Japanese encephalitis virus: From genome to infectome

Microbes and Infection

Volumn 13, Issue 4, 2011, Pages 312-321

  Unni, Salini Krishnan ^a   Růžek, Daniel ^b   Chhatbar, Chintan ^a   Mishra, Ritu ^a   Johri, Manish K ^a   Singh, Sunit K ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b INSTITUTE OF PARASITOLOGY   (Czech Republic)

Author keywords

Arboviral infections; Japanese encephalitis; Mosquito borne infections; Neuropathogenesis; Neurotropic infection

Indexed keywords

CHIMERIVAX JE; CYCLOOXYGENASE 2; CYTOKINE; DNA VACCINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; JAPANESE ENCEPHALITIS VACCINE; LIVE VACCINE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN TYROSINE KINASE INHIBITOR; RANTES; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ANOREXIA; BACKACHE; BRAIN EDEMA; CELLULAR IMMUNITY; CHOREOATHETOSIS; COG WHEEL PHENOMENON; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DRUG SAFETY; EPIDERMOLYSIS; FEVER; GENOTYPE; HEADACHE; HISTOPATHOLOGY; HOST RESISTANCE; HUMAN; HUMORAL IMMUNITY; IMMUNOGENICITY; JAPANESE ENCEPHALITIS; JAPANESE ENCEPHALITIS VIRUS; LIFE CYCLE; MOLECULAR PHYLOGENY; MUSCLE RIGIDITY; MYALGIA; NAUSEA; NERVE INJURY; NEUROTOXICITY; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; SHORT SURVEY; TH1 CELL; VIRUS GENOME; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS STRAIN; VIRUS SURVIVAL; WILD TYPE; ZOONOSIS;

ANIMALS; ENCEPHALITIS VIRUS, JAPANESE; ENCEPHALITIS, JAPANESE; GENOME, VIRAL; HUMANS; IMMUNITY; VIRUS REPLICATION;

ARBOVIRUS; ARDEIDAE; AVES; FLAVIVIRIDAE; JAPANESE ENCEPHALITIS VIRUS; SUIDAE;

EID: 79952442021     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2011.01.002     Document Type: Short Survey

References (91)

1. van den Hurk A.F., Ritchie S.A., Mackenzie J.S. Ecology and geographical expansion of Japanese encephalitis virus. Annu. Rev. Entomol. 2009, 54:17-35.
2. Karunaratne S.H., Hemingway J. Insecticide resistance spectra and resistance mechanisms in populations of Japanese encephalitis vector mosquitoes, Culex tritaeniorhynchus and Cx. gelidus, in Sri Lanka. Med. Vet. Entomol. 2000, 14:430-436.
3. Thenmozhi V., Rajendran R., Ayanar K., Manavalan R., Tyagi B.K. Long-term study of Japanese encephalitis virus infection in Anopheles subpictus in Cuddalore district, Tamil Nadu, South India. Trop. Med. Int. Health 2006, 11:288-293.
4. Solomon T., Dung N.M., Kneen R., Gainsborough M., Vaughn D.W., Khanh V.T. Japanese encephalitis. J. Neurol. Neurosurg. Psychiatry 2000, 68:405-415.
5. Solomon T., Ni H., Beasley D.W., Ekkelenkamp M., Cardosa M.J., Barrett A.D. Origin and evolution of Japanese encephalitis virus in southeast Asia. J. Virol. 2003, 77:3091-3098.
6. Nitatpattana N., Dubot-Peres A., Gouilh M.A., Souris M., Barbazan P., Yoksan S., de Lamballerie X., Gonzalez J.P. Change in Japanese encephalitis virus distribution, Thailand. Emerg. Infect. Dis. 2008, 14:1762-1765.
7. Uchil P.D., Satchidanandam V. Phylogenetic analysis of Japanese encephalitis virus: envelope gene based analysis reveals a fifth genotype, geographic clustering, and multiple introductions of the virus into the Indian subcontinent. Am. J. Trop. Med. Hyg. 2001, 65:242-251.
8. Hasegawa H., Yoshida M., Kobayashi Y., Fujita S. Antigenic analysis of Japanese encephalitis viruses in Asia by using monoclonal antibodies. Vaccine 1995, 13:1713-1721.
9. Saito M., Taira K., Itokazu K., Mori N. Recent change of the antigenicity and genotype of Japanese encephalitis viruses distributed on Okinawa Island, Japan. Am. J. Trop. Med. Hyg. 2007, 77:737-746.
10. Mukhopadhyay S., Kuhn R.J., Rossmann M.G. A structural perspective of the flavivirus life cycle. Nat. Rev. Microbiol. 2005, 3:13-22.
11. Ding D., Kilgore P.E., Clemens J.D., Wei L., Zhi-Yi X. Cost-effectiveness of routine immunization to control Japanese encephalitis in Shanghai, China. Bull. World Health Organ 2003, 81:334-342.
12. Liao C.L., Lin Y.L., Shen S.C., Shen J.Y., Su H.L., Huang Y.L., Ma S.H., Sun Y.C., Chen K.P., Chen L.K. Antiapoptotic but not antiviral function of human bcl-2 assists establishment of Japanese encephalitis virus persistence in cultured cells. J. Virol. 1998, 72:9844-9854.
13. Mason P.W. Maturation of Japanese encephalitis virus glycoproteins produced by infected mammalian and mosquito cells. Virology 1989, 169:354-364.
14. Leung J.Y., Pijlman G.P., Kondratieva N., Hyde J., Mackenzie J.M., Khromykh A.A. Role of nonstructural protein NS2A in flavivirus assembly. J. Virol. 2008, 82:4731-4741.
15. Shiryaev S.A., Ratnikov B.I., Aleshin A.E., Kozlov I.A., Nelson N.A., Lebl M., Smith J.W., Liddington R.C., Strongin A.Y. Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis. J. Virol. 2007, 81:4501-4509.
16. Bera A.K., Kuhn R.J., Smith J.L. Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease. J. Biol. Chem. 2007, 282:12883-12892.
17. Utama A., Shimizu H., Morikawa S., Hasebe F., Morita K., Igarashi A., Hatsu M., Takamizawa K., Miyamura T. Identification and characterization of the RNA helicase activity of Japanese encephalitis virus NS3 protein. FEBS Lett. 2000, 465:74-78.
18. Luo D., Xu T., Watson R.P., Scherer-Becker D., Sampath A., Jahnke W., Yeong S.S., Wang C.H., Lim S.P., Strongin A., Vasudevan S.G., Lescar J. Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. EMBO J. 2008, 27:3209-3219.
19. Lin C.W., Cheng C.W., Yang T.C., Li S.W., Cheng M.H., Wan L., Lin Y.J., Lai C.H., Lin W.Y., Kao M.C. Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42. Virus Res. 2008, 137:49-55.
20. Lin R.J., Chang B.L., Yu H.P., Liao C.L., Lin Y.L. Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism. J. Virol. 2006, 80:5908-5918.
21. Nawa M., Takasaki T., Yamada K., Kurane I., Akatsuka T. Interference in Japanese encephalitis virus infection of Vero cells by a cationic amphiphilic drug, chlorpromazine. J. Gen. Virol. 2003, 84:1737-1741.
22. Lee C.J., Lin H.R., Liao C.L., Lin Y.L. Cholesterol effectively blocks entry of flavivirus. J. Virol. 2008, 82:6470-6480.
23. Chien Y.J., Chen W.J., Hsu W.L., Chiou S.S. Bovine lactoferrin inhibits Japanese encephalitis virus by binding to heparan sulfate and receptor for low density lipoprotein. Virology 2008, 379:143-151.
24. Ren J., Ding T., Zhang W., Song J., Ma W. Does Japanese encephalitis virus share the same cellular receptor with other mosquito-borne flaviviruses on the C6/36 mosquito cells?. Virol. J. 2007, 4:83.
25. Chen C.J., Kuo M.D., Chien L.J., Hsu S.L., Wang Y.M., Lin J.H. RNA-protein interactions: involvement of NS3, NS5, and 3' noncoding regions of Japanese encephalitis virus genomic RNA. J. Virol. 1997, 71:3466-3473.
26. Hahn C.S., Hahn Y.S., Rice C.M., Lee E., Dalgarno L., Strauss E.G., Strauss J.H. Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequences. J. Mol. Biol. 1987, 198:33-41.
27. Uchil P.D., Satchidanandam V. Characterization of RNA synthesis, replication mechanism, and in vitro RNA-dependent RNA polymerase activity of Japanese encephalitis virus. Virology 2003, 307:358-371.
28. Uchil P.D., Kumar A.V., Satchidanandam V. Nuclear localization of flavivirus RNA synthesis in infected cells. J. Virol. 2006, 80:5451-5464.
29. Kumar P., Uchil P.D., Sulochana P., Nirmala G., Chandrashekar R., Haridattatreya M., Satchidanandam V. Screening for T cell-eliciting proteins of Japanese encephalitis virus in a healthy JE-endemic human cohort using recombinant baculovirus-infected insect cell preparations. Arch. Virol. 2003, 148:1569-1591.
30. Yun S.I., Choi Y.J., Song B.H., Lee Y.M. 3' cis-acting elements that contribute to the competence and efficiency of Japanese encephalitis virus genome replication: functional importance of sequence duplications, deletions, and substitutions. J. Virol. 2009, 83:7909-7930.
31. Sapkal G.N., Wairagkar N.S., Ayachit V.M., Bondre V.P., Gore M.M. Detection and isolation of Japanese encephalitis virus from blood clots collected during the acute phase of infection. Am. J. Trop. Med. Hyg. 2007, 77:1139-1145.
32. Aleyas A.G., George J.A., Han Y.W., Rahman M.M., Kim S.J., Han S.B., Kim B.S., Kim K., Eo S.K. Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways. J. Immunol. 2009, 183:2462-2474.
33. Aleyas A.G., Han Y.W., George J.A., Kim B., Kim K., Lee C.K., Eo S.K. Multifront assault on antigen presentation by Japanese encephalitis virus subverts CD8+ T cell responses. J. Immunol. 2010, 185:1429-1441.
34. Johnson R.T., Burke D.S., Elwell M., Leake C.J., Nisalak A., Hoke C.H., Lorsomrudee W. Japanese encephalitis: immunocytochemical studies of viral antigen and inflammatory cells in fatal cases. Ann. Neurol. 1985, 18:567-573.
35. Liou M.L., Hsu C.Y. Japanese encephalitis virus is transported across the cerebral blood vessels by endocytosis in mouse brain. Cell Tissue Res. 1998, 293:389-394.
36. Yasui K. Neuropathogenesis of Japanese encephalitis virus. J. Neurovirol. 2002, 8(Suppl. 2):112-114.
37. Su H.L., Liao C.L., Lin Y.L. Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response. J. Virol. 2002, 76:4162-4171.
38. Lin R.J., Liao C.L., Lin Y.L. Replication-incompetent virions of Japanese encephalitis virus trigger neuronal cell death by oxidative stress in a culture system. J. Gen. Virol. 2004, 85:521-533.
39. Hase T. Virus-neuron interactions in the mouse brain infected with Japanese encephalitis virus. Virchows Arch. B. Cell Pathol. Incl Mol. Pathol. 1993, 64:161-170.
40. Yang K.D., Yeh W.T., Chen R.F., Chuon H.L., Tsai H.P., Yao C.W., Shaio M.F. A model to study neurotropism and persistency of Japanese encephalitis virus infection in human neuroblastoma cells and leukocytes. J. Gen. Virol. 2004, 85:635-642.
41. Ogata A., Nagashima K., Hall W.W., Ichikawa M., Kimura-Kuroda J., Yasui K. Japanese encephalitis virus neurotropism is dependent on the degree of neuronal maturity. J. Virol. 1991, 65:880-886.
42. Kimura-Kuroda J., Ichikawa M., Ogata A., Nagashima K., Yasui K. Specific tropism of Japanese encephalitis virus for developing neurons in primary rat brain culture. Arch. Virol. 1993, 130:477-484.
43. Levine B., Huang Q., Isaacs J.T., Reed J.C., Griffin D.E., Hardwick J.M. Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature 1993, 361:739-742.
44. Griffin D.E. Arboviruses and the central nervous system. Springer Semin. Immunopathol. 1995, 17:121-132.
45. Ubol S., Tucker P.C., Griffin D.E., Hardwick J.M. Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein. Proc. Natl. Acad. Sci. U S A 1994, 91:5202-5206.
46. Das S., Basu A. Japanese encephalitis virus infects neural progenitor cells and decreases their proliferation. J. Neurochem. 2008, 106:1624-1636.
47. Thongtan T., Cheepsunthorn P., Chaiworakul V., Rattanarungsan C., Wikan N., Smith D.R. Highly permissive infection of microglial cells by Japanese encephalitis virus: a possible role as a viral reservoir. Microbes Infect. 2010, 12:37-45.
48. German A.C., Myint K.S., Mai N.T., Pomeroy I., Phu N.H., Tzartos J., Winter P., Collett J., Farrar J., Barrett A., Kipar A., Esiri M.M., Solomon T. A preliminary neuropathological study of Japanese encephalitis in humans and a mouse model. Trans. R Soc. Trop. Med. Hyg. 2006, 100:1135-1145.
49. Ghoshal A., Das S., Ghosh S., Mishra M.K., Sharma V., Koli P., Sen E., Basu A. Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia 2007, 55:483-496.
50. Sharma S., Mathur A., Prakash V., Kulshreshtha R., Kumar R., Chaturvedi U.C. Japanese encephalitis virus latency in peripheral blood lymphocytes and recurrence of infection in children. Clin. Exp. Immunol. 1991, 85:85-89.
51. Ravi V., Desai A.S., Shenoy P.K., Satishchandra P., Chandramuki A., Gourie-Devi M. Persistence of Japanese encephalitis virus in the human nervous system. J. Med. Virol. 1993, 40:326-329.
52. Fischer M., Lindsey N., Staples J.E., Hills S. Japanese encephalitis vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep. 2010, 59:1-27.
53. Tiroumourougane S.V., Raghava P., Srinivasan S. Japanese viral encephalitis. Postgrad. Med. J. 2002, 78:205-215.
54. Li Z.S., Hong S.F., Gong N.L. Immunohistochemical study on Japanese B encephalitis. Chin. Med. J. (Engl) 1988, 101:768-771.
55. Ishii T., Matsushita M., Hamada S. Characteristic residual neuropathological features of Japanese B encephalitis. Acta Neuropathol. 1977, 38:181-186.
56. Kalita J., Misra U.K. The substantia nigra is also involved in Japanese encephalitis. AJNR Am. J. Neuroradiol. 2000, 21:1978-1980.
57. Miyake M. The pathology of Japanese encephalitis. A review. Bull. World Health Organ 1964, 30:153-160.
58. Solomon T., Thao T.T., Lewthwaite P., Ooi M.H., Kneen R., Dung N.M., White N. A cohort study to assess the new WHO Japanese encephalitis surveillance standards. Bull. World Health Organ 2008, 86:178-186.
59. Burke D.S., Nisalak A., Ussery M.A., Laorakpongse T., Chantavibul S. Kinetics of IgM and IgG responses to Japanese encephalitis virus in human serum and cerebrospinal fluid. J. Infect. Dis. 1985, 151:1093-1099.
60. Innis B.L., Nisalak A., Nimmannitya S., Kusalerdchariya S., Chongswasdi V., Suntayakorn S., Puttisri P., Hoke C.H. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am. J. Trop. Med. Hyg. 1989, 40:418-427.
61. Krishna V.D., Rangappa M., Satchidanandam V. Virus-specific cytolytic antibodies to nonstructural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells. J. Virol. 2009, 83:4766-4777.
62. Kimura-Kuroda J., Yasui K. Protection of mice against Japanese encephalitis virus by passive administration with monoclonal antibodies. J. Immunol. 1988, 141:3606-3610.
63. Zhang M.J., Wang M.J., Jiang S.Z., Ma W.Y. Passive protection of mice, goats, and monkeys against Japanese encephalitis with monoclonal antibodies. J. Med. Virol. 1989, 29:133-138.
64. Verma S.K., Gupta N., Pattnaik P., Babu J.P., Rao P.V., Kumar S. Antibodies against refolded recombinant envelope protein (domain III) of Japanese encephalitis virus inhibit the JEV infection to Porcine Stable Kidney cells. Protein Pept. Lett. 2009, 16:1334-1341.
65. Feng G.H., Liu N., Zhou Y., Zhai Y.Z., Li X.M., Dou X.G. Immunologic analysis induced by DNA vaccine encoding E protein of Beijing-1 strain derived from Japanese encephalitis virus. Intervirology 2007, 50:93-98.
66. Xu X.G., Wang Z.S., Zhang Q., Li Z.C., Zhao H.N., Li W., Tong D.W., Liu H.J. Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. Vaccine 2010.
67. Joly E., Mucke L., Oldstone M.B. Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science 1991, 253:1283-1285.
68. Daar A.S., Fuggle S.V., Fabre J.W., Ting A., Morris P.J. The detailed distribution of MHC Class II antigens in normal human organs. Transplantation 1984, 38:293-298.
69. Daar A.S., Fuggle S.V., Fabre J.W., Ting A., Morris P.J. The detailed distribution of HLA-A, B, C antigens in normal human organs. Transplantation 1984, 38:287-292.
70. Abraham S., Nagaraj A.S., Basak S., Manjunath R. Japanese encephalitis virus utilizes the canonical pathway to activate NF-kappaB but it utilizes the type I interferon pathway to induce major histocompatibility complex class I expression in mouse embryonic fibroblasts. J. Virol. 2010, 84:5485-5493.
71. Fujii Y., Kitaura K., Nakamichi K., Takasaki T., Suzuki R., Kurane I. Accumulation of T-cells with selected T-cell receptors in the brains of Japanese encephalitis virus-infected mice. Jpn. J. Infect. Dis. 2008, 61:40-48.
72. Verma S.K., Kumar S., Gupta N., Vedi S., Bhattacharya S.M., Lakshmana Rao P.V. Bacterially expressed recombinant envelope protein domain III of Japanese encephalitis virus (rJEV-DIII) elicits Th1 type of immune response in BALB/c mice. Vaccine 2009, 27:6905-6909.
73. Biswas S.M., Ayachit V.M., Sapkal G.N., Mahamuni S.A., Gore M.M. Japanese encephalitis virus produces a CD4+ Th2 response and associated immunoprotection in an adoptive-transfer murine model. J. Gen. Virol. 2009, 90:818-826.
74. Ravi V., Parida S., Desai A., Chandramuki A., Gourie-Devi M., Grau G.E. Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients. J. Med. Virol. 1997, 51:132-136.
75. Swarup V., Das S., Ghosh S., Basu A. Tumor necrosis factor receptor-1-induced neuronal death by TRADD contributes to the pathogenesis of Japanese encephalitis. J. Neurochem. 2007, 103:771-783.
76. Das S., Ghosh D., Basu A. Japanese encephalitis virus induce immuno-competency in neural stem/progenitor cells. PLoS One 2009, 4:e8134.
77. Kumar P., Sulochana P., Nirmala G., Chandrashekar R., Haridattatreya M., Satchidanandam V. Impaired T helper 1 function of nonstructural protein 3-specific T cells in Japanese patients with encephalitis with neurological sequelae. J. Infect. Dis. 2004, 189:880-891.
78. Swarup V., Ghosh J., Duseja R., Ghosh S., Basu A. Japanese encephalitis virus infection decrease endogenous IL-10 production: correlation with microglial activation and neuronal death. Neurosci. Lett. 2007, 420:144-149.
79. Raung S.L., Chen S.Y., Liao S.L., Chen J.H., Chen C.J. Tyrosine kinase inhibitors attenuate Japanese encephalitis virus-induced neurotoxicity. Biochem. Biophys. Res. Commun. 2005, 327:399-406.
80. Chen C.J., Chen J.H., Chen S.Y., Liao S.L., Raung S.L. Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection. J. Virol. 2004, 78:12107-12119.
81. Singh A., Kulshreshtha R., Mathur A. Secretion of the chemokine interleukin-8 during Japanese encephalitis virus infection. J. Med. Microbiol. 2000, 49:607-612.
82. Bhowmick S., Duseja R., Das S., Appaiahgiri M.B., Vrati S., Basu A. Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitis. Neurosci. Lett. 2007, 414:45-50.
83. Paulke-Korinek M., Kollaritsch H. Japanese encephalitis and vaccines: past and future prospects. Wien Klin Wochenschr 2008, 120:15-19.
84. Tauber E., Kollaritsch H., Korinek M., Rendi-Wagner P., Jilma B., Firbas C., Schranz S., Jong E., Klingler A., Dewasthaly S., Klade C.S. Safety and immunogenicity of a Vero-cell-derived, inactivated Japanese encephalitis vaccine: a non-inferiority, phase III, randomised controlled trial. Lancet 2007, 370:1847-1853.
85. Srivastava A.K., Putnak J.R., Lee S.H., Hong S.P., Moon S.B., Barvir D.A., Zhao B., Olson R.A., Kim S.O., Yoo W.D., Towle A.C., Vaughn D.W., Innis B.L., Eckels K.H. A purified inactivated Japanese encephalitis virus vaccine made in Vero cells. Vaccine 2001, 19:4557-4565.
86. Ashok M.S., Rangarajan P.N. Evaluation of the potency of BIKEN inactivated Japanese encephalitis vaccine and DNA vaccines in an intracerebral Japanese encephalitis virus challenge. Vaccine 2000, 19:155-157.
87. Kuzuhara S., Nakamura H., Hayashida K., Obata J., Abe M., Sonoda K., Nishiyama K., Sugawara K., Takeda K., Honda T., Matsui H., Shigaki T., Kino Y., Mizokami H., Tanaka M., Mizuno K., Ueda K. Non-clinical and phase I clinical trials of a Vero cell-derived inactivated Japanese encephalitis vaccine. Vaccine 2003, 21:4519-4526.
88. Jelinek T. Ixiaro: a new vaccine against Japanese encephalitis. Expert Rev. Vaccines 2009, 8:1501-1511.
89. Beasley D.W., Li L., Suderman M.T., Guirakhoo F., Trent D.W., Monath T.P., Shope R.E., Barrett A.D. Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax-JE experimental vaccine. Vaccine 2004, 22:3722-3726.
90. Lin Y.L., Chen L.K., Liao C.L., Yeh C.T., Ma S.H., Chen J.L., Huang Y.L., Chen S.S., Chiang H.Y. DNA immunization with Japanese encephalitis virus nonstructural protein NS1 elicits protective immunity in mice. J. Virol. 1998, 72:191-200.
91. Harakuni T., Kohama H., Tadano M., Uechi G., Tsuji N., Matsumoto Y., Miyata T., Tsuboi T., Oku H., Arakawa T. Mucosal vaccination approach against mosquito-borne Japanese encephalitis virus. Jpn. J. Infect. Dis. 2009, 62:37-45.