallese V, Keysers C, Rizzolatti G. A unifying view of the basis of social cognition. Trends Cogn Sci (Regul Ed). 2004;8:396-403.
47. Iacoboni M. Imitation, empathy, and mirror neurons. Annu Rev Psychol. 2009;60:653-670.
48. Keysers C, Gazzola V. Towards a unifying neural theory of social cognition. Prog Brain Res. 2006;156:379-401.
49. Keysers C, Gazzola V. Expanding the mirror: vicarious activity for actions, emotions, and sensations. Curr Opin Neurobiol. 2009;19:666-671.
50. Singer T, Seymour B, O'Doherty JP, Stephan KE, Dolan RJ, Frith CD. Empathic neural responses are modulated by the perceived fairness of others. Nature. 2006;439:466-469.
51. Avikainen S, Kulomäki T, Hari R. Normal movement reading in Asperger subjects. Neuroreport. 1999;10:3467-3470.
52. Bird G, Leighton J, Press C, Heyes C. Intact automatic imitation of human and robot actions in autism spectrum disorders. Proc Biol Sci. 2007;274:3027-3031.
53. Oberman LM, Ramachandran VS, Pineda JA. Modulation of mu suppression in children with autism spectrum disorders in response to familiar or unfamiliar stimuli: the mirror neuron hypothesis. Neuropsychologia. 2008;46:1558-1565.
54. Carpenter M, Pennington BF, Rogers SJ. Understanding of others' intentions in children with autism. J Autism Dev Disord. 2001;31:589-599.
55. Hamilton AFdC, Brindley RM, Frith U. Imitation and action understanding in autistic spectrum disorders: how valid is the hypothesis of a deficit in the mirror neuron system? Neuropsychologia. 2007;45:1859-1868.
56. Dapretto M, Davies MS, Pfeifer JH, et al. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci. 2006;9:28-30.
57. Bookheimer SY, Wang AT, Scott A, Sigman M, Dapretto M. Frontal contributions to face processing differences in autism: evidence from fMRI of inverted face processing. J Int Neuropsychol Soc. 2008;14:922-932.
58. Uddin LQ, Davies MS, Scott AA, et al. Neural basis of self and other representation in autism: an FMRI study of self-face recognition. PLoS ONE. 2008;3:e3526.
59. Ashwin C, Baron-Cohen S, Wheelwright S, O'Riordan M, Bullmore ET. Differential activation of the amygdala and the 'social brain' during fearful face-processing in Asperger Syndrome. Neuropsychologia. 2007;45:2-14.
60. Pierce K, Haist F, Sedaghat F, Courchesne E. The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain. 2004;127(Pt 12):2703-2716.
61. Hadjikhani N, Joseph RM, Snyder J, Tager-Flusberg H. Abnormal activation of the social brain during face perception in autism. Hum Brain Map. 2007;28:441-449.
62. Baron-Cohen S, Knickmeyer RC, Belmonte MK. Sex differences in the brain: implications for explaining autism. Science. 2005;310:819-823.
63. Beall PM, Moody EJ, McIntosh DN, Hepburn SL, Reed CL. Rapid facial reactions to emotional facial expressions in typically developing children and children with autism spectrum disorder. J Exp Child Psychol. 2008;101:206-223.