Hyperphosphorylated neurofilament NF-H as a biomarker of the efficacy of minocycline therapy for spinal cord injury

Spinal Cord

Volumn 49, Issue 3, 2011, Pages 333-336

  Ueno, T ^a,b   Ohori, Y ^a,b   Ito, J ^a,b   Hoshikawa, S ^a   Yamamoto, S ^a   Nakamura, K ^b   Tanaka, S ^b   Akai, M ^a   Tobimatsu, Y ^a   Ogata, T ^a  

^a NATIONAL REHABILITATION CENTER FOR PERSONS WITH DISABILITIES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

biomarker; minocycline; pNF H; spinal cord injury

Indexed keywords

MINOCYCLINE; NEUROFILAMENT PROTEIN; NEUROFILAMENT PROTEIN H; PHOSPHOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONTUSION; CONVALESCENCE; DRUG EFFICACY; LOCOMOTION; MOLECULAR WEIGHT; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; RAT; SCORING SYSTEM; SPINAL CORD INJURY; TREATMENT OUTCOME;

ANIMALS; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; MINOCYCLINE; NEUROFILAMENT PROTEINS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD INJURIES;

EID: 79952441779     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2010.116     Document Type: Article

References (16)

1. McDonald JW, Sadowsky C Spinal-cord injury. Lancet 2002; 359: 417-425. (Pubitemid 34158956)
2. Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 1997; 3: 73-76. (Pubitemid 27019144)
3. Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD et al. Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury J Neurosci 2004; 24: 2182-2190. (Pubitemid 38314550)
4. Fawcett JW, Curt A, Steeves JD, Coleman WP, Tuszynski MH, Lammertse D et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 2007; 45: 190-205. (Pubitemid 46340848)
5. Honda M, Tsuruta R, Kaneko T, Kasaoka S, Yagi T, Todani M et al. Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase. J Trauma 2010; 69: 104-109.
6. Berger RP, Beers SR, Richichi R, Wiesman D, Adelson PD. Serum biomarker concentrations and outcome after pediatric traumatic brain injury J Neurotrauma 2007; 24: 1793-1801.
7. Marquardt G, Setzer M, Szelenyi A, Seifert V, Gerlach R. Significance of serial S100b and NSE serum measurements in surgically treated patients with spondylotic cervical myelopathy Acta Neurochir (Wien) 2009; 151: 1439-1443.
8. Pouw MH, Hosman AJ, van Middendorp JJ, Verbeek MM, Vos PE, van de Meent H. Biomarkers in spinal cord injury Spinal Cord 2009; 47: 519-525.
9. Shaw G, Yang C, Ellis R, Anderson K, Parker Mickle J, Scheff Setal. Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury Biochem Biophys Res Commun 2005; 336: 1268-1277. (Pubitemid 41383458)
10. Lewis SB, Wolper RA, Miralia L, Yang C, Shaw G. Detection of phosphorylated NF-H in the cerebrospinal fluid and blood of aneurysmal subarachnoid hemorrhage patients. J Cereb Blood Flow Metab 2008; 28: 1261-1271. (Pubitemid 351733343)
11. Loy DN, Sroufe AE, Pelt JL, Burke DA, Cao QL, Talbott JF et al. Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100beta. Neurosurgery 2005; 56: 391-397; discussion 391-397.
12. Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC et al. Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury J Neurosci 2007; 27: 7751-7761. (Pubitemid 47093808)
13. Pinzon A, Marcillo A, Quintana A, Stamler S, Bunge MB, Bramlett HM et al. A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model. Brain Res 2008; 1243: 146-151.
14. Lee SM, Yune TY, Kim SJ, Park DW, Lee YK, Kim YC et al. Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat J Neurotrauma 2003; 20: 1017-1027. (Pubitemid 37288561)
15. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995; 12: 1-21.
16. Boylan K, Yang C, Crook J, Overstreet K, Heckman M, Wang Y et al. Immunoreactivity of the phosphorylated axonal neurofila-ment H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarker. J Neurochem 2009; 111: 1182-1191.