Validated LC-MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma

Bioanalysis

Volumn 2, Issue 12, 2010, Pages 2001-2009

  Aubry, Anne Françoise ^a   Gu, Huidong ^a   Magnier, Reynald ^b   Morgan, Ling ^c   Xu, Xiaohui ^a   Tirmenstein, Mark ^a   Wang, Bonnie ^a   Deng, Yuzhong ^a,d   Cai, Jinnan ^a,e   Couerbe, Philippe ^b   Arnold, Mark ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b SOLVO BIOTECHNOLOGY   (Hungary)

^c Tandems Labs New England   (United States)

^d GENENTECH INC   (United States)

^e ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DAPAGLIFLOZIN; 2 (3 (4 ETHOXYBENZYL) 4 CHLOROPHENYL) 6 HYDROXYMETHYLTETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2-(3-(4-ETHOXYBENZYL)-4-CHLOROPHENYL)-6-HYDROXYMETHYLTETRAHYDRO-2H-PYRAN-3,4,5-TRIOL; ACETONITRILE; ACETONITRILE DERIVATIVE; ENZYME INHIBITOR; GLUCOSIDE; SODIUM GLUCOSE COTRANSPORTER 2; WATER;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG RETENTION; DRUG SPECIFICITY; DRUG STABILITY; DRUG STRUCTURE; ELUTION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NEGATIVE ION ELECTROSPRAY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; POSITIVE ION ELECTROSPRAY; RAT; SOLID PHASE EXTRACTION; TOXICITY TESTING; VALIDATION PROCESS; ANIMAL; BLOOD; CHEMISTRY; DISEASE MODEL; DRUG ANTAGONISM; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; ZUCKER RAT;

ACETONITRILES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GLUCOSIDES; MASS SPECTROMETRY; RATS; RATS, ZUCKER; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SODIUM-GLUCOSE TRANSPORTER 2; SOLID PHASE EXTRACTION; WATER;

EID: 79952456216     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.10.139     Document Type: Article

References (10)

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