Hypoglycemia complicating bariatric surgery: Incidence and mechanisms

Current Opinion in Endocrinology, Diabetes and Obesity

Volumn 18, Issue 2, 2011, Pages 129-133

  Foster Schubert, Karen E ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

bariatric surgery; dumping syndrome; gastric bypass; hyperinsulinism; hypoglycemia; incretin; insulin sensitivity; obesity

Indexed keywords

ARTICLE; BARIATRIC SURGERY; CELL FUNCTION; CELL PROLIFERATION; DISEASE SEVERITY; HUMAN; HYPOGLYCEMIA; INCIDENCE; OBESITY; PANCREAS ISLET BETA CELL; POSTOPERATIVE COMPLICATION; RISK; STOMACH BYPASS;

BARIATRIC SURGERY; HUMANS; HYPOGLYCEMIA; INCIDENCE; PATIENT SELECTION; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 79952442346     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e32834449b9     Document Type: Article

References (37)

1. Balkau B, Deanfield JE, Despres JP, et al. International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries. Circulation 2007; 116:1942-1951. (Pubitemid 350287090)
2. Sturm R. Increases in morbid obesity inthe USA: 2000-2005. Public Health 2007; 121:492-496. (Pubitemid 46895458)
3. Foster-Schubert KE, Cummings DE. Emerging therapeutic strategies for obesity. Endocr Rev 2006; 27:779-793. (Pubitemid 44936060)
4. Cummings DE, Overduin J, Foster-Schubert KE. Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 2004; 89:2608-2615. (Pubitemid 38766339)
5. Buchwald H, Oien DM. Metabolic/bariatric surgery worldwide 2008. Obes Surg 2009; 19:1605-1611.
6. Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007; 357:741-752. (Pubitemid 47295641)
7. Service GJ, Thompson GB, Service FJ, et al. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med 2005; 353:249-254. (Pubitemid 41058324)
8. Patti ME, McMahon G, Mun EC, et al. Severe hypoglycaemia postgastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 2005; 48:2236-2240. (Pubitemid 41618912)
9. Cummings DE. Gastric bypass and nesidioblastosis: too much of a good thing for islets? N Engl J Med 2005; 353:300-302. (Pubitemid 41058331)
10. Clancy TE, Moore FD Jr, Zinner MJ. Postgastric bypass hyperinsulinism with nesidioblastosis: subtotal or total pancreatectomy may be needed to prevent recurrent hypoglycemia. J Gastrointest Surg 2006; 10:111 6-1119.
11. Alvarez GC, Faria EN, Beck M, et al. Laparoscopic spleen-preserving distal pancreatectomy as treatment for nesidioblastosis after gastric bypass sur-gery. Obes Surg 2007; 17:550-552. (Pubitemid 46850198)
12. Bantle JP, Ikramuddin S, Kellogg TA, Buchwald H. Hyperinsulinemic hypo-glycemia developing late after gastric bypass. Obes Surg 2007; 17:592-594. (Pubitemid 46945415)
13. Abellan P, Camara R, Merino-Torres JF, et al. Severe hypoglycemia after gastric bypass surgery for morbid obesity. Diabetes Res Clin Pract 2008; 79:e7-e9.
14. Kellogg TA, Bantle JP, Leslie DB, et al. Postgastric bypass hyperinsulinemic hypoglycemia syndrome: characterization and response to a modified diet. Surg Obes Relat Dis 2008; 4:492-499. (Pubitemid 352006166)
15. Z'Graggen K, Guweidhi A, Steffen R, et al. Severe recurrent hypoglycemia after gastric bypass surgery. Obes Surg 2008; 18:981-988.
16. Moreira RO, Moreira RB, Machado NA, et al. Postprandial hypoglycemiaafter bariatric surgery: pharmacological treatment with verapamil and acarbose. Obes Surg 2008; 18:1618-1621.
17. Spanakis E, Gragnoli C Successful medical management of status post-Roux-en-Y-gastric-bypass hyperinsulinemic hypoglycemia. Obes Surg 2009; 19:1333-1334.
18. Deitel M. The change in the dumping syndrome concept Obes Surg 2008; 18:1622-1624.
19. Tack J, Arts J, Caenepeel P, et al. Pathophysiology, diagnosis and manage-ment of postoperative dumping syndrome. Nat Rev Gastroenterol Hepatol 2009; 6:583-590.
20. Vella A, Service FJ. Incretin hypersecretion in postgastric bypass hypogly-cemia: primary problem or red herring? J Clin Endocrinol Metab 2007; 92:4563-4565. (Pubitemid 350223426)
21. Service FJ. Classification of hypoglycemic disorders. Endocrinol Metab Clin North Am 1999; 28:501-517; vi. (Pubitemid 29441319)
22. Lev-Ran A, Anderson RW. The diagnosis of postprandial hypoglycemia. Diabetes 1981; 30:996-999.
23. Scavini M, Pontiroli AE, Folli F. Asymptomatic hyperinsulinemic hypoglycemia after gastric banding. N Engl J Med 2005; 353:2822-2823. (Pubitemid 43016842)
24. Kim SH, Liu TC, Abbasi F, et al. Plasma glucose and insulin regulation is abnormal following gastric bypass surgery with or without neuroglycopenia. Obes Surg 2009; 19:1550-1556.
25. Goldfine AB, Mun EC, Devine E, et al. Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J Clin Endocrinol Metab 2007; 92:4678-4685. (Pubitemid 350223444)
26. Hanaire H, Dubet A, Chauveau ME, et al. Usefulness of continuous glucose monitoring forthe diagnosis of hypoglycemia after a gastric bypass in a patient previously treated for type 2 diabetes. Obes Surg 2010; 20:126-129.
27. Marsk R, Jonas E, Rasmussen F, Naslund E. Nationwide cohort study of postgastric bypass hypoglycaemia including 5,040 patients undergoing surgery for obesity in 1986-2006 in Sweden. Diabetologia 2010; 53: 2307-2311.
28. Patti ME, Goldfine AB. Hypoglycaemia following gastric bypass surgery: diabetes remission in the extreme? Diabetologia 2010; 53:2276-2279.
29. Kaiser AM. Hyperinsulinemic hypoglycemia with nesidioblastosis after gas-tric-bypass surgery. N Engl J Med 2005; 353:2192-2194; author reply 2192-2194. (Pubitemid 41653115)
30. Zagury L, Moreira RO, Guedes EP. Insulinoma misdiagnosed as dumping syndrome after bariatric surgery. Obes Surg 2004; 14:120-123. (Pubitemid 38130728)
31. Meier JJ, Butler AE, Galasso R, Butler PC Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover. Diabetes Care 2006; 29:1554-1559. (Pubitemid 44127580)
32. Rumilla KM, Erickson LA, Service FJ, et al. Hyperinsulinemic hypoglycemia with nesidioblastosis: histologic features and growth factor expression. Mod Pathol 2009; 22:239-245.
33. Brubaker PL, Drucker DJ. Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 2004; 145:2653-2659. (Pubitemid 38686211)
34. Campioni M, Toffolo G, Shuster LT, et al. Incretin effect potentiates beta-cell responsivity to glucose as well as to its rate of change: OGTT and matched intravenous study. Am J Physiol Endocrinol Metab 2007; 292:E54-E60. (Pubitemid 46052925)
35. Rubino F, Schauer PR, Kaplan LM, Cummings DE. Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action. Annu Rev Med 2010; 61:393-411.
36. Thaler JP, Cummings DE. Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery. Endocrinology 2009; 150:2518-2525.
37. McLaughlin T, Peck M, Holst J, Deacon C Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery. J Clin Endocrinol Metab 2010; 95:1851-1855.