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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1731-1735

Discovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes

(7) Shan, Zhenwei a Peng, Min b Fan, Houxing c Lu, Qingtao a Lu, Peng c Zhao, Chuansheng c Chen, Yilang c

a SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE (China)

b HUNAN UNIVERSITY OF CHINESE MEDICINE (China)

c Shanghai Sun Sail Pharmaceutical Science and Technology Co Ltd (China)

Author keywords

Dipeptidyl peptidase IV inhibitors; Triazolopiperidine; Type 2 diabetes

Indexed keywords

[1,2,3]TRIAZOLOPIPERIDINE DERIVATIVE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HALF LIFE TIME; IC 50; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PHARMACODYNAMICS; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMIDES; ANIMALS; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG DISCOVERY; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED ICR; PIPERIDINES;

MUS;

EID: 79952364204 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2011.01.086 Document Type: Article

Times cited : (34)

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