Frozen human cells can record radiation damage accumulated during space flight: Mutation induction and radioadaptation

Radiation and Environmental Biophysics

Volumn 50, Issue 1, 2011, Pages 125-134

  Yatagai, Fumio ^a   Honma, Masamitsu ^b   Takahashi, Akihisa ^d   Omori, Katsunori ^c   Suzuki, Hiromi ^e   Shimazu, Toru ^e   Seki, Masaya ^f   Hashizume, Toko ^f   Ukai, Akiko ^b   Sugasawa, Kaoru ^g   Abe, Tomoko ^a   Dohmae, Naoshi ^a   Enomoto, Shuichi ^a   Ohnishi, Takeo ^d   Gordon, Alasdair ^h   Ishioka, Noriaki ^c  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c JAPAN AEROSPACE EXPLORATION AGENCY   (Japan)

^d NARA MEDICAL UNIVERSITY   (Japan)

^e Japan Space Forum ^*  (Japan)

^f Co Ltd   (Japan)

^g KOBE UNIVERSITY   (Japan)

^h BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ASSAYS; CELLULAR RESPONSE; CONTROL LEVEL; CONTROL SAMPLES; DNA DAMAGES; DOUBLE STRAND BREAK REPAIR; ENVIRONMENTAL EFFECTS; GROUND CONTROL; HETEROZYGOSITY; HIGHER EFFICIENCY; HOMOLOGOUS RECOMBINATION; HUMAN CELLS; INTERNATIONAL SPACE STATIONS; LOW DOSE; MUTATION FREQUENCY; MUTATION INDUCTION; NONHOMOLOGOUS END JOINING; SPACE RADIATIONS; THYMIDINE KINASE;

ION BEAMS; MANNED SPACE FLIGHT; NUCLEIC ACIDS; RADIATION; RADIATION DAMAGE; ROCK MECHANICS; SPACE SHUTTLES; SPACE STATIONS;

EARTH (PLANET);

THYMIDINE KINASE; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ADAPTATION; ARTICLE; CELL LINE; CRYOPRESERVATION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENVIRONMENTAL EXPOSURE; ENZYMOLOGY; GENE VECTOR; GENETICS; HUMAN; LYMPHOCYTE; METABOLISM; METHODOLOGY; MUTATION; PATHOLOGY; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE; RADIOMETRY; SPACE FLIGHT; X RAY;

ADAPTATION, PHYSIOLOGICAL; CELL LINE; CRYOPRESERVATION; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENVIRONMENTAL EXPOSURE; GENETIC VECTORS; HUMANS; LYMPHOCYTES; MUTATION; RADIATION INJURIES; RADIOMETRY; SPACE FLIGHT; THYMIDINE KINASE; X-RAYS;

EID: 79952454745     PISSN: 0301634X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00411-010-0348-3     Document Type: Article

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