Chronic cadmium toxicity in rats: Treatment with combined administration of vitamins, amino acids, antioxidants and essential metals

Journal of Food and Drug Analysis

Volumn 18, Issue 6, 2010, Pages 464-470

  Gaurav, Deepti ^a   Preet, Shabad ^a   Dua, K K ^a  

^a DAYALBAGH EDUCATIONAL INSTITUTE   (India)

Author keywords

Antioxidant defense system; Cadmium; Dietary nutrients; Lipid peroxidation; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; AMINO ACID; ANTIOXIDANT; CADMIUM; CADMIUM CHLORIDE; CYSTINE; GLUTATHIONE PEROXIDASE; MELATONIN; METAL; METHIONINE; PROTEIN; SELENIUM; SUPEROXIDE DISMUTASE; THIAMINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; VITAMIN; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CADMIUM POISONING; CONTROLLED STUDY; DIETARY INTAKE; ENZYME ACTIVITY; KIDNEY MASS; LIPID PEROXIDATION; LIVER PROTECTION; LIVER TOXICITY; LIVER WEIGHT; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; RENAL PROTECTION;

ANIMALIA; RATTUS;

EID: 79952458034     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Sarkar, S., Yadav, P., Trivedi, R, Bansal, A. K. and Bhatnagar, D. 1995. Cadmium induced lipid peroxidation and status of antioxidant system in rats' tissues. J. Trace. Elem. Med. Biol. 9: 144-149.
2. Casalino, E., Calzaretti, G., Sblano, C. and Landriscina, C. 2002. Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicol. 30: 37-50. (Pubitemid 35245462)
3. Shaikh, Z. A., Vu, T. T. and Zaman, K. 1999. Oxidative stress as a mechanism of chronic cadmium- induced hepatotoxicity and renal toxicity and protection by anti-oxidants. Toxicol. Appl. Pharmacol. 154: 256-263.
4. Casalino, E, Sblano, C. and Landriscina, C. 1997. Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch. Biochem. Biophys. 346: 171-179.
5. El-Missiry, M. A. and Shalaby, F. 2000. Role of β-carotene in ameliorating the cadmium induced oxidative stress in rat brain and testis. J. Biochem. Mol. Toxicol. 14: 238-243.
6. Rana, S. V. S. and Verma, S. 1996. Protective effects of GSH, vitamin E and selenium on lipid peroxidation in cadmium-fed rats. Biol. Trace Elem. Res. 51: 161-168.
7. Newairy, A. A., El-Sharaky, A. S., Badreldeen, M. M., Eweda, S. M. and Sheweita, S. A. 2007. The hepatoprotective effects of selenium against cadmium toxicity in rats. Toxicol. 242: 23-30.
8. Burk, R. F. 2002. Selenium as antioxidant nutrient. Nutr. Clin. Care 5: 75-79.
9. Ognjanovic, B. I., Markovic, S. D., Pavlovic, S. Z., Zikic, R. V., Stajn, A. S. and Saicic, Z. S. 2008. Effect of chronic cadmium exposed on antioxidant defense system in some tissue of rats: protective effect of selenium. Physiol. Res. 57: 403-411.
10. Beytut, E., Yuce, A., Kamiloglu, N. N. and Aksakal, M. 2003. Role of dietary vitamin E in cadmium-induced oxidative damage in rabbit's blood, liver and kidneys. Int. J. Vitam. Nutr. Res. 73: 351-355.
11. Flora S. J. S., Mittal M. and Mehta A. 2008. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J. Med. Res. 128: 501-523.
12. Gupta, R., Kannan, G. M., Sharma, M. and Flora, S. J. A. 2005. Therapeutic effects of Moringa oleifera on arsenic-induced toxicity in rats. Environ. Toxicol. Pharmacol. 20: 456-464.
13. Shirley, R.L., Beune, W. J. and Miller, E.J. 1949. Cadmium in biological material and food. Anal. Chem. 21: 300-303.
14. Onkawa, H., Oshishi, N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351-358.
15. Kakkar, P, Das, B. and Viswanathan, P. A. 1984. A modified spectro-photometric assay of superoxide dismutase. Indian J. Biochem. Biophys. 21: 130-132.
16. Flohe, L. and Gunzler, W. A. 1984. Assays of glutathione peroxidase. Meth. Enzymol. 105: 114-121.
17. th ed. pp. 1123. McGraw Hill. New York, U.S.A.
18. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Ramdall, R. J. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275.
19. Stohs, S. J., Bagchi, D., Hassoun, E. and Bagchi, M. 2001. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J. Environ. Pathol. Toxicol. Oncol. 20: 77-88.
20. Flora, S. J. S. 2007. Role of free radicals and antioxidants in health and disease. Cell. Mol. Biol. 53: 1-24.
21. Anane, R. and Creppy, E. E. 2001. Lipid peroxidation as pathway of aluminum cytotoxicity in human skin fibroblast cultures: prevention by superoxide dismutase + catalase and vitamins E and vitamin C. Hum. Exp. Toxicol. 20: 477-481.
22. Juruczuk, M. M., Brzoska, J., Moniuszka-Jakoniuk, M., Galazyn-Sidorzuk, E. and Eulikowska-Karpiska. 2004. Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food. Chem. Toxicol. 42: 429-438.
23. Flora, S. J. S., Mehta, A. and Gupta, R. 2009. Prevention of arsenic induced hepatic apoptosis by concomitant administration of garlic extraction in mice. Chem. Biol. Interact. 177: 227-233.
24. Tan, D. X., Reiter, R. J., Manchester, L. C., Yan, M. T., El-Sawi, M, Sainz, R. M., Mayo, J. C., Kohen, R., Allegra, M. and Hardeland, R. 2002. Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr. Top. Med. Chem. 2: 181-197.
25. Chwelatiuk, E., Wlostowski, T., Krasowska, A. and Bonda, E. 2006. The effect of orally administered melatonin on tissue accumulation and toxicity of cadmium in mice. J. Trace Elem. Med. Biol. 19: 259-265.
26. Fotakis, G. and Timbrell, J. A. 2006. Sulfur amino acid deprivation in cadmium chloride toxicity in hepatoma cells. Environ Toxicol. Pharmacol. 22: 334-337.
27. Jacquillet, G., Barbier, O., Cougnon, M., Tauc, M., Namorado, M. C., Martin, D., Reyes, J. L. and Poujeol, P. 2006. Zinc protects renal function during cadmium intoxication in the rats. Am. J. Physiol. Renal Physiol. 290: 127-137.
28. Konar, V., Kara, H., Yilmaz, M., Dayangac, A. and Karatas, F. 2007. Effect of selenium and Vitamin E in addition to melatonin, against oxidative stress caused by cadmium in rats. Biol. Trace Elem. Res. 118: 131-137.