Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ1 and σ2 receptors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 6, 2011, Pages 1852-1859

  Fan, Kuo Hsien ^a   Lever, John R ^b,c   Lever, Susan Z ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Aminobutyl benzamides; Sigma receptors; Structure activity relationships

Indexed keywords

(7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H BENZO[B]AZEPIN 1 YL)BUTAN 1 AMINE; 2 (4 AZIDOBUTYL) 5,6 DIMETHOXYISOINDOLINE; 4 (2,3 DIMETHOXYPHENETHYLAMINO)BUTANENITRILE; 4 (5,6 DIMETHOXYINDOLIN 1 YL)BUTAN 1 AMINE; 4 (5,6 DIMETHOXYISOINDOLIN 2 YL)BUTAN 1 AMINE; 4 (6,7 DIMETHOXY 3,4 DIHYDROQUINOLIN 1 (2H) YL)BUTAN 1 AMINE; 4 (7,8 DIMETHOXY 4,5 DIHYDRO 1H BENZO[C]AZAPIN 3(2H) YL)BUTAN 1 AMINE; 4 (7,8 DIMETHOXY 4,5 DIHYDRO 1H BENZO[D]AZAPIN 3(2H) YL)BUTAN 1 AMINE; 5 BROMO N [4 (5,6 DIMETHOXYINDOLIN 1 YL)BUTYL] 2,3 DIMETHOXYBENZAMIDE; 5 BROMO N [4 (5,6 DIMETHOXYISOINDOLIN 2 YL)BUTYL] 2,3 DIMETHOXYBENZAMIDE; 5 BROMO N [4 (6,7 DIMETHOXY 3,4 DIHYDROQUINOLIN 1(2H) YL)BUTYL] 2,3 DIMETHOXYBENZAMIDE; 5 BROMO N [4 (7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H BENZO[B]AZEPIN 1 YL)BUTYL] 2,3 DIMETHOXYBENZAMIDE; 5 BROMO N [4 (7,8 DIMETHOXY 4,5 DIHYDRO 1H BENZO[C]AZEPIN 2 (3H) YL)BUTYL] 2,3 DIMETHOXYBENZAMIDE; 5 BROMO N [4 (7,8 DIMETHOXY 4,5 DIHYDRO 1H BENZO[D]AZEPIN 3 (2H) YL)BUTYL] 2,3 DIMETHOXYBENZAMIDE; 5 BROMO N [4 [(3,4 DIMETHOXYPHENETHYL)(METHYL)AMINO]BUTYL] 2,3 DIMETHOXYBENZAMIDE; 5 BROMO N [4(6,7 DIMETHOXY 3,4 DIHYDRO 1H ISOQUINOLIN 2 YL)] 2,3 DIMETHOXY BENZAMIDE; 5,6 DIMETHOXYINDOLINE; 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROQUINOLINE; 7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H BENZO[B]AZEPIN; 7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H BENZO[C]AZEPIN 1 ONE; 7,8 DIMETHOXY 4,5 DIHYDRO 1H BENZO[C]AZEPIN 2(3H) ONE; AMINE; AMINOBUTYL BENZAMIDE DERIVATIVE; N (3,4 DIMETHOXYPHENETHYL) N (3 CYANOPROPYL) FORMAMIDE; N (3,4 DIMETHOXYPHENETHYL) N METHYLBUTANE 1,4 DIAMINE; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; LIGAND BINDING; RECEPTOR BINDING; STRUCTURE ANALYSIS; SYNTHESIS;

AMINES; BENZAMIDES; ISOQUINOLINES; LIGANDS; PROTEIN BINDING; RECEPTORS, SIGMA;

EID: 79952442826     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.02.006     Document Type: Article

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