Pharmacokinetics of single-dose intravenous ketorolac in infants aged 2-11 months

Anesthesia and Analgesia

Volumn 112, Issue 3, 2011, Pages 655-660

  Cohen, Mindy N ^a   Christians, Uwe ^b   Henthorn, Thomas ^b   Vu Tran, Zung ^c   Moll, Vanessa ^b   Zuk, Jeannie ^a   Galinkin, Jeffrey ^a  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETOROLAC;

AGE; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; ELECTIVE SURGERY; HUMAN; INFANT; PRIORITY JOURNAL; SINGLE DRUG DOSE; STEADY STATE;

EID: 79952453321     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3182075d04     Document Type: Article

References (32)

1. Gillies GW, Kenny GN, Bullingham RE, McArdle CS. The morphine sparing effect of ketorolac tromethamine: a study of a new, parenteral non-steroidal anti-inflammatory agent after abdominal surgery. Anaesthesia 1987;42:727-31
2. Power I, Douglas E. The nonsteroidal anti-inflammatory anal-gesics. NATNEWS 1989;26:14-5
3. Rooks WH II, Maloney PJ, Shott LD, Schuler ME, Sevelius H, Strosberg AM, Tanenbaum L, Tomolonis AJ, Wallach MB, Waterbury D, Yee J. The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt. Drugs Exp Clin Res 1985;11:479-92 (Pubitemid 15228598)
4. Bravo LJ, Mattie H, Spierdijk J, Bovill JG, Burm AG. The effects on ventilation of ketorolac in comparison with morphine. Eur J Clin Pharmacol 1988;35:491-4 (Pubitemid 18264752)
5. Murray AW, Brockway MS, Kenny GN. Comparison of the cardiorespiratory effects of ketorolac and alfentanil during propofol anaesthesia. Br J Anaesth 1989;63:601-3 (Pubitemid 19285670)
6. Brown CR, Moodie JE, Wild VM, Bynum LJ. Comparison of intravenous ketorolac tromethamine and morphine sulfate in the treatment of postoperative pain. Pharmacotherapy 1990;10:116S-21S
7. Peirce RJ, Fragen RJ, Pemberton DM. Intravenous ketorolac tromethamine versus morphine sulfate in the treatment of imme-diate postoperative pain. Pharmacotherapy 1990;10:111S-5S
8. Bosek V, Smith DB, Cox C. Ketorolac or fentanyl to supplement local anesthesia? J Clin Anesth 1992;4:480-3 (Pubitemid 23010339)
9. Ramirez-Ruiz M, Smith I, White PF. Use of analgesics during propofol sedation: a comparison of ketorolac, dezocine, and fentanyl. J Clin Anesth 1995;7:481-5
10. Mroszczak EJ, Jung D, Yee J, Bynum L, Sevelius H, Massey I. Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals. Pharmacotherapy 1990;10:33S-9S
11. Hamunen K, Maunuksela EL, Sarvela J, Bullingham RE, Olkkola KT. Stereoselective pharmacokinetics of ketorolac in children, adolescents and adults. Acta Anaesthesiol Scand 1999;43:1041-6 (Pubitemid 29529818)
12. Kauffman RE, Lieh-Lai MW, Uy HG, Aravind MK. Enantiomer-selective pharmacokinetics and metabolism of ke-torolac in children. Clin Pharmacol Ther 1999;65:382-8 (Pubitemid 29196540)
13. Lynn AM, Bradford H, Kantor ED, Seng KY, Salinger DH, Chen J, Ellenbogen RG, Vicini P, Anderson GD. Postoperative ketorolac tromethamine use in infants aged 6-18 months: the effect on morphine usage, safety assessment, and stereo-specific pharmacokinetics. Anesth Analg 2007;104:1040-51 (Pubitemid 46649920)
14. Jung D, Mroszczak E, Bynum L. Pharmacokinetics of ketorolac tromethamine in humans after intravenous, intramuscular and oral administration. Eur J Clin Pharmacol 1988;35:423-5
15. Olkkola KT, Maunuksela EL. The pharmacokinetics of postop-erative intravenous ketorolac tromethamine in children. Br J Clin Pharmacol 1991;31:182-4
16. Dsida RM, Wheeler M, Birmingham PK, Wang Z, Heffner CL, Cote CJ, Avram MJ. Age-stratified pharmacokinetics of ketoro-lac tromethamine in pediatric surgical patients. Anesth Analg 2002;94:266-70 (Pubitemid 34106813)
17. Gonzalez-Martin G, Maggio L, Gonzalez-Sotomayor J, Zuniga S. Pharmacokinetics of ketorolac in children after abdominal surgery. Int J Clin Pharmacol Ther 1997;35:160-3 (Pubitemid 27156752)
18. Zuppa AF, Mondick JT, Davis L, Cohen D. Population phar-macokinetics of ketorolac in neonates and young infants. Am J Ther 2009;16:143-6
19. Mroszczak EJ, Lee FW, Combs D, Sarnquist FH, Huang BL, Wu AT, Tokes LG, Maddox ML, Cho DK. Ketorolac tromethamine absorption, distribution, metabolism, excretion, and pharma-cokinetics in animals and humans. Drug Metab Dispos 1987;15:618-26 (Pubitemid 18004616)
20. Jung D, Mroszczak EJ, Wu A, Ling TL, Sevelius H, Bynum L. Pharmacokinetics of ketorolac and p-hydroxyketorolac follow-ing oral and intramuscular administration of ketorolac tromethamine. Pharm Res 1989;6:62-5 (Pubitemid 19060825)
21. Jallad NS, Garg DC, Martinez JJ, Mroszczak EJ, Weidler DJ. Pharmacokinetics of single-dose oral and intramuscular ketorolac tromethamine in the young and elderly. J Clin Pharmacol 1990;30:76-81 (Pubitemid 20072729)
22. Lynn AM, Nespeca MK, Bratton SL, Shen DD. Ventilatory effects of morphine infusions in cyanotic versus acyanotic infants after thoracotomy. Paediatr Anaesth 2003;13:12-7 (Pubitemid 36114994)
23. Clavijo C, Strom T, Moll V, Betts R, Zhang YL, Christians U, Bendrick-Peart J. Development and validation of a semi-automated assay for the highly sensitive quantification of Biolimus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry. J Chro-matogr B Analyt Technol Biomed Life Sci 2009;877:3506-14
24. Clavijo C, Bendrick-Peart J, Zhang YL, Johnson G, Gasparic A, Christians U. An automated, highly sensitive LC-MS/MS assay for the quantification of the opiate antagonist naltrexone and its major metabolite 6beta-naltrexol in dog and human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2008;874:33-41
25. Müller C, Schäfer P, Störtzel M, Vogt S, Weinmann W. Ion suppression effects in liquid chromatography-electrospray-ionisation transport-region collision induced dissociation mass spectrometry with different serum extraction methods for systematic toxicological analysis with mass spectra libraries. J Chromatogr B Analyt Technol Biomed Life Sci 2002;773:47-52 (Pubitemid 34518269)
26. Cobelli C, Foster DM. Compartmental models: theory and practice using the SAAM II software system. Adv Exp Med Biol 1998;445:79-101 (Pubitemid 28391767)
27. Foster DM. Developing and testing integrated multicompart-ment models to describe a single-input multiple-output study using the SAAM II software system. Adv Exp Med Biol 1998;445:59-78 (Pubitemid 28391766)
28. Mandema JW, Stanski DR. Population pharmacodynamic model for ketorolac analgesia. Clin Pharmacol Ther 1996;60:619-35 (Pubitemid 27025909)
29. Feldman HI, Kinman JL, Berlin JA, Hennessy S, Kimmel SE, Farrar J, Carson JL, Strom BL. Parenteral ketorolac: the risk for acute renal failure. Ann Intern Med 1997;126:193-9 (Pubitemid 27061572)
30. Kallanagowdar C, LeBreton A, Aviles DH. Acute renal failure. Clin Pediatr (Phila) 2006;45:771-3 (Pubitemid 44359199)
31. Buck ML, Norwood VF. Ketorolac-induced acute renal failure in a previously healthy adolescent. Pediatrics 1996;98:294-6 (Pubitemid 26262147)
32. Simckes AM, Chen SS, Osorio AV, Garola RE, Woods GM. Ketorolac-induced irreversible renal failure in sickle cell dis-ease: a case report. Pediatr Nephrol 1999;13:63-7 (Pubitemid 29206262)