Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells

Acta Pharmacologica Sinica

Volumn 32, Issue 3, 2011, Pages 361-367

  Zhang, Li ^a   Zhang, Yi ^a   Liu, Xiao Yuan ^a   Qin, Zheng Hong ^a   Yang, Jin Ming ^b  

^a SOOCHOW UNIVERSITY   (China)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

anoikis; eEF 2 kinase; glioma; invasion; migration

Indexed keywords

BIM PROTEIN; CASPASE 3; ELONGATION FACTOR 2 KINASE; PROPIDIUM IODIDE; SMALL INTERFERING RNA;

ANOIKIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CELL VIABILITY; CHEMOSENSITIZATION; CONTROLLED STUDY; DISEASE MARKER; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GLIOBLASTOMA; GLIOMA CELL; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PHENOTYPE; PROGNOSIS; PROTEIN CLEAVAGE; WESTERN BLOTTING;

ANOIKIS; CELL LINE, TUMOR; ELONGATION FACTOR 2 KINASE; GLIOBLASTOMA; GLIOMA; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASM INVASIVENESS; RNA INTERFERENCE;

EID: 79952377033     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.213     Document Type: Article

References (28)

1. Serfass L, Van Herpen C, Saghatchian M. Molecular targets and cancer therapeutics. Eur J Cancer 2007; 43: 1494-5
2. Wu H, Yang JM, Jin S, Zhang H, Hait WN. Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res 2006; 66: 3015-23
3. Ryazanov AG, Rudkin BB, Spirin AS. Regulation of protein synthesis at the elongation stage. New insights into the control of gene expression eukaryotes. FEBS Lett 1991; 285: 170-5
4. Hait WN, Wu H, Jin S, Yang JM. Elongation factor-2 kinase: its role in protein synthesis and autophagy Autophagy 2006; 2: 294-6 (Pubitemid 44342372)
5. Celis JE, Madsen P, Ryazanov AG. Increased phosphorylation of elongation factor 2 during mitosis in transformed human amnion cells correlates with a decreased rate of protein synthesis. Proc Natl Acad Sci USA 1990; 87: 4231-5
6. Donze O, Jagus R, Koromilas AE, Hershey Jw, Sonenberg N. Abroga-tion of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. Embo J 1995; 14: 3828-34
7. Herschman HR. Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem 1991; 60: 281-319.
8. Xu CS, Chang CF. Expression profles of the genes associated with metabolism and transport of amino acids and their derivatives in rat iver regeneration. Amino Acids 2008; 34: 91-102.
9. Nunes PH, Calaza Kda C, Albuquerque LM, Fragel-Madeira L, Sholl-Franco A, Ventura AL. Signal transduction pathways associated with ATP-induced proliferation of cell progenitors in the intact embryonic retina. Int J Dev Neurosci 2007; 25: 499-508 (Pubitemid 350184241)
10. Edwards DR, Mahadevan LC. Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors. Embo J 1992; 11: 2415-24
11. Clark DE, Errington TM, Smith JA, Frierson HF Jr, Weber MJ, Lannigan DA. The serine/threonine protein kinase, p90 ribosomal S6 kinase is an important regulator of prostate cancer cell proliferation. Cancer Res 2005; 65: 3108-16. (Pubitemid 40524591)
12. Zinck R, Cahill MA, Kracht M, Sachsenmaier C, Hipskind RA, Nordheim A. Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1. Mol Cell Biol 1995; 15: 4930-8
13. Cano E, Hazzalin CA, Mahadevan LC. Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and-2 are implicated in the induction of c-fos and c-jun. Mol Cel Biol 1994; 14: 7352-62
14. white-Gilbertson S, Kurtz DT, Voelkel-Johnson C. The role of protein synthesis in cell cycling and cancer. Mol Oncol 2009; 3: 402-8
15. Kaczmarek L, Surmacz E, Baserga R. Cycloheximide or puromycin can substitute for PDGF in inducing cellular DNA synthesis in quiescent 3T3 cells. Cell Biol Int Rep 1986; 10: 455-63 (Pubitemid 16091800)
16. Connolly E, Braunstein S, Formenti S, Schneider RJ. Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells Mol Cell Biol 2006; 26: 3955-65 (Pubitemid 43726410)
17. Arora S, Yang JM, Hait WN. Identifcation of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinase. Cancer Res 2005; 65: 3806-10 (Pubitemid 40616359)
18. Bagaglio DM, Cheng EH, Gorelick FS, Mitsui K, Nairn AC, Hait wN Phosphorylation of elongation factor 2 in normal and malignant rat glial cells. Cancer Res 1993; 53: 2260-4 (Pubitemid 23156810)
19. Parmer TG, ward MD, Yurkow EJ, Vyas VH, Kearney TJ, Hait wN Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer Br J Cancer 1999; 79: 59-64 (Pubitemid 28566927)
20. Salhia B, Tran NL, Symons M, winkles JA, Rutka JT, Berens ME Molecular pathways triggering glioma cell invasion. Expert Rev Mo Diagn 2006; 6: 613-26 (Pubitemid 44179946)
21. Giese A, Bjerkvig R, Berens ME, westphal M. Cost of migration nvasion of malignant gliomas and implications for treatment. J Clin Oncol 2003; 21: 1624-36 (Pubitemid 46594118)
22. Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, et al. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 2003; 5: 733-40 (Pubitemid 36986781)
23. Wu H, Yang JM, Jin S, Zhang H, Hait WN. Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res 2006; 66: 3015-23
24. Reddy KB, Nabha SM, Atanaskova N. Role of MAP kinase in tumor progression and invasion. Cancer Metastasis Rev 2003; 22: 395-403 (Pubitemid 36791895)
25. Yoeli-Lerner M, Toker A. Akt/PKB signaling in cancer: a function in cel motility and invasion. Cell Cycle 2006; 5: 603-5
26. Chen Y, Matsushita M, Nairn AC, Damuni Z, Cai D, Frerichs KU, et al. Mechanisms for increased levels of phosphorylation of elongation factor-2 during hibernation in ground squirrels. Biochemistry 2001; 40: 11565-70 (Pubitemid 32911300)
27. Collins NL, Reginato MJ, Paulus JK, Sgroi DC, Labaer J, Brugge JS. G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression. Mol Cell Biol 2005; 25: 5282-91 (Pubitemid 40781124)
28. Tan TT, Degenhardt K, Nelson DA, Beaudoin B, Nieves-Neira w Bouillet P, et al. Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy Cancer Cell 2005; 7: 227-38 (Pubitemid 40568682)