The application of MRI for depiction of subtle blood brain barrier disruption in stroke

International Journal of Biological Sciences

Volumn 7, Issue 1, 2011, Pages 1-8

  Israeli, David ^a   Tanne, David ^b,c   Daniels, Dianne ^b   Last, David ^b   Shneor, Ran ^b   Guez, David ^b   Landau, Efrat ^b   Roth, Yiftach ^b   Ocherashvilli, Aharon ^b   Bakon, Mati ^b   Hoffman, Chen ^b,c   Weinberg, Amit ^b   Volk, Talila ^a   Mardor, Yael ^b,c  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Brain; Delayed enhancement; MRI; Stroke; Subtle BBB disruption

Indexed keywords

EID: 79952467007     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.7.1     Document Type: Article

References (25)

1. Roberts HC, Roberts TP, Brasch RC, Dillon WP. Quantitative measurement of microvascular permeability in human brain tumors achieved using DCE MR imaging: correlation with histologic grade. Am J Neuroradiol. 2000; 21: 891-899.
2. Cao Y, Shen Z, Chenevert TL, Ewing JR. Estimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T2*-weighted MRI. J Magn Res Imag. 2006; 24: 288-296.
3. Starr JM, Wardlaw J, Ferguson K, et al. Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging. J Neurol Neurosurg Psychiatry. 2003; 74: 70-76.
4. Knopp EA, Cha S, Johnson G et al. Glial neoplasms: DCE T2*-weighted MR imaging. Radiology. 1999; 211: 791-798.
5. Patankar TF, Haroon HA, Mills SJ et al. Is volume transfer coefficient (K(trans)) related to histologic grade in human gliomas? Am J Neuroradiol. 2005; 26: 2455-2465.
6. Starr JM, Farrall AJ, Armitageb P et al. Blood-brain barrier permeability in Alzheimer's disease: a case-control MRI study. Neuroimag. 2009; 171: 232-241.
7. Tomkins O, Shelef I, Kaizerman I et al. Blood-brain barrier disruption in post-traumatic Epilepsy. J Neurol Neurosurg Psychiatry. 2008; 79: 774-777.
8. Yang S, Law M, Zagzag D et al. DCE perfusion MR imaging measurements of endothelial permeability: Differentiation between atypical and typical meningiomas. Am J Neuroradiol. 2003; 24: 1554-1559.
9. Hjort N, Wu O, Ashkanian M et al. MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal HT after thrombolysis. Stroke. 2008; 39: 1025-8.
10. Ding G, Jiang Q, Li L et al. Detection of BBB disruption and hemorrhage by Gd-DTPA enhanced MRI after embolic stroke in rat. Brain Res. 2006; 1114: 195-203.
11. Ewing JR, Knight RA, Nagaraja TN et al. Patlak plots of Gd-DTPA MRI data yield blood-brain transfer constants concordant with those of 14C-sucrose in areas of blood-brain opening. Magn Res in Med. 2003; 50: 283-292.
12. Jiang Q, Ewing JR, Ding GL et al. Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI. J Cereb Blood Flow Metab. 2005; 25: 583-92.
13. Knight RA, Karki K, Ewing JR et al. Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[(14)C]DTPA. J Cereb Blood Flow Metab. 2009; 29: 1048-58.
14. Nagaraja TN, Karki K, Ewing JR et al. Identification of variations in blood-brain barrier opening after cerebral ischemia by dual contrast-enhanced magnetic resonance imaging and T 1sat measurements. Stroke. 2008; 39: 427-32.
15. Neumann-Haefelin T, Kastrup A, de Crespigny A et al. Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke. 2000; 31: 1965-72.
16. Pillai DR, Dittmar MS, Baldaranov D et al. Cerebral ischemia-reperfusion injury in rats-A 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formation. J Cereb Blood Flow Metab. 2009; 29(11):1846-55.
17. Taheri S, Sood R. Partial volume effect compensation for improved reliability of quantitative blood-brain barrier permeability. Magn Reson Imaging. 2007; 25: 613-25.
18. Latour LL, Kang DW, Ezzeddine MA, Chalela JA, Warach S. Early blood-brain barrier disruption in human focal brain ischemia. Ann Neurol. 2004; 56: 468-477.
19. Ning M, Furie KL, Koroshetz WJ et al. Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke. Neurology. 2006; 66: 1550-5.
20. Warach S, Latour LL. Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption. Stroke. 2004; 35(11 Suppl 1): 2659-2661.
21. Kassner A, Roberts T, Taylor K, Silver F, Mikulis D. Prediction of hemorrhage in acute ischemic stroke using permeability MR imaging. Am J Neuroradiol. 2005; 26: 2213-2217.
22. Bang OY, Buck BH, Saver JL, et al. Prediction of HT after recanalization therapy using T2*- permeability magnetic resonance imaging. Ann Neurol. 2007; 62: 170-176.
23. Bang OY, Saver JL, Alger JR, et al. Patterns and predictors of blood-brain barrier permeability derangements in acute ischemic stroke. Stroke. 2009; 40: 454-461.
24. Rosenberg GA. Inflammation and white matter damage in vascular cognitive impairment. Stroke. 2009; 40: s20-s23.
25. Lüdemann L, Grieger W, Wurm R, Wust P, Zimmer C. Quantitative measurement of leakage volume and permeability in gliomas, meningiomas and brain metastases with DCE MRI. Magn Reson Imaging. 2005; 23: 833-841.