Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl] cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1880-1886

  Chen, Ping ^a   Caldwell, Charles G ^a   Ashton, Wallace ^a   Wu, Joseph K ^a   He, Huaibing ^a   Lyons, Kathryn A ^a   Thornberry, Nancy A ^a   Weber, Ann E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 AMINOCARBONYLPYRIDYL PIPERIDINE); 4 (1,2,3 THIADIAZOLYL)BENZENSULFONAMIDE DERIVATIVE; 4 [1 AMINO 2 [2,5 DIFLUOROPHENYL]ETHYL]PIPERIDINE; 4 AMINO CYCLOHEXANE; [1 AMINO 2 [2,5 DIFLUOROPHENYL]ETHYL]CYCLOHEXANE; AMIDE; CYCLOHEXANE DERIVATIVE; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; N METHYL (2,5 DIMETHYLISOXAZOL YL)SULFONAMIDE; PIPERIDINE DERIVATIVE; PROTEINASE; SITAGLIPTIN; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN;

ANIMALS; BIOLOGICAL AVAILABILITY; CYCLOHEXANES; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; HALF-LIFE; PIPERIDINES; RATS;

RATTUS;

EID: 79952363348     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.060     Document Type: Article

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